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The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

Drug overdose deaths, including those due to prescription opioids, represent a critical public health issue in the United States and worldwide. Artificial intelligence (AI) approaches have been developed and deployed to help prescribers…

Human-Computer Interaction · Computer Science 2025-02-18 Venkatesh Sivaraman , Yejun Kwak , Courtney Kuza , Qingnan Yang , Kayleigh Adamson , Katie Suda , Lu Tang , Walid Gellad , Adam Perer

The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in…

Quantitative Methods · Quantitative Biology 2019-05-03 Jen J. Gong , Abigail Z. Jacobs , Toby E. Stuart , Mathijs de Vaan

Machine learning algorithms can sometimes exacerbate health disparities based on ethnicity, gender, and other factors. There has been limited work at exploring potential biases within algorithms deployed on a small scale, and/or within…

Computational Engineering, Finance, and Science · Computer Science 2023-07-07 Abhay Goyal , Nimay Parekh , Lam Yin Cheung , Koustuv Saha , Frederick L Altice , Robin O'hanlon , Roger Ho Chun Man , Christian Poellabauer , Honoria Guarino , Pedro Mateu Gelabert , Navin Kumar

We describe two recently proposed machine learning approaches for discovering emerging trends in fatal accidental drug overdoses. The Gaussian Process Subset Scan enables early detection of emerging patterns in spatio-temporal data,…

Computers and Society · Computer Science 2017-10-09 Daniel B. Neill , William Herlands

Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family…

Machine Learning · Computer Science 2020-06-01 Ali Mert Ertugrul , Yu-Ru Lin , Tugba Taskaya-Temizel

Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved…

Biomolecules · Quantitative Biology 2023-01-13 Hongsong Feng , Rana Elladki , Jian Jiang , Guo-Wei Wei

In recent years, the US has experienced an opioid epidemic with an unprecedented number of drugs overdose deaths. Research finds such overdose deaths are linked to neighborhood-level traits, thus providing opportunity to identify effective…

Machine Learning · Computer Science 2021-12-07 Sachin Gavali , Chuming Chen , Julie Cowart , Xi Peng , Shanshan Ding , Cathy Wu , Tammy Anderson

Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued and compulsive use of opioids despite harmful consequences. The development of medications with improved efficacy and safety profiles for OUD…

Biomolecules · Quantitative Biology 2023-03-02 Hongsong Feng , Jian Jiang , Guo-Wei Wei

The opioid epidemic is a crisis that has plagued the United States (US) for decades. One central issue is inequitable access to treatment for opioid use disorder (OUD), which puts certain populations at a higher risk of opioid overdose. We…

Physics and Society · Physics 2024-03-14 Joyce Luo , Bartolomeo Stellato

Drug overdose deaths, including from opioids, remain a significant public health threat to the United States (US). To abate the harms of opioid misuse, understanding its prevalence at the local level is crucial for stakeholders in…

Applications · Statistics 2026-01-09 Zixuan Feng , Qiushi Chen , Paul Griffin , Le Bao

Opioid addiction has become a global epidemic and a national health crisis in recent years, with the number of opioid overdose fatalities steadily increasing since the 1990s. In contrast to the dynamics of a typical illicit drug or disease…

Populations and Evolution · Quantitative Biology 2019-05-03 Nicholas A. Battista , Leigh B. Pearcy , W. Christopher Strickland

We present efforts in the fields of machine learning and time series forecasting to accurately predict counts of future suspected opioid overdoses recorded by Emergency Medical Services (EMS) in the state of Kentucky. Forecasts help…

This paper introduces the OPIAID algorithm, a novel approach for predicting and recommending personalized opioid dosages for individual patients. The algorithm optimizes pain management while minimizing opioid related adverse events (ORADE)…

Mental disorders impact the lives of millions of people globally, not only impeding their day-to-day lives but also markedly reducing life expectancy. This paper addresses the persistent challenge of predicting mortality in patients with…

Machine Learning · Computer Science 2023-10-19 Sean Kim , Samuel Kim

Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative…

Machine Learning · Computer Science 2022-05-18 Yuming Sun , Jian Kang , Chad Brummett , Yi Li

Drug overdose remains a critical global health issue, often driven by misuse of opioids, painkillers, and psychiatric medications. Traditional research methods face limitations, whereas social media offers real-time insights into…

Computation and Language · Computer Science 2025-07-16 Muhammad Ahmad , Fida Ullah , Muhammad Usman , Umyh Habiba , ldar Batyrshin , Grigori Sidorov

Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of thousands of premature deaths in the United States yearly.…

Quantitative Methods · Quantitative Biology 2024-03-27 Sybille Légitime , Kaustubh Prabhu , Devin McConnell , Bing Wang , Dipak K. Dey , Derek Aguiar

Opioid overdose has emerged as a full blown epidemic in the United States. In the last few years, there has been an alarming increase in Opioid related deaths, resulting in the loss of 63,600 lives in 2016 alone. The epidemic which is…

Computers and Society · Computer Science 2018-05-16 Kaustav Basu , Sandipan Choudhuri , Arunabha Sen , Aniket Majumdar

Motivation: Opioid use disorder (OUD) often arises after prescription opioid exposure and follows transitions among onset, remission, and relapse. Linked EHR-survey resources such as the All of Us Research Program enable stage-specific risk…

Quantitative Methods · Quantitative Biology 2026-01-23 Mengman Wei , Stanislav Listopad , Qian Peng
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