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While the Gleason score is the most important prognostic marker for prostate cancer patients, it suffers from significant observer variability. Artificial Intelligence (AI) systems, based on deep learning, have proven to achieve…

Whole gland (WG) segmentation of the prostate plays a crucial role in detection, staging and treatment planning of prostate cancer (PCa). Despite promise shown by deep learning (DL) methods, they rely on the availability of a considerable…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Alvaro Fernandez-Quilez , Steinar Valle Larsen , Morten Goodwin , Thor Ole Gulsurd , Svein Reidar Kjosavik , Ketil Oppedal

A two-layer neural network model that systematically includes correlations among input variables to arbitrary order and is designed to implement Bayes inference has been adapted to classify breast cancer tumors as malignant or benign,…

Machine Learning · Computer Science 2019-12-17 Aditya Cowsik , John W. Clark

Multiple Instance Learning (MIL) has been widely applied in histopathology to classify Whole Slide Images (WSIs) with slide-level diagnoses. While the ground truth is established by expert pathologists, the slides can be difficult to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Marie Arrivat , Rémy Peyret , Elsa Angelini , Pietro Gori

Cell detection in histopathology images is of great value in clinical practice. \textit{Convolutional neural networks} (CNNs) have been applied to cell detection to improve the detection accuracy, where cell annotations are required for…

Computer Vision and Pattern Recognition · Computer Science 2021-07-01 Zipei Zhao , Fengqian Pang , Zhiwen Liu , Chuyang Ye

We present a fully automated, anatomically guided deep learning pipeline for prostate cancer (PCa) risk stratification using routine MRI. The pipeline integrates three key components: an nnU-Net module for segmenting the prostate gland and…

Prostate and zonal segmentation is a crucial step for clinical diagnosis of prostate cancer (PCa). Computer-aided diagnosis tools for prostate segmentation are based on the deep learning (DL) paradigm. However, deep neural networks are…

Advances in digital pathology and artificial intelligence (AI) offer promising opportunities for clinical decision support and enhancing diagnostic workflows. Previous studies already demonstrated AI's potential for automated Gleason…

Clinical cystoscopy, the current standard for bladder cancer diagnosis, suffers from significant reliance on physician expertise, leading to variability and subjectivity in diagnostic outcomes. There is an urgent need for objective,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jinliang Yu , Mingduo Xie , Yue Wang , Tianfan Fu , Xianglai Xu , Jiajun Wang

Leukemia is the 10th most frequently diagnosed cancer and one of the leading causes of cancer-related deaths worldwide. Realistic analysis of leukemia requires white blood cell (WBC) localization, classification, and morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Abdul Rehman , Talha Meraj , Aiman Mahmood Minhas , Ayisha Imran , Mohsen Ali , Waqas Sultani , Mubarak Shah

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monitoring. However, real-world WBC datasets present substantial appearance variations caused…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Luu Le , Hoang-Loc Cao , Ha-Hieu Pham , Thanh-Huy Nguyen , Ulas Bagci

This paper proposes a novel automatic classification framework for the recognition of five types of white blood cells. Segmenting complete white blood cells from blood smears images and extracting advantageous features from them remain…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Na Dong , Meng-die Zhai , Jian-fang Chang , Chun-ho Wu

Image segmentation is a fundamental problem in biomedical image analysis. Recent advances in deep learning have achieved promising results on many biomedical image segmentation benchmarks. However, due to large variations in biomedical…

Computer Vision and Pattern Recognition · Computer Science 2017-06-16 Lin Yang , Yizhe Zhang , Jianxu Chen , Siyuan Zhang , Danny Z. Chen

Nodule segmentation from breast ultrasound images is challenging yet essential for the diagnosis. Weakly-supervised segmentation (WSS) can help reduce time-consuming and cumbersome manual annotation. Unlike existing weakly-supervised…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Yuhao Huang , Xin Yang , Yuxin Zou , Chaoyu Chen , Jian Wang , Haoran Dou , Nishant Ravikumar , Alejandro F Frangi , Jianqiao Zhou , Dong Ni

Gastric cancer is the second leading cause of cancer-related deaths worldwide, and the major hurdle in biomedical image analysis is the determination of the cancer extent. This assignment has high clinical relevance and would generally…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 Yang Nan , Gianmarc Coppola , Qiaokang Liang , Kunglin Zou , Wei Sun , Dan Zhang , Yaonan Wang , Guanzhen Yu

Quality of deep convolutional neural network predictions strongly depends on the size of the training dataset and the quality of the annotations. Creating annotations, especially for 3D medical image segmentation, is time-consuming and…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Matin Hosseinzadeh , Anindo Saha , Joeran Bosma , Henkjan Huisman

Accurate segmentation of nodules in both 2D breast ultrasound (BUS) and 3D automated breast ultrasound (ABUS) is crucial for clinical diagnosis and treatment planning. Therefore, developing an automated system for nodule segmentation can…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Yuhao Huang , Ao Chang , Haoran Dou , Xing Tao , Xinrui Zhou , Yan Cao , Ruobing Huang , Alejandro F Frangi , Lingyun Bao , Xin Yang , Dong Ni

Mitosis count is an important biomarker for prognosis of various cancers. At present, pathologists typically perform manual counting on a few selected regions of interest in breast whole-slide-images (WSIs) of patient biopsies. This task is…

Computer Vision and Pattern Recognition · Computer Science 2018-08-01 Saad Ullah Akram , Talha Qaiser , Simon Graham , Juho Kannala , Janne Heikkilä , Nasir Rajpoot

Purpose: In this work, we present a collaboration to create a validation dataset of pathologist annotations for algorithms that process whole slide images (WSIs). We focus on data collection and evaluation of algorithm performance in the…

Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however,…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Xueying Shi , Qi Dou , Cheng Xue , Jing Qin , Hao Chen , Pheng-Ann Heng