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Methods based on partial least squares (PLS) regression, which has recently gained much attention in the analysis of high-dimensional genomic datasets, have been developed since the early 2000s for performing variable selection. Most of…

Methodology · Statistics 2021-08-31 Jérémy Magnanensi , Myriam Maumy-Bertrand , Nicolas Meyer , Frédéric Bertrand

This paper introduces a high-dimensional binary variate model that accommodates nonstationary covariates and factors, and studies their asymptotic theory. This framework encompasses scenarios where single indices are nonstationary or…

Statistics Theory · Mathematics 2025-05-29 Xinbing Kong , Bin Wu , Wuyi Ye

This work studies the properties of the maximum likelihood estimator (MLE) of a non-linear model with Gaussian errors and multidimensional parameter. The observations are collected in a two-stage experimental design and are dependent since…

Statistics Theory · Mathematics 2019-11-01 Nancy Flournoy , Caterina May , Chiara Tommasi

Background: Advanced methods for causal inference, such as targeted maximum likelihood estimation (TMLE), require certain conditions for statistical inference. However, in situations where there is not differentiability due to data sparsity…

Expected shortfall is defined as the average over the tail below (or above) a certain quantile of a probability distribution. Expected shortfall regression provides powerful tools for learning the relationship between a response variable…

Methodology · Statistics 2025-01-03 Shushu Zhang , Xuming He , Kean Ming Tan , Wen-Xin Zhou

Confidence intervals based on penalized maximum likelihood estimators such as the LASSO, adaptive LASSO, and hard-thresholding are analyzed. In the known-variance case, the finite-sample coverage properties of such intervals are determined…

Statistics Theory · Mathematics 2010-03-16 Benedikt M. Pötscher , Ulrike Schneider

A central goal of causal inference is to detect and estimate the treatment effects of a given treatment or intervention on an outcome variable of interest, where a member known as the heterogeneous treatment effect (HTE) is of growing…

Statistics Theory · Mathematics 2020-10-27 Zijun Gao , Yanjun Han

Estimating average treatment effects from observational data is challenging under practical violations of the positivity assumption. Targeted Maximum Likelihood Estimators (TMLEs) are widely used because of their double robustness and…

Methodology · Statistics 2026-04-28 Yichen Xu , Susan Gruber , Mark J. van der Laan

Identifying a biomarker or treatment-dose threshold that marks a specified level of risk is an important problem, especially in clinical trials. This risk, viewed as a function of thresholds and possibly adjusted for covariates, we call the…

Methodology · Statistics 2023-03-22 Lars van der Laan , Wenbo Zhang , Peter B. Gilbert

Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different population subgroups. While much of treatment effect heterogeneity analysis focuses on the…

A nonparametric procedure to estimate the conditional probability that a nonstationary geostatistical process exceeds a certain threshold value is proposed. The method consists of a bootstrap algorithm that combines conditional simulation…

Empirical best linear unbiased prediction (EBLUP) method uses a linear mixed model in combining information from different sources of information. This method is particularly useful in small area problems. The variability of an EBLUP is…

Statistics Theory · Mathematics 2008-12-18 Snigdhansu Chatterjee , Partha Lahiri , Huilin Li

We consider the problem of estimating the average treatment effect (ATE) when both randomized control trial (RCT) data and external real-world data (RWD) are available. We decompose the ATE estimand as the difference between a pooled-ATE…

Methodology · Statistics 2025-01-22 Mark van der Laan , Sky Qiu , Jens Magelund Tarp , Lars van der Laan

We propose a novel model selection algorithm based on a penalized maximum likelihood estimator (PMLE) for functional hidden dynamic geostatistical models (f-HDGM). These models employ a classic mixed-effect regression structure with…

Methodology · Statistics 2023-10-24 Paolo Maranzano , Philipp Otto , Alessandro Fassò

The Adaptive Lasso(Alasso) was proposed by Zou [\textit{J. Amer. Statist. Assoc. \textbf{101} (2006) 1418-1429}] as a modification of the Lasso for the purpose of simultaneous variable selection and estimation of the parameters in a linear…

Methodology · Statistics 2018-02-16 Debraj Das , Karl Gregory , S. N. Lahiri

A sparse precision matrix can be directly translated into a sparse Gaussian graphical model under the assumption that the data follow a joint normal distribution. This neat property makes high-dimensional precision matrix estimation very…

Statistics Theory · Mathematics 2013-02-14 Lingzhou Xue , Hui Zou

With regard to a three-step estimation procedure, proposed without theoretical discussion by Li and You in Journal of Applied Statistics and Management, for a nonparametric regression model with time-varying regression function, local…

Statistics Theory · Mathematics 2020-10-27 Jiyanglin Li , Tao Li

We study nonparametric isotonic confidence intervals for monotone functions. In Banerjee and Wellner (2001) pointwise confidence intervals, based on likelihood ratio tests for the restricted and unrestricted MLE in the current status model,…

Statistics Theory · Mathematics 2015-02-17 Piet Groeneboom , Geurt Jongbloed

In this work, a fully nonparametric geostatistical approach to estimate threshold exceeding probabilities is proposed. To estimate the large-scale variability (spatial trend) of the process, the nonparametric local linear regression…

Applying standard statistical methods after model selection may yield inefficient estimators and hypothesis tests that fail to achieve nominal type-I error rates. The main issue is the fact that the post-selection distribution of the data…

Methodology · Statistics 2019-05-23 Amit Meir , Mathias Drton