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The recent progress of linear-scaling or O(N) methods in the density functional theory (DFT) is remarkable. We expect that first-principles molecular dynamics (FPMD) simulations based on DFT can now treat more realistic and complex systems…

Materials Science · Physics 2014-11-11 Michiaki Arita , David R. Bowler , Tsuyoshi Miyazaki

The process of setting up and successfully running Molecular Dynamics Simulations (MDS) is outlined to be incredibly labour and computationally expensive with a very high barrier to entry for newcomers wishing to utilise the benefits and…

Computational Engineering, Finance, and Science · Computer Science 2025-03-17 Jai Geddes Nelson , Xiaochen Liu , Ken Tye Yong

For nearly the past 30 years, Centroid Molecular Dynamics (CMD) has proven to be a viable classical-like phase space formulation for the calculation of quantum dynamical properties. However, calculation of the centroid effective force…

Chemical Physics · Physics 2022-09-15 Timothy D. Loose , Patrick G. Sahrmann , Gregory A. Voth

DL_POLY Quantum 2.1 is introduced here as a highly modular, sustainable, and scalable general-purpose molecular dynamics (MD) simulation software for large-scale long-time MD simulations of condensed phase and interfacial systems with the…

Materials Science · Physics 2025-05-08 Nathan London , Dil K. Limbu , Md Omar Faruque , Farnaz A. Shakib , Mohammad R. Momeni

With the continuous growth of processing power for scientific computing, first principles Born-Oppenheimer molecular dynamics (MD) simulations are becoming increasingly popular for the study of a wide range of problems in materials science,…

Materials Science · Physics 2015-06-04 Anders M. N. Niklasson , Marc J. Cawkwell

Although event-driven algorithms have been shown to be far more efficient than time-driven methods such as conventional molecular dynamics, they have not become as popular. The main obstacle seems to be the difficulty of parallelizing…

Computational Physics · Physics 2015-06-26 S. Miller , S. Luding

We present an efficient open-source implementation of the multiparticle collision dynamics (MPCD) algorithm that scales to run on hundreds of graphics processing units (GPUs). We especially focus on optimizations for modern GPU…

Soft Condensed Matter · Physics 2018-08-01 Michael P. Howard , Athanassios Z. Panagiotopoulos , Arash Nikoubashman

Distributed point charge models (DCM) and their minimal variants (MDCM) have been integrated with tools widely used for condensed-phase simulations, including a virial-based barostat and a slow-growth algorithm for thermodynamic…

Chemical Physics · Physics 2020-11-03 Mike Devereux , Marco Pezzella , Shampa Raghunathan , Markus Meuwly

Numerous algorithms and parallelisations have been developed for short-range particle simulations; however, none are optimally performant for all scenarios. Such a concept led to the prior development of the particle simulation library…

Computational Engineering, Finance, and Science · Computer Science 2025-05-07 Samuel James Newcome , Fabio Alexander Gratl , Manuel Lerchner , Abdulkadir Pazar , Manish Kumar Mishra , Hans-Joachim Bungartz

Typical biomolecular systems such as cellular membranes, DNA, and protein complexes are highly charged. Thus, efficient and accurate treatment of electrostatic interactions is of great importance in computational modelling of such systems.…

Soft Condensed Matter · Physics 2007-05-23 Michael Patra , Marja T. Hyvonen , Emma Falck , Mohsen Sabouri-Ghomi , Ilpo Vattulainen , Mikko Karttunen

We present magneto-hydrodynamic simulation results for heterogeneous systems. Heterogeneous architectures combine high floating point performance many-core units hosted in conventional server nodes. Examples include Graphics Processing…

Performance · Computer Science 2010-11-04 Bijia Pang , Ue-li Pen , Michael Perrone

We develop a combined machine learning (ML) and quantum mechanics approach that enables data-efficient reconstruction of flexible molecular force fields from high-level ab initio calculations, through the consideration of fundamental…

Computational Physics · Physics 2021-04-14 Stefan Chmiela , Huziel E. Sauceda , Alexandre Tkatchenko , Klaus-Robert Müller

We propose a method for multi-scale hybrid simulations of molecular dynamics (MD) and computational fluid dynamics (CFD). In the method, usual lattice-mesh based simulations are applied for CFD level, but each lattice is associated with a…

Soft Condensed Matter · Physics 2014-01-20 Shugo Yasuda , Ryoichi Yamamoto

Molecular dynamics is widely used to study various phenomena, such as diffusion, shock wave propagation, and plasma dynamics. A wide range of software packages supports the expanding scope of molecular dynamics applications. However, the…

Computational Physics · Physics 2025-12-01 I. S. Galtsov , R. V. Muratov , G. V. Vyskvarko , S. A. Murzov , S. A. Dyachkov , P. R. Levashov

Only a small fraction of the data generated in state-of-the-art all-atom multi-microsecond molecular dynamics (MD) simulations is typically analyzed. With femtosecond integration steps, microsecond simulations generate billions of time…

This paper presents a molecular mechanics study using a molecular dynamics software (NAMD) coupled to virtual reality (VR) techniques for intuitive Bio-NanoRobotic prototyping. Using simulated Bio-Nano environments in VR, the operator can…

Biological Physics · Physics 2007-08-15 Mustapha Hamdi , Gaurav Sharma , A. Ferreira , Constantinos Mavroidis

Memory-centric computing aims to enable computation capability in and near all places where data is generated and stored. As such, it can greatly reduce the large negative performance and energy impact of data access and data movement, by…

Hardware Architecture · Computer Science 2024-12-30 Onur Mutlu , Ataberk Olgun , Geraldo F. Oliveira , Ismail Emir Yuksel

With their widespread availability, FPGA-based accelerators cards have become an alternative to GPUs and CPUs to accelerate computing in applications with certain requirements (like energy efficiency) or properties (like fixed-point…

Hardware Architecture · Computer Science 2022-10-20 Tom Vander Aa , Tom Haber , Thomas J. Ashby , Roel Wuyts , Wilfried Verachtert

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for a machine learning revolution and have already been profoundly impacted by the…

Chemical Physics · Physics 2019-11-11 Frank Noé , Alexandre Tkatchenko , Klaus-Robert Müller , Cecilia Clementi

Neural network-based molecular dynamics (NNMD) simulations incorporating long-range electrostatic interactions have significantly extended the applicability to heterogeneous and ionic systems, enabling effective modeling critical physical…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-23 Jianxiong Li , Beining Zhang , Mingzhen Li , Siyu Hu , Jinzhe Zeng , Lijun Liu , Guojun Yuan , Zhan Wang , Guangming Tan , Weile Jia