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We have established an RNA Mapping Database (RMDB) to enable a new generation of structural, thermodynamic, and kinetic studies from quantitative single-nucleotide-resolution RNA structure mapping (freely available at…

Biomolecules · Quantitative Biology 2011-10-04 Pablo Cordero , Julius Lucks , Rhiju Das

Here we present CaosDB, a Research Data Management System (RDMS) designed to ensure seamless integration of inhomogeneous data sources and repositories of legacy data. Its primary purpose is the management of data from biomedical sciences,…

In recent years, researchers have explored component-based synthesis, which aims to automatically construct programs that operate by composing calls to existing APIs. However, prior work has not considered efficient synthesis of methods…

Programming Languages · Computer Science 2021-04-09 Sankha Narayan Guria , Jeffrey S. Foster , David Van Horn

Advances in detectors and computational technologies provide new opportunities for applied research and the fundamental sciences. Concurrently, dramatic increases in the three Vs (Volume, Velocity, and Variety) of experimental data and the…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-15 Nikolay Malitsky , Aashish Chaudhary , Sebastien Jourdain , Matt Cowan , Patrick O'Leary , Marcus Hanwell , Kerstin Kleese Van Dam

The comparison of computer generated protein structural models is an important element of protein structure prediction. It has many uses including model quality evaluation, selection of the final models from a large set of candidates or…

Computational Engineering, Finance, and Science · Computer Science 2011-07-27 Paweł Widera , Natalio Krasnogor

DNA has been considered a promising medium for storing digital information. As an essential step in the DNA-based data storage workflow, coding algorithms are responsible to implement functions including bit-to-base transcoding, error…

Emerging Technologies · Computer Science 2023-03-31 Haoling Zhang , Zhaojun Lan , Wenwei Zhang , Xun Xu , Zhi Ping , Yiwei Zhang , Yue Shen

We develop a tool called PipeGen for efficient data transfer between database management systems (DBMSs). PipeGen targets data analytics workloads on shared-nothing engines. It supports scenarios where users seek to perform different parts…

Databases · Computer Science 2016-05-17 Brandon Haynes , Alvin Cheung , Magdalena Balazinska

This paper introduces an open source platform to support the rapid development of computer vision applications at scale. The platform puts the efficient data development at the center of the machine learning development process, integrates…

Artificial Intelligence · Computer Science 2021-12-01 Phoenix X. Huang , Wenze Hu , William Brendel , Manmohan Chandraker , Li-Jia Li , Xiaoyu Wang

We present "DistML.js", a library designed for training and inference of machine learning models within web browsers. Not only does DistML.js facilitate model training on local devices, but it also supports distributed learning through…

Machine Learning · Computer Science 2024-07-02 Masatoshi Hidaka , Tomohiro Hashimoto , Yuto Nishizawa , Tatsuya Harada

This report introduces PP-DocBee2, an advanced version of the PP-DocBee, designed to enhance multimodal document understanding. Built on a large multimodal model architecture, PP-DocBee2 addresses the limitations of its predecessor through…

Computer Vision and Pattern Recognition · Computer Science 2025-06-26 Kui Huang , Xinrong Chen , Wenyu Lv , Jincheng Liao , Guanzhong Wang , Yi Liu

Modern software systems rely heavily on Web APIs, yet creating meaningful and executable test scripts remains a largely manual, time-consuming, and error-prone task. In this paper, we present APITestGenie, a novel tool that leverages Large…

Software Engineering · Computer Science 2026-04-03 André Pereira , Bruno Lima , João Pascoal Faria

In the current context of Big Data, a multitude of new NoSQL solutions for storing, managing, and extracting information and patterns from semi-structured data have been proposed and implemented. These solutions were developed to relieve…

Computationally predicting protein-protein interactions (PPIs) is challenging due to the lack of integrated, multimodal protein representations. DPEB is a curated collection of 22,043 human proteins that integrates four embedding types:…

Getting acquainted with a large codebase can be a daunting task for software developers, both new and seasoned. The description of a codebase and its development should be the purpose of its documentation. However, software documentation,…

Software Engineering · Computer Science 2025-02-27 Adam Štěpánek , David Kuťák , Barbora Kozlíková , Jan Byška

Peptides offer great biomedical potential and serve as promising drug candidates. Currently, the majority of approved peptide drugs are directly derived from well-explored natural human peptides. It is quite necessary to utilize advanced…

Biomolecules · Quantitative Biology 2024-01-29 Yipin Lei , Xu Wang , Meng Fang , Han Li , Xiang Li , Jianyang Zeng

We introduce Dimple, a fully open-source API for probabilistic modeling. Dimple allows the user to specify probabilistic models in the form of graphical models, Bayesian networks, or factor graphs, and performs inference (by automatically…

Software Engineering · Computer Science 2012-12-14 Shawn Hershey , Jeff Bernstein , Bill Bradley , Andrew Schweitzer , Noah Stein , Theo Weber , Ben Vigoda

Bayesian Networks (BNs) are used in various fields for modeling, prediction, and decision making. pgmpy is a python package that provides a collection of algorithms and tools to work with BNs and related models. It implements algorithms for…

Machine Learning · Computer Science 2023-04-19 Ankur Ankan , Johannes Textor

When it comes to storing 3D city models in a database, the implementation of the CityGML data model can be quite demanding and often results in complicated schemas. As an example, 3DCityDB, a widely used solution, depends on a schema having…

Designing protein-binding proteins with high affinity is critical in biomedical research and biotechnology. Despite recent advancements targeting specific proteins, the ability to create high-affinity binders for arbitrary protein targets…

Machine Learning · Computer Science 2025-11-03 Zhenqiao Song , Tiaoxiao Li , Lei Li , Martin Renqiang Min