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Background: In epidemiology, causal inference and prediction modeling methodologies have been historically distinct. Directed Acyclic Graphs (DAGs) are used to model a priori causal assumptions and inform variable selection strategies for…

Methodology · Statistics 2020-07-03 Marco Piccininni , Stefan Konigorski , Jessica L Rohmann , Tobias Kurth

Large Language Models (LLMs) have achieved impressive performance in complex reasoning problems. Their effectiveness highly depends on the specific nature of the task, especially the required domain knowledge. Existing approaches, such as…

Multiagent Systems · Computer Science 2025-11-20 Jiangwen Dong , Zehui Lin , Wanyu Lin , Mingjin Zhang

Speculative decoding has emerged as a promising technique to accelerate the inference of Large Language Models (LLMs) by employing a small language model to draft a hypothesis sequence, which is then validated by the LLM. The effectiveness…

Computation and Language · Computer Science 2024-07-24 Zhuocheng Gong , Jiahao Liu , Ziyue Wang , Pengfei Wu , Jingang Wang , Xunliang Cai , Dongyan Zhao , Rui Yan

When designing new molecules with particular properties, it is not only important what to make but crucially how to make it. These instructions form a synthesis directed acyclic graph (DAG), describing how a large vocabulary of simple…

Machine Learning · Computer Science 2020-12-22 John Bradshaw , Brooks Paige , Matt J. Kusner , Marwin H. S. Segler , José Miguel Hernández-Lobato

We consider the PC-algorithm Spirtes et. al. (2000) for estimating the skeleton of a very high-dimensional acyclic directed graph (DAG) with corresponding Gaussian distribution. The PC-algorithm is computationally feasible for sparse…

Statistics Theory · Mathematics 2007-06-13 Markus Kalisch , Peter Buehlmann

A model, called the linear transform network (LTN), is proposed to analyze the compression and estimation of correlated signals transmitted over directed acyclic graphs (DAGs). An LTN is a DAG network with multiple source and receiver…

Information Theory · Computer Science 2015-04-15 Naveen Goela , Michael Gastpar

In this paper, we propose a learning-to-optimize (L2O) framework to accelerate solving parametric mixed-integer quadratic programming (MIQP) problems, with a particular focus on mixed-integer model predictive control (MI-MPC) applications.…

Systems and Control · Electrical Eng. & Systems 2026-05-14 Viet-Anh Le , Mu Xie , Rahul Mangharam

Learning the structure of dependence relations between variables is a pervasive issue in the statistical literature. A directed acyclic graph (DAG) can represent a set of conditional independences, but different DAGs may encode the same set…

Methodology · Statistics 2021-02-15 Federico Castelletti , Stefano Peluso

A DAG compression of a (typically dense) graph is a simple data structure that stores how vertex clusters are connected, where the clusters are described indirectly as sets of reachable sinks in a directed acyclic graph (DAG). They…

Data Structures and Algorithms · Computer Science 2026-03-24 Florian Chudigiewitsch , Till Tantau , Felix Winkler

Recently, reinforcement learning (RL) has proved a promising alternative for conventional local heuristics in score-based approaches to learning directed acyclic causal graphs (DAGs) from observational data. However, the intricate…

Machine Learning · Computer Science 2025-06-02 Bao Duong , Hung Le , Biwei Huang , Thin Nguyen

Learning a graph topology to reveal the underlying relationship between data entities plays an important role in various machine learning and data analysis tasks. Under the assumption that structured data vary smoothly over a graph, the…

Machine Learning · Statistics 2023-08-23 Xingyue Pu , Tianyue Cao , Xiaoyun Zhang , Xiaowen Dong , Siheng Chen

Neural networks (NNs) achieve outstanding performance in many domains; however, their decision processes are often opaque and their inference can be computationally expensive in resource-constrained environments. We recently proposed…

Machine Learning · Computer Science 2025-05-30 Chang Yue , Niraj K. Jha

A regularized version of Mixture Models is proposed to learn a principal graph from a distribution of $D$-dimensional data points. In the particular case of manifold learning for ridge detection, we assume that the underlying manifold can…

Machine Learning · Computer Science 2023-07-13 Tony Bonnaire , Aurélien Decelle , Nabila Aghanim

New biological assays like Perturb-seq link highly parallel CRISPR interventions to a high-dimensional transcriptomic readout, providing insight into gene regulatory networks. Causal gene regulatory networks can be represented by directed…

Machine Learning · Statistics 2024-02-22 Albert Xue , Jingyou Rao , Sriram Sankararaman , Harold Pimentel

A directed acyclic graph (DAG) is the most common graphical model for representing causal relationships among a set of variables. When restricted to using only observational data, the structure of the ground truth DAG is identifiable only…

Data Structures and Algorithms · Computer Science 2018-09-12 AmirEmad Ghassami , Saber Salehkaleybar , Negar Kiyavash , Kun Zhang

We propose a method to identify nonlinear acyclic networks in continuous time when the dynamics are located on the edges and all the nodes are excited. We show that it is necessary and sufficient to measure all the sinks to identify any…

Optimization and Control · Mathematics 2026-03-05 Ramachandran Anantharaman , Renato Vizuete , Julien M. Hendrickx , Alexandre Mauroy

Learning a Bayesian network (BN) from data can be useful for decision-making or discovering causal relationships. However, traditional methods often fail in modern applications, which exhibit a larger number of observed variables than data…

Computation · Statistics 2018-06-26 Raj Agrawal , Tamara Broderick , Caroline Uhler

A recent approach to building consensus protocols on top of Directed Acyclic Graphs (DAGs) shows much promise due to its simplicity and stable throughput. However, as each node in the DAG typically includes a linear number of references to…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-03 Michael Anoprenko , Andrei Tonkikh , Alexander Spiegelman , Petr Kuznetsov , Anatoliy Zinovyev , Konstantin Shprenger

Discovering causal structures from data is a challenging inference problem of fundamental importance in all areas of science. The appealing properties of neural networks have recently led to a surge of interest in differentiable neural…

A directed acyclic graph (DAG) provides valuable prior knowledge that is often discarded in regression tasks in machine learning. We show that the independences arising from the presence of collider structures in DAGs provide meaningful…

Machine Learning · Statistics 2023-06-22 Shahine Bouabid , Jake Fawkes , Dino Sejdinovic