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This study investigates the applicability of 3D dose predictions from a model trained on one modality to a cross-modality automated planning workflow. Additionally, we explore the impact of integrating a multi-criteria optimizer on adapting…

Medical Physics · Physics 2024-02-26 Gregory Szalkowski , Xuanang Xu , Shiva Das , Pew-Thian Yap , Jun Lian

The Multi-Objective Real-Valued Gene-pool Optimal Mixing Evolutionary Algorithm (MO-RV-GOMEA) has been proven effective and efficient in solving real-world problems. A prime example is optimizing treatment plans for prostate cancer…

Neural and Evolutionary Computing · Computer Science 2022-03-18 Leah R. M. Dickhoff , Ellen M. Kerkhof , Heloisa H. Deuzeman , Carien L. Creutzberg , Tanja Alderliesten , Peter A. N. Bosman

Quantitative MRI (qMRI) offers tissue-specific biomarkers that can be tracked over time or compared across populations; however, its adoption in clinical research is hindered by significant computational demands of parameter estimation.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Kwok-Shing Chan , Hansol Lee , Yixin Ma , Berkin Bilgic , Susie Y. Huang , Hong-Hsi Lee , José P. Marques

Multimodal instruction tuning is often compute-inefficient because training budgets are spread across large mixed image-video pools whose utility is highly uneven. We present Goal-Driven Data Optimization (GDO), a framework that computes…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Rujie Wu , Haozhe Zhao , Hai Ci , Yizhou Wang

Contemporary macro energy systems modelling is characterized by the need to represent strategic and operational decisions with high temporal and spatial resolution and represent discrete investment and retirement decisions. This drive…

Optimization and Control · Mathematics 2025-10-31 Michael Lau , Filippo Pecci , Jesse D. Jenkins

Purpose: To develop a novel aperture-based algorithm for volumetric modulated arc therapy (VMAT) treatment plan optimization with high quality and high efficiency. Methods: The VMAT optimization problem is formulated as a large-scale convex…

Medical Physics · Physics 2015-05-19 Chunhua Men , H. Edwin Romeijn , Xun Jia , Steve B. Jiang

3D computer-assisted corrective osteotomy has become the state-of-the-art for surgical treatment of complex bone deformities. Despite available technologies, the automatic generation of clinically acceptable, ready-to-use preoperative…

A novel Gibbs Markov random field for spatial data on Cartesian grids based on the modified planar rotator (MPR) model of statistical physics has been recently introduced for efficient and automatic interpolation of big data sets, such as…

Computational Physics · Physics 2019-10-21 Milan Žukovič , Michal Borovský , Matúš Lach , Dionissios T. Hristopulos

Around half of all cancer patients, world-wide, will receive some form of radiotherapy (RT) as part of their treatment. And yet, despite the rapid advance of high-throughput screening to identify successful chemotherapy drug candidates,…

Medical Physics · Physics 2023-04-07 Wojciech Ozimek , Rafał Banaś , Paweł Gora , Simon D. Angus , Monika J. Piotrowska

COVID-19 has shown the importance of having a fast response against pandemics. Finding a novel drug is a very long and complex procedure, and it is possible to accelerate the preliminary phases by using computer simulations. In particular,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-13 Emanuele Vitali , Federico Ficarelli , Mauro Bisson , Davide Gadioli , Massimiliano Fatica , Andrea R. Beccari , Gianluca Palermo

GPCG is an algorithm within the Toolkit for Advanced Optimization (TAO) for solving bound constrained, convex quadratic problems. Originally developed by More' and Toraldo, this algorithm was designed for large-scale problems but had been…

Mathematical Software · Computer Science 2007-05-23 Steven J. Benson , Lois Curfman McInnes , Jorge J. Moré

Inverse optimization (IO) algorithms are used in GYN HDR brachytherapy planning, with user parameter settings embedded in commercial TPS. To examine the dosimetric influence of hidden input parameters in three IO algorithms-IPSA, HIPO, and…

Medical Physics · Physics 2026-01-09 YeongHyeon Park , Shiqin Su , Sarath Vijayan , Zhiqian Henry Yu , Mandy Cunningham , Yusung Kim

In recent years, the Hamiltonian Monte Carlo (HMC) algorithm has been found to work more efficiently compared to other popular Markov Chain Monte Carlo (MCMC) methods (such as random walk Metropolis-Hastings) in generating samples from a…

Computation · Statistics 2014-02-18 Andrew L. Beam , Sujit K. Ghosh , Jon Doyle

Computing proposed exact $G$-optimal designs for response surface models is a difficult computation that has received incremental improvements via algorithm development in the last two-decades. These optimal designs have not been considered…

Computation · Statistics 2022-06-15 Stephen J. Walsh , John J. Borkowski

Recently, graphics processors (GPUs) have been increasingly leveraged in a variety of scientific computing applications. However, architectural differences between CPUs and GPUs necessitate the development of algorithms that take advantage…

Mathematical Software · Computer Science 2015-01-05 Jonathan Wong , Ellen Kuhl , Eric Darve

We present a set of rules to guide the design of GPU algorithms. These rules are grounded on the principle of reducing waste in GPU utility to achieve good speed up. In accordance to these rules, we propose GPU algorithms for 2D…

Graphics · Computer Science 2020-07-02 Zhenghai Chen , Tiow-Seng Tan , Hong-Yang Ong

Due to the large combinatorial problem, current beam orientation optimization algorithms for radiotherapy, such as column generation (CG), are typically heuristic or greedy in nature, leading to suboptimal solutions. We propose a…

Medical Physics · Physics 2020-04-15 Azar Sadeghnejad-Barkousaraie , Gyanendra Bohara , Steve Jiang , Dan Nguyen

3D Gaussian splatting (3DGS) is a transformative technique with profound implications on novel view synthesis and real-time rendering. Given its importance, there have been many attempts to improve its performance. However, with the…

Hardware Architecture · Computer Science 2025-10-14 Yi Hu , Huiyang Zhou

To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Radiotherapy inverse planning often requires planners to modify parameters in the treatment planning system's objective function to produce clinically acceptable plans. Due to the manual steps in this process, plan quality can vary…

Medical Physics · Physics 2022-05-11 Kelsey Maass , Aleksandr Aravkin , Minsun Kim