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Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired…

Systems and Control · Computer Science 2018-07-16 Armin Küper , Robert Dürr , Steffen Waldherr

The machine learning community has recently devoted much attention to the problem of inferring causal relationships from statistical data. Most of this work has focused on uncovering connections among scalar random variables. We generalize…

Machine Learning · Statistics 2012-07-10 Doris Entner , Patrik O. Hoyer

If the assumed model does not accurately capture the underlying structure of the data, a statistical method is likely to yield sub-optimal results, and so model selection is crucial in order to conduct any statistical analysis. However, in…

Methodology · Statistics 2023-06-21 Vasilis Chasiotis , Dimitris Karlis

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

The GOR program for predicting protein secondary structure is extended to include triple correlation. A score system for a residue pair to be at certain conformation state is derived from the conditional weight matrix describing amino acid…

Biological Physics · Physics 2007-05-23 Xin Liu , Li-mei Zhang , Wei-Mou Zheng

Preferential attachment is an appealing mechanism for modeling power-law behavior of the degree distributions in directed social networks. In this paper, we consider methods for fitting a 5-parameter linear preferential model to network…

Methodology · Statistics 2017-08-29 Phyllis Wan , Tiandong Wang , Richard A. Davis , Sidney I. Resnick

This paper proposes using a method named Double Score Matching (DSM) to do mass-imputation and presents an application to make inferences with a nonprobability sample. DSM is a $k$-Nearest Neighbors algorithm that uses two balance scores…

Methodology · Statistics 2021-10-19 Ali Furkan Kalay

The quality of the inferences we make from pathogen sequence data is determined by the number and composition of pathogen sequences that make up the sample used to drive that inference. However, there remains limited guidance on how to best…

Populations and Evolution · Quantitative Biology 2023-06-13 Lucy D'Agostino McGowan , Shirlee Wohl , Justin Lessler

Likelihood-free methods perform parameter inference in stochastic simulator models where evaluating the likelihood is intractable but sampling synthetic data is possible. One class of methods for this likelihood-free problem uses a…

Machine Learning · Statistics 2020-12-21 Conor Durkan , Iain Murray , George Papamakarios

This study deals with the missing link prediction problem: the problem of predicting the existence of missing connections between entities of interest. We address link prediction using coupled analysis of relational datasets represented as…

Machine Learning · Computer Science 2012-08-31 Beyza Ermiş , Evrim Acar , A. Taylan Cemgil

We present DUAL-LOCO, a communication-efficient algorithm for distributed statistical estimation. DUAL-LOCO assumes that the data is distributed according to the features rather than the samples. It requires only a single round of…

Machine Learning · Statistics 2016-08-04 Christina Heinze , Brian McWilliams , Nicolai Meinshausen

Several methods have been proposed to estimate the number of clusters in a dataset; the basic ideal behind all of them has been to study an index that measures inter-cluster separation and intra-cluster cohesion over a range of cluster…

Computer Vision and Pattern Recognition · Computer Science 2016-01-12 Bhaskar Mukhoty , Ruchir Gupta , Y. N. Singh

In many settings, a data curator links records from two files to produce datasets that are shared with secondary analysts. Analysts use the linked files to estimate models of interest, such as regressions. Such two-stage approaches do not…

Methodology · Statistics 2025-11-18 Xueyan Hu , Jerome P. Reiter

A model of rank polysemantic distribution with a minimal number of fitting parameters is offered. In an ideal case a parameter-free description of the dependence on the basis of one or several immediate features of the distribution is…

Computation and Language · Computer Science 2007-05-23 Victor Kromer

This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much…

Methodology · Statistics 2021-12-22 Tzu-Jung Huang , Alex Luedtke , Ian W. McKeague

Network surveys of key populations at risk for HIV are an essential part of the effort to understand how the epidemic spreads and how it can be prevented. Estimation of population values from the sample data has been probematical, however,…

Applications · Statistics 2019-09-12 Steve Thompson

The ratio of two densities provides a direct characterization of their differences. We consider the two-sample comparison problem by estimating this ratio given i.i.d. observations from two distributions. To this end, we propose additive…

Methodology · Statistics 2026-04-23 Naoki Awaya , Yuliang Xu , Li Ma

Log-linear models are a family of probability distributions which capture relationships between variables. They have been proven useful in a wide variety of fields such as epidemiology, economics and sociology. The interest in using these…

Machine Learning · Computer Science 2022-12-29 Jan Strappa , Facundo Bromberg

The expected level of linkage disequilibrium (LD) in a finite ideal population at equilibrium is of relevance for many applications in population and quantitative genetics. Several recursion formulae have been proposed during the last…

Populations and Evolution · Quantitative Biology 2013-04-19 Ulrike Ober , Alexander Malinowski , Martin Schlather , Henner Simianer

Increasing nonresponse rates and the cost of data collection are two pressing problems encountered in traditional probability surveys. The proliferation of inexpensive data from web surveys stimulates interest in statistical techniques for…

Methodology · Statistics 2019-12-31 Vladislav Beresovsky
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