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In conventional clinical in-vitro fertilization practices embryos are transferred either at the cleavage or blastocyst stages of development. Cleavage stage transfers, particularly, are beneficial for patients with relatively poor prognosis…

The developmental process of embryos follows a monotonic order. An embryo can progressively cleave from one cell to multiple cells and finally transform to morula and blastocyst. For time-lapse videos of embryos, most existing developmental…

Computer Vision and Pattern Recognition · Computer Science 2021-07-15 Stanislav Lukyanenko , Won-Dong Jang , Donglai Wei , Robbert Struyven , Yoon Kim , Brian Leahy , Helen Yang , Alexander Rush , Dalit Ben-Yosef , Daniel Needleman , Hanspeter Pfister

Automatic analyses and comparisons of different stages of embryonic development largely depend on a highly accurate spatiotemporal alignment of the investigated data sets. In this contribution, we assess multiple approaches for automatic…

Image and Video Processing · Electrical Eng. & Systems 2020-07-30 Manuel Traub , Johannes Stegmaier

The timing of cell divisions in early embryos during the In-Vitro Fertilization (IVF) process is a key predictor of embryo viability. However, observing cell divisions in Time-Lapse Monitoring (TLM) is a time-consuming process and highly…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Tien-Phat Nguyen , Trong-Thang Pham , Tri Nguyen , Hieu Le , Dung Nguyen , Hau Lam , Phong Nguyen , Jennifer Fowler , Minh-Triet Tran , Ngan Le

A major challenge in clinical In-Vitro Fertilization (IVF) is selecting the highest quality embryo to transfer to the patient in the hopes of achieving a pregnancy. Time-lapse microscopy provides clinicians with a wealth of information for…

In clinical In-Vitro Fertilization (IVF), identifying the most viable embryo for transfer is important to increasing the likelihood of a successful pregnancy. Traditionally, this process involves embryologists manually assessing embryos'…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Junsik Kim , Zhiyi Shi , Davin Jeong , Johannes Knittel , Helen Y. Yang , Yonghyun Song , Wanhua Li , Yicong Li , Dalit Ben-Yosef , Daniel Needleman , Hanspeter Pfister

Identification of fine-grained embryo developmental stages during In Vitro Fertilization (IVF) is crucial for assessing embryo viability. Although recent deep learning methods have achieved promising accuracy, existing discriminative models…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Yong Sun , Zhengjie Zhang , Junyu Shi , Zhiyuan Zhang , Lijiang Liu , Qiang Nie

Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI)…

Machine Learning · Computer Science 2022-04-06 Jørgen Berntsen , Jens Rimestad , Jacob Theilgaard Lassen , Dang Tran , Mikkel Fly Kragh

The process of fertilizing a human egg outside the body in order to help those suffering from infertility to conceive is known as in vitro fertilization (IVF). Despite being the most effective method of assisted reproductive technology…

Embryo selection is one of multiple crucial steps in in-vitro fertilization, commonly based on morphological assessment by clinical embryologists. Although artificial intelligence methods have demonstrated their potential to support embryo…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Nicklas Neu , Thomas Ebner , Jasmin Primus , Bernhard Schenkenfelder , Raphael Zefferer , Mathias Brunbauer , Florian Kromp

Infertility is a major global health issue, and while in-vitro fertilization has improved treatment outcomes, embryo selection remains a critical bottleneck. Time-lapse imaging enables continuous, non-invasive monitoring of embryo…

Artificial intelligence has recently shown promise in automated embryo selection for In-Vitro Fertilization (IVF). However, current approaches either address partial embryo evaluation lacking holistic quality assessment or target clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-06-06 Yong Sun , Yipeng Wang , Junyu Shi , Zhiyuan Zhang , Yanmei Xiao , Lei Zhu , Manxi Jiang , Qiang Nie

The selection of the optimal embryo for transfer is a critical yet challenging step in in vitro fertilization (IVF), primarily due to its reliance on the manual inspection of extensive time-lapse imaging data. A key obstacle in this process…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Zahra Asghari Varzaneh , Niclas Wölner-Hanssen , Reza Khoshkangini , Thomas Ebner , Magnus Johnsson

Recently, probabilistic predictive coding that directly models the conditional distribution of latent features across successive frames for temporal redundancy removal has yielded promising results. Existing methods using a single-scale…

Image and Video Processing · Electrical Eng. & Systems 2023-12-13 Ming Lu , Zhihao Duan , Fengqing Zhu , Zhan Ma

Infertility has a considerable impact on individuals' quality of life, affecting them socially and psychologically, with projections indicating a rise in the upcoming years. In vitro fertilization (IVF) emerges as one of the primary…

Automating embryo viability prediction for in vitro fertilization (IVF) is important but challenging due to the limited availability of labeled pregnancy outcome data, as only a small fraction of embryos are labeled after transfer.…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Zhiyi Shi , Junsik Kim , Helen Y. Yang , Yonghyun Song , Hyun-Jic Oh , Dalit Ben-Yosef , Daniel Needleman , Hanspeter Pfister

Automating human preimplantation embryo grading offers the potential for higher success rates with in vitro fertilization (IVF) by providing new quantitative and objective measures of embryo quality. Current IVF procedures typically use…

Image and Video Processing · Electrical Eng. & Systems 2020-08-21 Md Yousuf Harun , M Arifur Rahman , Joshua Mellinger , Willy Chang , Thomas Huang , Brienne Walker , Kristen Hori , Aaron T. Ohta

We present a novel method for identification of the boundary of embryonic cells (blastomeres) in Hoffman Modulation Contrast (HMC) microscopic images that are taken between day one to day three. Identification of boundaries of blastomeres…

Computer Vision and Pattern Recognition · Computer Science 2019-10-15 Shakiba Kheradmand , Parvaneh Saeedi , Jason Au , John Havelock

Gene expression levels carry information about signals that have functional significance for the organism. Using the gap gene network in the fruit fly embryo as an example, we show how this information can be decoded, building a dictionary…

Molecular Networks · Quantitative Biology 2024-01-23 Mariela D. Petkova , Gašper Tkačik , William Bialek , Eric F. Wieschaus , Thomas Gregor

Many segmentation tasks, such as medical image segmentation or future state prediction, are inherently ambiguous, meaning that multiple predictions are equally correct. Current methods typically rely on generative models to capture this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Sebastian Gerard , Josephine Sullivan
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