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Machine learning in drug discovery has been focused on virtual screening of molecular libraries using discriminative models. Generative models are an entirely different approach that learn to represent and optimize molecules in a continuous…

Quantitative Methods · Quantitative Biology 2020-11-17 Matthew Ragoza , Tomohide Masuda , David Ryan Koes

Deep Neural Networks (DNNs) suffer from a rapid decrease in performance when trained on a sequence of tasks where only data of the most recent task is available. This phenomenon, known as catastrophic forgetting, prevents DNNs from…

Machine Learning · Computer Science 2021-04-22 Felix Wiewel , Bin Yang

Continual Graph Learning(CGL)focuses on acquiring new knowledge while retaining previously learned information, essential for real-world graph applications. Current methods grapple with two main issues:1) The Stability-Plasticity Dilemma:…

Machine Learning · Computer Science 2025-09-03 Jingtao Liu , Xinming Zhang

Diffusion models have achieved remarkable success in generating high-quality images thanks to their novel training procedures applied to unprecedented amounts of data. However, training a diffusion model from scratch is computationally…

Machine Learning · Computer Science 2023-03-28 Michał Zając , Kamil Deja , Anna Kuzina , Jakub M. Tomczak , Tomasz Trzciński , Florian Shkurti , Piotr Miłoś

Humans accumulate knowledge in a lifelong fashion. Modern deep neural networks, on the other hand, are susceptible to catastrophic forgetting: when adapted to perform new tasks, they often fail to preserve their performance on previously…

Computer Vision and Pattern Recognition · Computer Science 2021-04-27 Mengyao Zhai , Lei Chen , Jiawei He , Megha Nawhal , Frederick Tung , Greg Mori

In medical imaging, technical progress or changes in diagnostic procedures lead to a continuous change in image appearance. Scanner manufacturer, reconstruction kernel, dose, other protocol specific settings or administering of contrast…

Machine Learning · Computer Science 2020-07-08 Johannes Hofmanninger , Matthias Perkonigg , James A. Brink , Oleg Pianykh , Christian Herold , Georg Langs

Continual learning is inherently a constrained learning problem. The goal is to learn a predictor under a no-forgetting requirement. Although several prior studies formulate it as such, they do not solve the constrained problem explicitly.…

Machine Learning · Computer Science 2024-06-03 Juan Elenter , Navid NaderiAlizadeh , Tara Javidi , Alejandro Ribeiro

Continual learning requires balancing plasticity and stability while mitigating catastrophic forgetting. Inspired by human dreaming as a mechanism for internal simulation and knowledge restructuring, we introduce Dream2Learn (D2L), a…

Deep neural networks (DNNs) have recently achieved a great success in computer vision and several related fields. Despite such progress, current neural architectures still suffer from catastrophic interference (a.k.a. forgetting) which…

Computer Vision and Pattern Recognition · Computer Science 2021-11-23 Hichem Sahbi , Haoming Zhan

We present a continual learning approach for generative adversarial networks (GANs), by designing and leveraging parameter-efficient feature map transformations. Our approach is based on learning a set of global and task-specific…

Machine Learning · Computer Science 2021-08-02 Sakshi Varshney , Vinay Kumar Verma , Srijith P K , Lawrence Carin , Piyush Rai

We propose Deep Companion Learning (DCL), a novel training method for Deep Neural Networks (DNNs) that enhances generalization by penalizing inconsistent model predictions compared to its historical performance. To achieve this, we train a…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 Ruizhao Zhu , Venkatesh Saligrama

One of the objectives of continual learning is to prevent catastrophic forgetting in learning multiple tasks sequentially, and the existing solutions have been driven by the conceptualization of the plasticity-stability dilemma. However,…

Machine Learning · Computer Science 2024-04-16 Seungyub Han , Yeongmo Kim , Taehyun Cho , Jungwoo Lee

In this paper, we propose a continual learning (CL) technique that is beneficial to sequential task learners by improving their retained accuracy and reducing catastrophic forgetting. The principal target of our approach is the automatic…

Machine Learning · Computer Science 2021-01-19 Ammar Shaker , Shujian Yu , Francesco Alesiani

Continual learning on graph data has recently attracted paramount attention for its aim to resolve the catastrophic forgetting problem on existing tasks while adapting the sequentially updated model to newly emerged graph tasks. While there…

Machine Learning · Computer Science 2024-02-20 Xikun Zhang , Dongjin Song , Dacheng Tao

Cognitive functions in current artificial intelligence networks are tied to the exponential increase in network scale, whereas the human brain can continuously learn hundreds of cognitive functions with remarkably low energy consumption.…

Artificial Intelligence · Computer Science 2025-04-09 Bing Han , Feifei Zhao , Yinqian Sun , Wenxuan Pan , Yi Zeng

A common challenge in continual learning (CL) is catastrophic forgetting, where the performance on old tasks drops after new, additional tasks are learned. In this paper, we propose a novel framework called ReCL to slow down forgetting in…

Machine Learning · Computer Science 2025-03-04 Pascal Janetzky , Tobias Schlagenhauf , Stefan Feuerriegel

Continual learning refers to the capability of a machine learning model to learn and adapt to new information, without compromising its performance on previously learned tasks. Although several studies have investigated continual learning…

Information Retrieval · Computer Science 2024-06-21 Jingrui Hou , Georgina Cosma , Axel Finke

Deep generative models (DGMs) are effective on learning multilayered representations of complex data and performing inference of input data by exploring the generative ability. However, little work has been done on examining or empowering…

Machine Learning · Computer Science 2015-12-16 Chongxuan Li , Jun Zhu , Tianlin Shi , Bo Zhang

Contemporary deep neural networks offer state-of-the-art results when applied to visual reasoning, e.g., in the context of 3D point cloud data. Point clouds are important datatype for precise modeling of three-dimensional environments, but…

Machine Learning · Computer Science 2022-05-23 Maciej Zamorski , Michał Stypułkowski , Konrad Karanowski , Tomasz Trzciński , Maciej Zięba

Reading is foundational for educational, employment, and economic outcomes, but a persistent proportion of students globally struggle to develop adequate reading skills. Some countries promote digital tools to support reading development,…

Applications · Statistics 2026-03-19 Yawen Ma , Anastasia Ushakova , Kate Cain , Gabriel Wallin
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