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To mitigate the potential adverse health effects of simultaneous multi-drug use, including unexpected side effects and interactions, accurately identifying and predicting drug-drug interactions (DDIs) is considered a crucial task in the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Yuqin He , Tengfei Ma , Chaoyi Li , Pengsen Ma , Hongxin Xiang , Jianmin Wang , Yiping Liu , Bosheng Song , Xiangxiang Zeng

Distantly-Supervised Named Entity Recognition (DS-NER) is widely used in real-world scenarios. It can effectively alleviate the burden of annotation by matching entities in existing knowledge bases with snippets in the text but suffer from…

Computation and Language · Computer Science 2025-07-04 Shuzheng Si , Helan Hu , Haozhe Zhao , Shuang Zeng , Kaikai An , Zefan Cai , Baobao Chang

Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the…

Machine Learning · Statistics 2022-12-01 Pietro Bongini , Elisa Messori , Niccolò Pancino , Monica Bianchini

Accurate drug response prediction (DRP) is a crucial yet challenging task in precision medicine. This paper presents a novel Attention-Guided Multi-omics Integration (AGMI) approach for DRP, which first constructs a Multi-edge Graph (MeG)…

Genomics · Quantitative Biology 2022-01-20 Ruiwei Feng , Yufeng Xie , Minshan Lai , Danny Z. Chen , Ji Cao , Jian Wu

Recent advances in deep neural models allow us to build reliable named entity recognition (NER) systems without handcrafting features. However, such methods require large amounts of manually-labeled training data. There have been efforts on…

Computation and Language · Computer Science 2018-09-12 Jingbo Shang , Liyuan Liu , Xiang Ren , Xiaotao Gu , Teng Ren , Jiawei Han

Distantly supervision automatically generates plenty of training samples for relation extraction. However, it also incurs two major problems: noisy labels and imbalanced training data. Previous works focus more on reducing wrongly labeled…

Computation and Language · Computer Science 2021-05-24 Chenhao Xie , Jiaqing Liang , Jingping Liu , Chengsong Huang , Wenhao Huang , Yanghua Xiao

Drug Side-Effects (DSEs) have a high impact on public health, care system costs, and drug discovery processes. Predicting the probability of side-effects, before their occurrence, is fundamental to reduce this impact, in particular on drug…

Quantitative Methods · Quantitative Biology 2022-02-17 Pietro Bongini , Franco Scarselli , Monica Bianchini , Giovanna Maria Dimitri , Niccolò Pancino , Pietro Liò

Mining relationships between treatment(s) and medical problem(s) is vital in the biomedical domain. This helps in various applications, such as decision support system, safety surveillance, and new treatment discovery. We propose a deep…

Machine Learning · Computer Science 2018-07-02 Veera Raghavendra Chikka , Kamalakar Karlapalem

We introduce a framework for dynamic adversarial discovery of information (DADI), motivated by a scenario where information (a feature set) is used by third parties with unknown objectives. We train a reinforcement learning agent to…

Named entity recognition (NER) identifies typed entity mentions in raw text. While the task is well-established, there is no universally used tagset: often, datasets are annotated for use in downstream applications and accordingly only…

Computation and Language · Computer Science 2019-10-08 Xiao Huang , Li Dong , Elizabeth Boschee , Nanyun Peng

In practical scenario, relation extraction needs to first identify entity pairs that have relation and then assign a correct relation class. However, the number of non-relation entity pairs in context (negative instances) usually far…

Computation and Language · Computer Science 2019-06-24 Wei Ye , Bo Li , Rui Xie , Zhonghao Sheng , Long Chen , Shikun Zhang

We present the full-size Russian complexly NER-labeled corpus of Internet user reviews, along with an evaluation of accuracy levels reached on this corpus by a set of advanced deep learning neural networks to extract the pharmacologically…

Distant supervision (DS) is a promising approach for relation extraction but often suffers from the noisy label problem. Traditional DS methods usually represent an entity pair as a bag of sentences and denoise labels using multi-instance…

Computation and Language · Computer Science 2020-12-10 Lingyong Yan , Xianpei Han , Le Sun , Fangchao Liu , Ning Bian

Drug recommendation is an essential task in machine learning-based clinical decision support systems. However, the risk of drug-drug interactions (DDI) between co-prescribed medications remains a significant challenge. Previous studies have…

Machine Learning · Computer Science 2025-10-10 Chongmyung Kwon , Yujin Kim , Seoeun Park , Yunji Lee , Charmgil Hong

In the last decades, people have been consuming and combining more drugs than before, increasing the number of Drug-Drug Interactions (DDIs). To predict unknown DDIs, recently, studies started incorporating Knowledge Graphs (KGs) since they…

Artificial Intelligence · Computer Science 2023-08-14 Lizzy Farrugia , Lilian M. Azzopardi , Jeremy Debattista , Charlie Abela

The task of joint dialog sentiment classification (DSC) and act recognition (DAR) aims to simultaneously predict the sentiment label and act label for each utterance in a dialog. In this paper, we put forward a new framework which models…

Computation and Language · Computer Science 2022-03-09 Bowen Xing , Ivor W. Tsang

Objective. The impact of social determinants of health (SDoH) on patients' healthcare quality and the disparity is well-known. Many SDoH items are not coded in structured forms in electronic health records. These items are often captured in…

Computation and Language · Computer Science 2022-12-27 Xingmeng Zhao , Anthony Rios

Identification of drug-target interactions is an indispensable part of drug discovery. While conventional shallow machine learning and recent deep learning methods based on chemogenomic properties of drugs and target proteins have pushed…

Quantitative Methods · Quantitative Biology 2024-04-05 Yuanyuan Zhang , Yingdong Wang , Chaoyong Wu , Lingmin Zhana , Aoyi Wang , Caiping Cheng , Jinzhong Zhao , Wuxia Zhang , Jianxin Chen , Peng Li

Predicting drug-target interactions (DTI) is an essential part of the drug discovery process, which is an expensive process in terms of time and cost. Therefore, reducing DTI cost could lead to reduced healthcare costs for a patient. In…

Machine Learning · Computer Science 2019-08-20 Bonggun Shin , Sungsoo Park , Keunsoo Kang , Joyce C. Ho

Multi-label text classification involves extracting all relevant labels from a sentence. Given the unordered nature of these labels, we propose approaching the problem as a set prediction task. To address the correlation between labels, we…

Computation and Language · Computer Science 2024-03-15 Du Xinkai , Han Quanjie , Sun Yalin , Lv Chao , Sun Maosong
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