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We consider the problem of parameter estimation in a high-dimensional generalized linear model. Spectral methods obtained via the principal eigenvector of a suitable data-dependent matrix provide a simple yet surprisingly effective…

Statistics Theory · Mathematics 2025-07-11 Yihan Zhang , Hong Chang Ji , Ramji Venkataramanan , Marco Mondelli

In the transfer learning paradigm models learn useful representations (or features) during a data-rich pretraining stage, and then use the pretrained representation to improve model performance on data-scarce downstream tasks. In this work,…

Machine Learning · Statistics 2025-04-14 Yufan Li , Subhabrata Sen , Ben Adlam

Computing pseudospectra of non-normal matrices is essential for understanding the stability and transient behavior of dynamical systems. Such analysis is critical in applications including fluid dynamics, control systems, and differential…

Numerical Analysis · Mathematics 2026-05-07 Amit Punia , Rakesh Kumar , Madan Lal

Histopathology, the current gold standard for cancer diagnosis, involves the manual examination of tissue samples after chemical staining, a time-consuming process requiring expert analysis. Raman spectroscopy is an alternative, stain-free…

Accurate prediction and identification of variables associated with outcomes or disease states are critical for advancing diagnosis, prognosis, and precision medicine in biomedical research. Regularized regression techniques, such as lasso,…

Applications · Statistics 2025-04-14 Xiaoru Dong , Apoorva Goyal , Muxuan Liang , Maigan A. Brusko , Todd M. Brusko , Rhonda Bacher

Scientific machine learning increasingly uses spectral methods to understand physical systems. Current spectral learning approaches provide only point estimates without uncertainty quantification, limiting their use in safety-critical…

Machine Learning · Computer Science 2025-09-17 Mohammad Nooraiepour

Currently, a large number of stored tissue samples are unavailable for spectroscopic study without the time consuming and destructive process of paraffin removal. Instead, a structurally sensitive technique, sum frequency generation, and a…

Medical Physics · Physics 2023-10-03 Bryan Semon , Michael Jaffe , Haifeng Wang , Lauren Priddy , Gombojav Ariunbold

Raman spectroscopy is an appealing technique that probes molecular vibrations in a wide variety of materials with virtually no sample preparation. However, accurate and reliable Raman measurements are still a challenge and require more…

Optics · Physics 2020-02-14 Hugo Kerdoncuff , Mikael Lassen , Jan C. Petersen

Randomization is a common technique used in clinical trials to eliminate potential bias and confounders in a patient population. Equal allocation to treatment groups is the standard due to its optimal efficiency in many cases. However, in…

Applications · Statistics 2020-04-09 Thevaa Chandereng , Xiaodan Wei , Rick Chappell

In today's modern era of Big data, computationally efficient and scalable methods are needed to support timely insights and informed decision making. One such method is sub-sampling, where a subset of the Big data is analysed and used as…

Methodology · Statistics 2022-09-07 Amalan Mahendran , Helen Thompson , James M. McGree

Sensor monitoring networks and advances in big data analytics have guided the reliability engineering landscape to a new era of big machinery data. Low-cost sensors, along with the evolution of the internet of things and industry 4.0, have…

Machine Learning · Statistics 2021-10-11 Sergio Cofre-Martel , Enrique Lopez Droguett , Mohammad Modarres

Over the past several decades, many different types of computational imaging approaches have been proposed for improving MRI. In this paper, we provide an overview of methods that assume that MRI Fourier data is linearly predictable. Linear…

Signal Processing · Electrical Eng. & Systems 2020-02-19 Justin P. Haldar , Kawin Setsompop

The early detection of cancer is a challenging problem in medicine. The blood sera of cancer patients are enriched with heterogeneous secretory lipid bound extracellular vesicles (EVs), which present a complex repertoire of information and…

Other Quantitative Biology · Quantitative Biology 2022-02-15 Abicumaran Uthamacumaran , Samir Elouatik , Mohamed Abdouh , Michael Berteau-Rainville , Zu-hua Gao , Goffredo Arena

Realisation of experiments even on small and medium-scale quantum computers requires an optimisation of several parameters to achieve high-fidelity operations. As the size of the quantum register increases, the characterisation of quantum…

Quantum Physics · Physics 2020-08-11 F. Martínez-García , D. Vodola , M. Müller

In the era of Big Data, prompt analysis and processing of data sets is critical. Meanwhile, statistical methods provide key tools and techniques to extract valuable insights and knowledge from complex data sets. This paper creatively…

Signal Processing · Electrical Eng. & Systems 2024-05-27 Linlin Wang , Mingxue Quan , Wei Wang , Dezhao Wang , Shanwen Wang

Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 William Consagra , Lipeng Ning , Yogesh Rathi

Confocal Raman microscopy, a highly specific and label-free technique for the microscale study of thick samples, often presents difficulties due to weak Raman signals. Inhomogeneous samples introduce wavefront aberrations that further…

Web log data is usually diverse and voluminous. This data must be assembled into a consistent, integrated and comprehensive view, in order to be used for pattern discovery. Without properly cleaning, transforming and structuring the data…

Databases · Computer Science 2011-04-13 C. Ramya , K S Shreedhara , G Kavitha

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human…

Emerging Technologies · Computer Science 2026-03-12 Abdollah Rezagholi , Sergi Abadal , Filip Lemic , Eduard Alarcon , Ethungshan Shitiri

Variable selection has played a critical role in modern statistical learning and scientific discoveries. Numerous regularization and Bayesian variable selection methods have been developed in the past two decades for variable selection, but…

Methodology · Statistics 2024-03-04 Travis Canida , Hongjie Ke , Shuo Chen , Zhenayo Ye , Tianzhou Ma