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Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…

Quantitative Methods · Quantitative Biology 2024-03-05 Richard G. Carson , Alexander Leemans

Diffusion tractography is routinely used to study white matter architecture and brain connectivity in vivo. A key step for successful tractography of neuronal tracts is the correct identification of tract directions in each voxel. Here we…

To study axonal microstructure with diffusion MRI, axons are typically modeled as straight impermeable cylinders, whereby the transverse diffusion MRI signal can be made sensitive to the cylinder's inner diameter. However, the shape of a…

Medical Physics · Physics 2020-08-18 Hong-Hsi Lee , Sune N. Jespersen , Els Fieremans , Dmitry S. Novikov

Purpose: In diffusion MRI (dMRI), the volumetric and bundle analyses of whole-brain tissue microstructure and connectivity can be severely impeded by an incomplete field-of-view (FOV). This work aims to develop a method for imputing the…

Saliency maps have been widely used to interpret deep learning classifiers for Alzheimer's disease (AD). However, since AD is heterogeneous and has multiple subtypes, the pathological mechanism of AD remains not fully understood and may…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Yihan Zhang , Xuanshuo Zhang , Wei Wu , Haohan Wang

Fiber tractography is an important tool of computational neuroscience that enables reconstructing the spatial connectivity and organization of white matter of the brain. Fiber tractography takes advantage of diffusion Magnetic Resonance…

Image and Video Processing · Electrical Eng. & Systems 2020-09-08 Tomer Weiss , Sanketh Vedula , Ortal Senouf , Oleg Michailovich , AlexBronstein

In medicine, treatments often influence multiple, interdependent outcomes, such as primary endpoints, complications, adverse events, or other secondary endpoints. Hence, to make optimal treatment decisions, clinicians are interested in…

Machine Learning · Computer Science 2025-06-03 Yuchen Ma , Jonas Schweisthal , Hengrui Zhang , Stefan Feuerriegel

Dielectric spectra of human blood reveal a rich variety of dynamic processes. Achieving a better characterization and understanding of these processes not only is of academic interest but also of high relevance for medical applications as,…

Biological Physics · Physics 2015-03-13 M. Wolf , R. Gulich , P. Lunkenheimer , A. Loidl

Diffuse correlation spectroscopy (DCS) is a noninvasive optical technique that probes microvascular blood flow in deep tissues. Here, we present and validate a new on-chip hardware correlator for high-speed DCS measurements. The correlator…

Development of successful therapies for neurological disorders depends on our ability to diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to…

Biological Physics · Physics 2016-09-30 Jelle Veraart , Els Fieremans , Dmitry S. Novikov

Out-of-distribution (OOD) detection is crucial for the safety and reliability of artificial intelligence algorithms, especially in the medical domain. In the context of the Medical OOD (MOOD) detection challenge 2023, we propose a pipeline…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Evi M. C. Huijben , Sina Amirrajab , Josien P. W. Pluim

Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to…

Neurons and Cognition · Quantitative Biology 2017-10-17 Jeremy Guillon , Yohan Attal , Olivier Colliot , Valentina La Corte , Bruno Dubois , Denis Schwartz , Mario Chavez , Fabrizio De Vico Fallani

Diffusion-weighted Magnetic Resonance Imaging (dMRI) is increasingly used to study the fetal brain in utero. An important computation enabled by dMRI is streamline tractography, which has unique applications such as tract-specific analysis…

Computer Vision and Pattern Recognition · Computer Science 2024-03-06 Camilo Calixto , Camilo Jaimes , Matheus D. Soldatelli , Simon K. Warfield , Ali Gholipour , Davood Karimi

Multimodal medical images play a crucial role in the precise and comprehensive clinical diagnosis. Diffusion model is a powerful strategy to synthesize the required medical images. However, existing approaches still suffer from the problem…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Jiahua Xu , Dawei Zhou , Lei Hu , Zaiyi Liu , Nannan Wang , Xinbo Gao

Models of diffusion MRI within a voxel are useful for making inferences about the properties of the tissue and inferring fiber orientation distribution used by tractography algorithms. A useful model must fit the data accurately. However,…

Quantitative Methods · Quantitative Biology 2017-02-08 Ariel Rokem , Jason D. Yeatman , Franco Pestilli , Kendrick N. Kay , Aviv Mezer , Stefan van der Walt , Brian A. Wandell

Data-dependent metrics are powerful tools for learning the underlying structure of high-dimensional data. This article develops and analyzes a data-dependent metric known as diffusion state distance (DSD), which compares points using a…

Machine Learning · Statistics 2020-03-10 Lenore Cowen , Kapil Devkota , Xiaozhe Hu , James M. Murphy , Kaiyi Wu

Weakly supervised medical image segmentation (MIS) using generative models is crucial for clinical diagnosis. However, the accuracy of the segmentation results is often limited by insufficient supervision and the complex nature of medical…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Zhihao Shuai , Yinan Chen , Shunqiang Mao , Yihan Zho , Xiaohong Zhang

Autism Spectrum Disorder (ASD) is a developmental disorder that often impairs a child's normal development of the brain. According to CDC, it is estimated that 1 in 6 children in the US suffer from development disorders, and 1 in 68…

Signal Processing · Electrical Eng. & Systems 2019-07-03 Yasith Jayawardana , Mark Jaime , Sashi Thapaliya , Sampath Jayarathna

The time dependency of the diffusion coefficient of particles in porous media is an efficient probe of their geometry. The analysis of this quantity, measured e.g. by nuclear magnetic resonance (PGSE-NMR), can provide rich information…

Soft Condensed Matter · Physics 2013-02-13 Maximilien Levesque , Olivier Bénichou , Benjamin Rotenberg

Skin diseases affect millions of people worldwide, across all ethnicities. Increasing diagnosis accessibility requires fair and accurate segmentation and classification of dermatology images. However, the scarcity of annotated medical…

Computer Vision and Pattern Recognition · Computer Science 2023-07-24 Héctor Carrión , Narges Norouzi