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We study dynamical properties of confined, self-propelled Brownian particles in an inhomogeneous activity profile. Using Brownian dynamics simulations, we calculate the probability to reach a fixed target and the mean first passage time to…

Soft Condensed Matter · Physics 2019-08-30 Hidde Vuijk , Abhinav Sharma , Debasish Mondal , Jens-Uwe Sommer , Holger Merlitz

In this paper, we consider the dynamics of a 2D target-searching agent performing Brownian motion under the influence of fluid shear flow and chemical attraction. The analysis is motivated by numerous situations in biology where these…

Probability · Mathematics 2022-05-31 Yishu Gong , Siming He , Alexander Kiselev

We theoretically address minimal search strategies of active, self-propelled particles towards hidden targets in three-dimensional space. The particles can sense if a target is close, e.g., by detecting signaling molecules released by a…

Soft Condensed Matter · Physics 2021-03-22 Justus A. Kromer , Andrea Auconi , Benjamin M. Friedrich

Cell migration often exhibits long-range temporal correlations and anomalous diffusion, even in the absence of external guidance cues such as chemical gradients or topographical constraints. These observations raise a fundamental question:…

Quantitative Methods · Quantitative Biology 2025-11-25 Gustavo Cornejo-Olea , Lucas Buvinic , Jerome Darbon , Radek Erban , Andrea Ravasio , Anastasios Matzavinos

Target search by active agents in rugged energy landscapes has remained a challenge because standard enhanced sampling methods do not apply to irreversible dynamics. We overcome this non-equilibrium rare-event problem by developing an…

Soft Condensed Matter · Physics 2021-01-20 Luigi Zanovello , Michele Caraglio , Thomas Franosch , Pietro Faccioli

In this review, we present the encounter-based approach to target search problems, in which the diffusive dynamics is described by the joint probability of the position of the particle and the number of its encounters with a given target…

Statistical Mechanics · Physics 2025-07-16 Denis S. Grebenkov

Finding the best strategy to minimize the time needed to find a given target is a crucial task both in nature and in reaching decisive technological advances. By considering learning agents able to switch their dynamics between standard and…

A discrete chemotactic predator-prey model is proposed in which the prey secrets a diffusing chemical which is sensed by the predator and vice versa. Two dynamical states corresponding to catching and escaping are identified and it is shown…

Populations and Evolution · Quantitative Biology 2015-05-20 Ankush Sengupta , Tobias Kruppa , Hartmut Löwen

Stochastic resetting has recently emerged as an efficient target-searching strategy in various physical and biological systems. The efficiency of this strategy depends on the type of environmental noise, whether it is thermal or telegraphic…

Statistical Mechanics · Physics 2024-07-08 Priyo Shankar Pal , Jong-Min Park , Arnab Pal , Hyunggyu Park , Jae Sung Lee

We consider a moving target and an active pursing agent, modeled as an intelligent active Brownian particle capable of sensing the instantaneous target location and adjust its direction of motion accordingly. An analytical and simulation…

Soft Condensed Matter · Physics 2024-06-04 Segun Goh , Roland G. Winkler , Gerhard Gompper

In many situations, simply finding a target during a search is not enough. It is equally important to be able to return to that target repeatedly or to enable a larger community to locate and utilize it. While first passage time is commonly…

Soft Condensed Matter · Physics 2025-07-16 Vladimir Yu. Rudyak , Shahar Shinehorn , Yael Roichman

We study the target search of interacting Brownian particles in a finite domain, focusing on the effect of inter-particle interactions on the search time. We derive the integral equation for the mean first-passage time and acquire its…

Statistical Mechanics · Physics 2023-07-12 Sunghan Ro , Juyeon Yi , Yong Woon Kim

In this work, we study the dynamics of a single active Brownian particle, as well as the collective behavior of interacting active Brownian particles, in a fluctuating heterogeneous environment. We employ a variant of the diffusing…

Soft Condensed Matter · Physics 2022-01-05 S. M. J. Khadem , N. H. Siboni , S. H. L. Klapp

In olfactory search an immobile target emits chemical molecules at constant rate. The molecules are transported by the medium which is assumed to be turbulent. Considering a searcher able to detect such chemical signals and whose motion…

Statistical Mechanics · Physics 2014-02-12 Juan Duque-Rodríguez , David Gómez-Ullate , Carlos Mejía-Monasterio

The Brownian dynamics of a single microorganism coupled by chemotaxis to a diffusing concentration field which is secreted by the microorganism itself is studied by computer simulations in spatial dimensions $d=1,2,3$. Both cases of a…

Soft Condensed Matter · Physics 2015-05-13 Ankush Sengupta , Sven van Teeffelen , Hartmut Löwen

Recent experiments with self-phoretic particles at low concentrations show a pronounced dynamic clustering [I. Theurkauff \emph{et al.}, Phys.\ Rev.\ Lett.\ \textbf{108}, 268303 (2012)]. We model this situation by taking into account the…

Soft Condensed Matter · Physics 2015-06-19 Oliver Pohl , Holger Stark

We investigate exploration patterns of a microswimmer, modeled as an active Brownian particle, searching for a target region located in a well of an energy landscape and separated from the initial position of the particle by high barriers.…

Soft Condensed Matter · Physics 2021-09-02 Luigi Zanovello , Pietro Faccioli , Thomas Franosch , Michele Caraglio

Active particles, which are self-propelled nonequilibrium systems, are modelled by overdamped Langevin equations with colored noise, emulating the self-propulsion. In this chapter, we present a review of the theoretical results for the…

Statistical Mechanics · Physics 2025-03-12 Urna Basu , Sanjib Sabhapandit , Ion Santra

Through evolution, bacteria have developed the ability to perform chemotactic motion in order to find nourishment. By adopting a machine learning approach, we aim to understand how this behavior arises. We consider run-and-tumble agents…

Soft Condensed Matter · Physics 2026-01-13 Nicholas Tovazzi , Gorka Muñoz-Gil , Michele Caraglio

Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid re-arrangements of the medium constantly change the effective diffusivity felt…

Statistical Mechanics · Physics 2019-11-13 Yann Lanoiselée , Nicolas Moutal , Denis S. Grebenkov
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