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Related papers: Fractional Calculus in Pharmacokinetics

200 papers

We review recent results obtained to solve fractional order optimal control problems with free terminal time and a dynamic constraint involving integer and fractional order derivatives. Some particular cases are studied in detail. A…

Optimization and Control · Mathematics 2013-06-04 Shakoor Pooseh , Ricardo Almeida , Delfim F. M. Torres

This article analysis differential equations which represents damped and fractional oscillators. First, it is shown that prior to using physical quantities in fractional calculus, it is imperative that they are turned dimensionless.…

A lot of criticism against the standard formulation of pharmacokinetics has been raised by several authors. It seems that the natural reaction for that criticism is to comment it from the point of view of the theory of conservation laws.…

Quantitative Methods · Quantitative Biology 2012-10-15 S. Piekarski , M. Rewekant

This paper deals with fractional-order controlled systems and fractional-order controllers in the discrete domain. The mathematical description by the fractional difference equations and properties of these systems are presented. A…

Optimization and Control · Mathematics 2007-05-23 I. Petras , L. Dorcak , I. Kostial

Digital System Research has pioneered the mathematics and design for a new class of computing machine using residue numbers. Unlike prior art, the new breakthrough provides methods and apparatus for general purpose computation using several…

Other Computer Science · Computer Science 2015-12-04 Eric B. Olsen

Fractional order models have proven to be a very useful tool for the modeling of the mechanical behaviour of viscoelastic materials. Traditional numerical solution methods exhibit various undesired properties due to the non-locality of the…

Numerical Analysis · Mathematics 2023-01-30 Kai Diethelm

Medication adherence is a well-known problem for pharmaceutical treatment of chronic diseases. Understanding how nonadherence affects treatment efficacy is made difficult by the ethics of clinical trials that force patients to skip doses of…

Quantitative Methods · Quantitative Biology 2021-12-30 Elijah D Counterman , Sean D Lawley

In this study, we explore the field of physics through the lens of fractional dimensionality. We propose that space is not confined to integer dimensions alone, but can also be understood as a superposition of spaces that exist between…

General Physics · Physics 2026-03-24 Ali Dorostkar

Our study focuses on fractional order compartment models derived from underlying physical stochastic processes, providing a more physically grounded approach compared to models that use the dynamical system approach by simply replacing…

Multi-system interaction is an important and difficult problem in physics. Motivated by the experimental result of an electronic circuit element "Fractor", we introduce the concept of dynamic-order fractional dynamic system, in which the…

Mathematical Physics · Physics 2013-04-10 HongGuang Sun , Hu Sheng , YangQuan Chen , Wen Chen , ZhongBo Yu

We introduce a notion of fractional (noninteger order) derivative on an arbitrary nonempty closed subset of the real numbers (on a time scale). Main properties of the new operator are proved and several illustrative examples given.

Classical Analysis and ODEs · Mathematics 2016-09-06 Benaoumeur Bayour , Delfim F. M. Torres

This study makes the first attempt to use the 2/3-order fractional Laplacian modeling of enhanced diffusing movements of random turbulent particle resulting from nonlinear inertial interactions. A combined effect of the inertial…

Chaotic Dynamics · Physics 2007-05-23 Wen Chen

We present a theoretical and computational framework based on fractional calculus for the analysis of the nonlocal static response of cylindrical shell panels. The differ-integral nature of fractional derivatives allows an efficient and…

Computational Engineering, Finance, and Science · Computer Science 2022-06-29 Sai Sidhardh , Sansit Patnaik , Fabio Semperlotti

In this paper, we use the fractional calculus to discuss the fractional mechanics, where the time derivative is replaced with the fractional derivative of order $\nu$. We deal with the motion of a body in a resisting medium where the…

General Physics · Physics 2015-06-15 Won Sang Chung , Min Jung

Fractional calculus has been used to describe physical systems with complexity. Here, we show that a fractional calculus approach can restore or include complexity in any physical systems that can be described by partial differential…

Mesoscale and Nanoscale Physics · Physics 2024-08-06 Kyle Rockwell , Ezio Iacocca

The area of fractional calculus (FC) has been fast developing and is presently being applied in all scientific fields. Therefore, it is of key relevance to assess the present state of development and to foresee, if possible, the future…

Classical Analysis and ODEs · Mathematics 2022-02-15 Kai Diethelm , Virginia Kiryakova , Yuri Luchko , J. A. Tenreiro Machado , Vasily E. Tarasov

In this study, the Van't Hoff differential equation is taken under consideration by making use of fractional derivative tools. In this context, the nonlinear Arrhenius behaviour can be obtained and some experimental values of reaction rate…

Chemical Physics · Physics 2016-03-23 Nelson H. T. Lemes , Valentino A. Simpao , José P. C. dos Santos

This paper deals with fractional differential equations, with dependence on a Caputo fractional derivative of real order. The goal is to show, based on concrete examples and experimental data from several experiments, that fractional…

General Mathematics · Mathematics 2016-11-03 Ricardo Almeida , Nuno R. O. Bastos , M. Teresa T. Monteiro

In this paper, a new fractional order generalization of the classical Windkessel arterial model is developed to describe the aortic input impedance as an assessment of the left ventricular after-load. The proposed models embeds…

Tissues and Organs · Quantitative Biology 2019-08-15 Mohamed A. Bahloul , Taous-Meriem Laleg Kirati

Fractional order differential and difference equations are used to model systems with memory. Variable order fractional equations are proposed to model systems where the memory changes in time. We investigate stability conditions for linear…

Dynamical Systems · Mathematics 2025-02-12 Prashant M. Gade , Sachin Bhalekar , Janardhan Chevala