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Circulating tumor cells (CTCs) are crucial biomarkers in liquid biopsy, offering a noninvasive tool for cancer patient management. However, their identification remains particularly challenging due to their limited number and heterogeneity.…

Image and Video Processing · Electrical Eng. & Systems 2025-11-24 Martina Russo , Giulia Bertolini , Vera Cappelletti , Cinzia De Marco , Serena Di Cosimo , Petra Paiè , Nadia Brancati

Deep learning has achieved unprecedented success in various object detection tasks with huge amounts of labeled data. However, obtaining large-scale annotations for medical images is extremely challenging due to the high demand of labour…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Zhizhong Chai , Luyang Luo , Huangjing Lin , Hao Chen , Anjia Han , Pheng-Ann Heng

Oral cancer incidence is rapidly increasing worldwide. The most important determinant factor in cancer survival is early diagnosis. To facilitate large scale screening, we propose a fully automated pipeline for oral cancer detection on…

Image and Video Processing · Electrical Eng. & Systems 2020-09-14 Jiahao Lu , Nataša Sladoje , Christina Runow Stark , Eva Darai Ramqvist , Jan-Michaél Hirsch , Joakim Lindblad

Real-time tool segmentation is an essential component in computer-assisted surgical systems. We propose a novel real-time automatic method based on Fully Convolutional Networks (FCN) and optical flow tracking. Our method exploits the…

Deep learning has been shown to be useful to detect breast cancer metastases by analyzing whole slide images of sentinel lymph nodes. However, it requires extensive scanning and analysis of all the lymph nodes slides for each case. Our deep…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Kareem Allam , Xiaohong Iris Wang , Songlin Zhang , Jianmin Ding , Kevin Chiu , Karan Saluja , Amer Wahed , Hongxia Sun , Andy N. D. Nguyen

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

To address the issues of limited samples, time-consuming feature design, and low accuracy in detection and classification of breast cancer pathological images, a breast cancer image classification model algorithm combining deep learning and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-12 Weimin Wang , Yufeng Li , Xu Yan , Mingxuan Xiao , Min Gao

Data cleaning consumes about 80% of the time spent on data analysis for clinical research projects. This is a much bigger problem in the era of big data and machine learning in the field of medicine where large volumes of data are being…

Medical Physics · Physics 2018-01-03 Timothy Rozario , Troy Long , Mingli Chen , Weiguo Lu , Steve Jiang

This paper shows the machine learning system which performs instance segmentation of cytological images in veterinary medicine. Eleven cell types were used directly and indirectly in the experiments, including damaged and unrecognized…

In life sciences, fluorescent labeling techniques are used to study molecular structures and interactions of cells. However, this type of cell imaging has its own limitations, one of which is that the process of staining the cells could be…

Image and Video Processing · Electrical Eng. & Systems 2020-05-07 Eunjae Kim

In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Abdelmageed Ahmed , Alaa Nagy , Ahmed Kamal , Daila Farghl

State-of-the-art, high capacity deep neural networks not only require large amounts of labelled training data, they are also highly susceptible to label errors in this data, typically resulting in large efforts and costs and therefore…

Machine Learning · Computer Science 2020-07-20 Christian Haase-Schütz , Rainer Stal , Heinz Hertlein , Bernhard Sick

Time series analysis is a field of data science which is interested in analyzing sequences of numerical values ordered in time. Time series are particularly interesting because they allow us to visualize and understand the evolution of a…

Machine Learning · Computer Science 2020-10-02 Hassan Ismail Fawaz

A fundamental challenge in neuroscience is to understand what structure in the world is represented in spatially distributed patterns of neural activity from multiple single-trial measurements. This is often accomplished by learning a…

Neural and Evolutionary Computing · Computer Science 2020-07-01 Jesse A. Livezey , Kristofer E. Bouchard , Edward F. Chang

Segmenting blood vessels in fundus imaging plays an important role in medical diagnosis. Many algorithms have been proposed. While deep Neural Networks have been attracting enormous attention from computer vision community recent years and…

Computer Vision and Pattern Recognition · Computer Science 2017-05-02 Yongliang Chen

We present a foundation modeling framework that leverages deep learning to uncover latent genetic signatures across the hematopoietic hierarchy. Our approach trains a fully connected autoencoder on multipotent progenitor cells, reducing…

Machine Learning · Computer Science 2025-03-27 Gabriel Bo , Justin Gu , Christopher Sun

A device capable of performing real time classification of proteins in a clinical setting would allow for inexpensive and rapid disease diagnosis. One such candidate for this technology are nanopore devices. These devices work by measuring…

Machine Learning · Computer Science 2025-09-18 Samuel Tovey , Julian Hoßbach , Sandro Kuppel , Tobias Ensslen , Jan C. Behrends , Christian Holm

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Diagnosing diseases such as leukemia or anemia requires reliable counts of blood cells. Hematologists usually label and count microscopy images of blood cells manually. In many cases, however, cells in different maturity states are…

Machine Learning · Computer Science 2020-07-13 Yushan Liu , Markus M. Geipel , Christoph Tietz , Florian Buettner

Bone marrow cytology is required to make a hematological diagnosis, influencing critical clinical decision points in hematology. However, bone marrow cytology is tedious, limited to experienced reference centers and associated with high…

Image and Video Processing · Electrical Eng. & Systems 2021-07-09 Rohollah Moosavi Tayebi , Youqing Mu , Taher Dehkharghanian , Catherine Ross , Monalisa Sur , Ronan Foley , Hamid R. Tizhoosh , Clinton JV Campbell