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Stochastic, spatial reaction-diffusion simulations have been widely used in systems biology and computational neuroscience. However, the increasing scale and complexity of simulated models and morphologies have exceeded the capacity of any…

Quantitative Methods · Quantitative Biology 2016-10-10 Weiliang Chen , Erik De Schutter

Stochastic equations play an important role in computational science, due to their ability to treat a wide variety of complex statistical problems. However, current algorithms are strongly limited by their sampling variance, which scales…

Numerical Analysis · Mathematics 2017-01-04 Bogdan Opanchuk , Simon Kiesewetter , Peter D. Drummond

Sparsity-based methods are widely used in machine learning, statistics, and signal processing. There is now a rich class of structured sparsity approaches that expand the modeling power of the sparsity paradigm and incorporate constraints…

Data Structures and Algorithms · Computer Science 2017-12-22 Aleksander Mądry , Slobodan Mitrović , Ludwig Schmidt

Building efficient, accurate and generalizable reduced order models of developed turbulence remains a major challenge. This manuscript approaches this problem by developing a hierarchy of parameterized reduced Lagrangian models for…

Massively parallel computer architectures create new opportunities for the performance of long-timescale molecular dynamics (MD) simulations. Here, we introduce the path-accelerated molecular dynamics (PAMD) method that takes advantage of…

Computational Physics · Physics 2021-01-11 Jorge L. Rosa-Raíces , Bin Zhang , Thomas F. Miller

Smoothed particle hydrodynamics (SPH) is omnipresent in modern engineering and scientific disciplines. SPH is a class of Lagrangian schemes that discretize fluid dynamics via finite material points that are tracked through the evolving…

The data-driven discovery of long-time macroscopic dynamics and thermodynamics of dissipative systems with particle fidelity is hampered by significant obstacles. These include the strong time-scale limitations inherent to particle…

Machine Learning · Computer Science 2025-05-21 Zequn He , Celia Reina

We introduce a novel and efficient algorithm called the stochastic approximate gradient descent (SAGD), as an alternative to the stochastic gradient descent for cases where unbiased stochastic gradients cannot be trivially obtained.…

Machine Learning · Computer Science 2020-02-14 Yixuan Qiu , Xiao Wang

As an important Markov Chain Monte Carlo (MCMC) method, stochastic gradient Langevin dynamics (SGLD) algorithm has achieved great success in Bayesian learning and posterior sampling. However, SGLD typically suffers from slow convergence…

Machine Learning · Computer Science 2019-11-05 Bao Wang , Difan Zou , Quanquan Gu , Stanley Osher

Simulating the flow of different fluids can be a highly computational intensive process, which requires large amounts of resources. Recently there has been a lot of research effort directed towards GPU processing, which can greatly increase…

Computational Engineering, Finance, and Science · Computer Science 2019-07-17 Adrian Coman , Elena Apostol , Catalin Leordeanu , Emil Slusanschi

Engineering simulations are usually based on complex, grid-based, or mesh-free methods for solving partial differential equations. The results of these methods cover large fields of physical quantities at very many discrete spatial…

Fluid Dynamics · Physics 2025-08-08 Eduardo Di Costanzo , Niklas Kühl , Jean-Christophe Marongiu , Thomas Rung

Stochastic gradients have been widely integrated into Langevin-based methods to improve their scalability and efficiency in solving large-scale sampling problems. However, the proximal sampler, which exhibits much faster convergence than…

Machine Learning · Statistics 2024-05-28 Xunpeng Huang , Difan Zou , Yi-An Ma , Hanze Dong , Tong Zhang

In recent years, several particle-based stochastic simulation algorithms (PSSA) have been developed to study the spatially resolved dynamics of biochemical networks at a molecular scale. A challenge all these approaches have to address is…

Quantitative Methods · Quantitative Biology 2011-07-04 Thorsten Prüstel , Martin Meier-Schellersheim

Microswimmers play an important role in shaping the world around us. The squirmer is a simple model for microswimmer whose cilia oscillations on its spherical surface induce an effective slip velocity to propel itself. The rapid development…

Fluid Dynamics · Physics 2024-11-22 Xinwei Cai , Kuiliang Wang , Gaojin Li , Xin Bian

Owing to the diverse scales and varying distributions of sparse matrices arising from practical problems, a multitude of choices are present in the design and implementation of sparse matrix-vector multiplication (SpMV). Researchers have…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-11-18 Jianhua Gao , Bingjie Liu , Yizhuo Wang , Weixing Ji , Hua Huang

We consider the problem of high-dimensional filtering of state-space models (SSMs) at discrete times. This problem is particularly challenging as analytical solutions are typically not available and many numerical approximation methods can…

Computation · Statistics 2022-01-13 Hamza Ruzayqat , Aimad Er-Raiy , Alexandros Beskos , Dan Crisan , Ajay Jasra , Nikolas Kantas

Stokesian Dynamics (SD) is a powerful computational framework for simulating the motion of particles in a viscous Newtonian fluid under Stokes-flow conditions. Traditional SD implementations can be computationally expensive as they rely on…

Fluid Dynamics · Physics 2025-07-02 Kim William Torre , Raoul D. Schram , Joost de Graaf

We present a novel approach to investigate the long-time stochastic dynamics of multi-dimensional classical systems, in contact with a heat-bath. When the potential energy landscape is rugged, the kinetics displays a decoupling of short and…

Soft Condensed Matter · Physics 2013-05-29 O. Corradini , P. Faccioli , H. Orland

Water demand is a highly important variable for operational control and decision making. Hence, the development of accurate forecasts is a valuable field of research to further improve the efficiency of water utilities. Focusing on…

Applications · Statistics 2020-05-12 Jens Kley-Holsteg , Florian Ziel

A novel stochastic fluid model is proposed with non-ideal structure factor consistent with compressibility, and adjustable transport coefficients. This Stochastic Hard Sphere Dynamics (SHSD) algorithm is a modification of the Direct…

Statistical Mechanics · Physics 2009-11-13 Aleksandar Donev , Berni J. Alder , Alejandro L. Garcia