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Extraordinarily large but short electric field pulses are reported by many experiments to cause bipolar cancellation (BPC). This unusual cell response occurs if a first pulse is followed by a second pulse with opposite polarity. Possibly…

Subcellular Processes · Quantitative Biology 2018-07-04 Thiruvallur R. Gowrishankar , Julie V. Stern , Kyle C. Smith , James C. Weaver

Standard model of electropration (EP) has long emphasized a single pore lifetime to explain post-pulse transport across cell membranes. However, pore lifetimes estimated from molecular dynamics (MD) models and and those measured from…

Biological Physics · Physics 2017-10-11 Thiruvallur R. Gowrishankar , Julie V. Stern , James C. Weaver

An anomalous back discharge movement phenomenon is induced by a set of dielectric barrier corona discharges (DBCD) at unipolar half-sine voltage waveforms, where the back discharge has a time delay that relates to the applied voltage level.…

Applied Physics · Physics 2026-03-05 Gan Fu

A molecular dynamics (MD) simulation is used to quantitatively analyze the induced membrane potential for an applied external field varied between 0.4 V/nm to 2.0 V/nm. The change in the electrostatic potential in the DPPC is directly…

Biological Physics · Physics 2023-11-02 Shadeeb Hossain

We apply particle based kinetic simulations to explore the characteristics of a low-pressure gas discharge driven by high-voltage ( $\sim$ kV) pulses with alternating polarity, with a duty cycle of $\approx$ 1% and a repetition rate of 5…

We review some of the basic concepts and the possible pore structures associated with electroporation (EP) for times after electrical pulsing. We purposefully give only a short description of pore creation and subsequent evolution of pore…

Biological Physics · Physics 2017-08-25 James C. Weaver , P. Thomas Vernier

The excitation of many cells and tissues is associated with cell mechanical changes. The evidence presented herein corroborates that single cells deform during an action potential (AP). It is demonstrated that excitation of plant cells…

Biological Physics · Physics 2018-07-17 Christian Fillafer , Matan Mussel , Julia Muchowski , Matthias F. Schneider

We describe a concept that has the potential to change how we think about the underlying mechanisms of cell membrane electroporation (EP). Prior experimental, theoretical and modeling have emphasized a single pore lifetime as adequate for…

Biological Physics · Physics 2017-08-28 Julie V. Stern , Thiruvallur R. Gowrishankar , Kyle C. Smith , James C. Weaver

The contact process with diffusion (PCPD) defined by the binary reactions 2 B -> 3 B, 2 B -> 0 and diffusive particle spreading exhibits an unusual active to absorbing phase transition whose universality class has long been disputed.…

Statistical Mechanics · Physics 2020-10-28 Shengfeng Deng , Wei Li , Uwe C. Täuber

In this work we developed a method for simulating polar species in the dissipative particle dynamics (DPD) method. The main idea behind the method is to treat each bead as a dumb-bell, i.e. two sub-beads (the sub-beads can bear charges)…

Computational Physics · Physics 2020-04-24 Alexey A. Gavrilov

The physical approach of a small particle (virus, medical drug) to the cell membrane represents the crucial first step before active internalization and is governed by thermal diffusion. Using a fully analytical theory we show that the…

Fluid Dynamics · Physics 2016-02-17 Abdallah Daddi-Moussa-Ider , Achim Guckenberger , Stephan Gekle

An isothermal porous-electrode model of a discharging lead-acid battery is presented, which includes an extension of concentrated-solution theory that accounts for excluded-volume effects, local pressure variation, and a detailed…

Chemical Physics · Physics 2020-06-05 Valentin Sulzer , S. Jon Chapman , Colin P. Please , David A. Howey , Charles W. Monroe

The thermodynamic (TD) properties of biological membranes play a central role for living systems. It has been suggested, for instance, that nonlinear pulses such as action potentials (APs) can only exist if the membrane state is in vicinity…

Biological Physics · Physics 2020-07-16 Christian Fillafer , Anne Paeger , Matthias F. Schneider

A conventional explanation of the dipole anisotropy of the cosmic microwave background (CMB) radiation is in terms of the Doppler effect: our galaxy is moving with respect to CMB frame with $ \sim 600 ~ km ~ s^{-1} $. However, as the deep…

Astrophysics · Physics 2007-05-23 M. Jaroszynski , B. Paczynski

The transport equation of active motion is generalised to consider time-fractional dynamics for describing the anomalous diffusion of self-propelled particles observed in many different systems. In the present study, we consider an…

Statistical Mechanics · Physics 2023-10-27 Francisco J. Sevilla , Guillermo Chacón-Acosta , Trifce Sandev

Biomembranes, which are mainly composed of neutral and charged lipids, exhibit a large variety of functional structures and dynamics. Here, we report a coarse-grained molecular dynamics (MD) simulation of the phase separation and…

Soft Condensed Matter · Physics 2016-11-07 Hiroaki Ito , Yuji Higuchi , Naofumi Shimokawa

Time-dependent multiphysics interactions that drive the energy transfer in electromechanical systems are poorly understood. We probe dielectric barrier discharge (DBD) with an external DC-augmented (DCA) field to reveal new mechanistic…

Plasma Physics · Physics 2024-03-28 Anthony Tang , Alberto Aliseda , Alexander Mamishev , Igor Novosselov

In this tutorial we provide a short review of attosecond pulse characterization techniques and a pedagogical account of a recently proposed method called Pulse Analysis by Delayed Absorption (PANDA) [Pabst and Dahlstr\"om, Phys. Rev. A, 94,…

Quantum Physics · Physics 2018-11-26 Jan Marcus Dahlström , Stefan Pabst , Eva Lindroth

Cued and un-cued cell polarization is a fundamental mechanism in cell biology. As an alternative to the classical Turing bifurcation, it has been proposed that the cell polarity might onset by means of the well-known phenomenon of…

Molecular Networks · Quantitative Biology 2015-06-12 Sebastiano de Franciscis , Alberto d'Onofrio

We present a deformation-dependent propulsion phenomenon for soft particles such as cells in microchannels. It is based on a broken time reversal symmetry generated by a fast forward and slow backward motion of a fluid which does not…

Soft Condensed Matter · Physics 2022-02-22 Winfried Schmidt , Andre Förtsch , Matthias Laumann , Walter Zimmermann
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