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High-throughput technologies such as next generation sequencing allow biologists to observe cell function with unprecedented resolution, but the resulting datasets are too large and complicated for humans to understand without the aid of…

Applications · Statistics 2021-10-08 David S. Watson

Causal machine learning (CML) has experienced increasing popularity in healthcare. Beyond the inherent capabilities of adding domain knowledge into learning systems, CML provides a complete toolset for investigating how a system would react…

Machine Learning · Computer Science 2022-06-01 Pedro Sanchez , Jeremy P. Voisey , Tian Xia , Hannah I. Watson , Alison Q. ONeil , Sotirios A. Tsaftaris

Remarkable success of modern image-based AI methods and the resulting interest in their applications in critical decision-making processes has led to a surge in efforts to make such intelligent systems transparent and explainable. The need…

Artificial Intelligence · Computer Science 2020-11-30 Adriano Lucieri , Muhammad Naseer Bajwa , Andreas Dengel , Sheraz Ahmed

New technologies have led to vast troves of large and complex datasets across many scientific domains and industries. People routinely use machine learning techniques to not only process, visualize, and make predictions from this big data,…

Machine Learning · Statistics 2023-08-04 Genevera I. Allen , Luqin Gan , Lili Zheng

Interpretability research on large language models (LLMs) has yielded important insights into model behaviour, yet recurring pitfalls persist: findings that do not generalise, and causal interpretations that outrun the evidence. Our…

Machine Learning · Computer Science 2026-03-20 Shruti Joshi , Aaron Mueller , David Klindt , Wieland Brendel , Patrik Reizinger , Dhanya Sridhar

Explainable Artificial Intelligence (AI) methods are designed to provide information about how AI-based models make predictions. In healthcare, there is a widespread expectation that these methods will provide relevant and accurate…

While explainable AI (XAI) is often heralded as a means to enhance transparency and trustworthiness in closed-loop neurotechnology for psychiatric and neurological conditions, its real-world prevalence remains low. Moreover, empirical…

Computers and Society · Computer Science 2026-03-20 Laura Schopp , Ambra DImperio , Jalal Etesami , Marcello Ienca

The importance of explainability in machine learning continues to grow, as both neural-network architectures and the data they model become increasingly complex. Unique challenges arise when a model's input features become high dimensional:…

Machine Learning · Computer Science 2021-12-21 Damien de Mijolla , Christopher Frye , Markus Kunesch , John Mansir , Ilya Feige

Large-scale AI models such as GPT-4 have accelerated the deployment of artificial intelligence across critical domains including law, healthcare, and finance, raising urgent questions about trust and transparency. This study investigates…

Artificial Intelligence · Computer Science 2025-10-20 Allen Daniel Sunny

Transformer language models are state of the art in a multitude of NLP tasks. Despite these successes, their opaqueness remains problematic. Recent methods aiming to provide interpretability and explainability to black-box models primarily…

Computation and Language · Computer Science 2022-03-14 Felix Friedrich , Patrick Schramowski , Christopher Tauchmann , Kristian Kersting

This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is…

Machine Learning · Computer Science 2018-05-15 Federico Cabitza , Davide Ciucci , Raffaele Rasoini

Deep Learning based models are currently dominating most state-of-the-art solutions for disease prediction. Existing works employ RNNs along with multiple levels of attention mechanisms to provide interpretability. These deep learning…

Machine Learning · Statistics 2022-06-01 Subhadip Maji , Raghav Bali , Sree Harsha Ankem , Kishore V Ayyadevara

We present a brief history of the field of interpretable machine learning (IML), give an overview of state-of-the-art interpretation methods, and discuss challenges. Research in IML has boomed in recent years. As young as the field is, it…

Machine Learning · Statistics 2022-01-24 Christoph Molnar , Giuseppe Casalicchio , Bernd Bischl

Recent developments in machine learning have introduced models that approach human performance at the cost of increased architectural complexity. Efforts to make the rationales behind the models' predictions transparent have inspired an…

Computation and Language · Computer Science 2020-09-29 Pepa Atanasova , Jakob Grue Simonsen , Christina Lioma , Isabelle Augenstein

Causal relationships play a pivotal role in research within the field of public administration. Ensuring reliable causal inference requires validating the predictability of these relationships, which is a crucial precondition. However,…

Computers and Society · Computer Science 2026-01-13 Zhanyu Liu , Yang Yu

As large language models (LLMs) are increasingly deployed in sensitive domains such as healthcare, law, and education, the demand for transparent, interpretable, and accountable AI systems becomes more urgent. Explainable AI (XAI) acts as a…

Computers and Society · Computer Science 2025-05-28 Francisco Herrera

Machine learning (ML) models are nowadays used in complex applications in various domains, such as medicine, bioinformatics, and other sciences. Due to their black box nature, however, it may sometimes be hard to understand and trust the…

Machine Learning · Computer Science 2024-04-19 A. Chatzimparmpas , R. Martins , I. Jusufi , K. Kucher , Fabrice Rossi , A. Kerren

Despite widespread adoption, machine learning models remain mostly black boxes. Understanding the reasons behind predictions is, however, quite important in assessing trust, which is fundamental if one plans to take action based on a…

Machine Learning · Computer Science 2016-08-10 Marco Tulio Ribeiro , Sameer Singh , Carlos Guestrin

Modern data analytics underpinned by machine learning techniques has become a key enabler to the automation of data-led decision making. As an important branch of state-of-the-art data analytics, business process predictions are also faced…

Artificial Intelligence · Computer Science 2021-07-22 Chun Ouyang , Renuka Sindhgatta , Catarina Moreira

Application of interpretable machine learning techniques on medical datasets facilitate early and fast diagnoses, along with getting deeper insight into the data. Furthermore, the transparency of these models increase trust among…

Machine Learning · Computer Science 2025-06-05 Sreejita Ghosh , Elizabeth S. Baranowski , Michael Biehl , Wiebke Arlt , Peter Tino , Kerstin Bunte
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