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This article introduces a new methodology for reconstructing the white matter fiber pathways of brain in diffusion MRI. Usually, the signal intensity values will be lesser in the direction of higher diffusivity. The proposed approach picks…

Neurons and Cognition · Quantitative Biology 2022-07-26 Ashishi Puri , Sanjeev Kumar

In this work, we explore the various Brain Neuron tracking techniques, which is one of the most significant applications of Diffusion Tensor Imaging. Tractography provides us with a non-invasive method to analyze underlying tissue…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Nandakishore Puttashamachar , Ulas Bagci

Multi-compartment modeling of diffusion-weighted magnetic resonance imaging measurements is necessary for accurate brain connectivity analysis. Existing methods for estimating the number and orientations of fascicles in an imaging voxel…

Image and Video Processing · Electrical Eng. & Systems 2020-06-22 Davood Karimi , Lana Vasung , Camilo Jaimes , Fedel Machado-Rivas , Shadab Khan , Simon K. Warfield , Ali Gholipour

Fiber orientation distribution (FOD) is an advanced diffusion MRI modeling technique that represents complex white matter fiber configurations, and a key step for subsequent brain tractography and connectome analysis. Its reliability and…

Tractography traces the peak directions extracted from fiber orientation distribution (FOD) suffering from ambiguous spatial correspondences between diffusion directions and fiber geometry, which is prone to producing erroneous tracks while…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Yuanjing Feng , Lei Xie , Jingqiang Wang , Qiyuan Tian , Jianzhong He , Qingrun Zeng , Fei Gao

Diffusion MRI (dMRI) tractography is currently the only method for in vivo mapping of the brain's white matter (WM) connections. Tractometry is an advanced tractography analysis technique for along-tract profiling to investigate the…

Quantitative Methods · Quantitative Biology 2026-01-29 Ruixi Zheng , Wei Zhang , Yijie Li , Xi Zhu , Zhou Lan , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Lauren J. O'Donnell , Fan Zhang

Fiber tractography is a cornerstone of neuroimaging, enabling the detailed mapping of the brain's white matter pathways through diffusion MRI. This is crucial for understanding brain connectivity and function, making it a valuable tool in…

Machine Learning · Computer Science 2024-11-15 Ankita Joshi , Ashutosh Sharma , Anoushkrit Goel , Ranjeet Ranjan Jha , Chirag Ahuja , Arnav Bhavsar , Aditya Nigam

Diffusion MRI tractography is an advanced imaging technique for quantitative mapping of the brain's structural connectivity. Whole brain tractography (WBT) data contains over hundreds of thousands of individual fiber streamlines (estimated…

Image and Video Processing · Electrical Eng. & Systems 2022-07-12 Fan Zhang , Tengfei Xue , Weidong Cai , Yogesh Rathi , Carl-Fredrik Westin , Lauren J O'Donnell

Processing of Diffusion MRI data obtained from High Angular Resolution measurements consists of a series of steps, starting with the estimation of an orientation distribution function (ODF), which is then used as input for e.g. tractography…

Numerical Analysis · Mathematics 2015-12-23 T. Hohage , C. Rügge

Fiber tractography is an important tool of computational neuroscience that enables reconstructing the spatial connectivity and organization of white matter of the brain. Fiber tractography takes advantage of diffusion Magnetic Resonance…

Image and Video Processing · Electrical Eng. & Systems 2020-09-08 Tomer Weiss , Sanketh Vedula , Ortal Senouf , Oleg Michailovich , AlexBronstein

Diffusion MRI (dMRI) is a critical non-invasive technique to estimate fiber orientation distribution (FOD) for characterizing white matter integrity. Estimating FOD from single-shell low angular resolution dMRI (LAR-FOD) is limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Hao Tang , Hanyu Liu , Alessandro Perelli , Xi Chen , Chao Li

Diffusion-weighted Magnetic Resonance Imaging (dMRI) is increasingly used to study the fetal brain in utero. An important computation enabled by dMRI is streamline tractography, which has unique applications such as tract-specific analysis…

Computer Vision and Pattern Recognition · Computer Science 2024-03-06 Camilo Calixto , Camilo Jaimes , Matheus D. Soldatelli , Simon K. Warfield , Ali Gholipour , Davood Karimi

The individual course of white matter fiber tracts is an important key for analysis of white matter characteristics in healthy and diseased brains. Uniquely, diffusion-weighted MRI tractography in combination with region-based or…

Computer Vision and Pattern Recognition · Computer Science 2018-08-21 Jakob Wasserthal , Peter Neher , Klaus H. Maier-Hein

Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby…

Diffusion-weighted MR imaging (DWI) is the only method we currently have to measure connections between different parts of the human brain in vivo. To elucidate the structure of these connections, algorithms for tracking bundles of axonal…

Machine Learning · Statistics 2014-12-05 Charles Zheng , Franco Pestilli , Ariel Rokem

In this paper, we propose a novel large deformation diffeomorphic registration algorithm to align high angular resolution diffusion images (HARDI) characterized by orientation distribution functions (ODFs). Our proposed algorithm seeks an…

Computer Vision and Pattern Recognition · Computer Science 2011-07-26 Jia Du , Alvina Goh , Anqi Qiu

Diffusion-weighted magnetic resonance imaging (dMRI) is the only non-invasive tool for studying white matter tracts and structural connectivity of the brain. These assessments rely heavily on tractography techniques, which reconstruct…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Weide Liu , Camilo Calixto , Simon K. Warfield , Davood Karimi

Magnetic Resonance Fingerprinting (MRF) enables the simultaneous quantification of multiple properties of biological tissues. It relies on a pseudo-random acquisition and the matching of acquired signal evolutions to a precomputed…

Models of diffusion MRI within a voxel are useful for making inferences about the properties of the tissue and inferring fiber orientation distribution used by tractography algorithms. A useful model must fit the data accurately. However,…

Quantitative Methods · Quantitative Biology 2017-02-08 Ariel Rokem , Jason D. Yeatman , Franco Pestilli , Kendrick N. Kay , Aviv Mezer , Stefan van der Walt , Brian A. Wandell

Identifying and characterizing brain fiber bundles can help to understand many diseases and conditions. An important step in this process is the estimation of fiber orientations using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI).…

Image and Video Processing · Electrical Eng. & Systems 2024-02-20 Mateus Oliveira da Silva , Caio Pinheiro Santana , Diedre Santos do Carmo , Letícia Rittner