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DNA strands serve as a storage medium for $4$-ary data over the alphabet $\{A,T,G,C\}$. DNA data storage promises formidable information density, long-term durability, and ease of replicability. However, information in this intriguing…

Information Theory · Computer Science 2024-08-06 Canberk İrimağzı , Yusuf Uslan , Ahmed Hareedy

In the trace reconstruction problem, an unknown bit string ${\bf x}\in\{0,1 \}^n$ is sent through a deletion channel where each bit is deleted independently with some probability $q\in(0,1)$, yielding a contracted string $\widetilde{\bf…

Probability · Mathematics 2019-06-10 Nina Holden , Russell Lyons

In the trace reconstruction problem, the goal is to reconstruct an unknown string $x$ of length $n$ from multiple traces obtained by passing $x$ through the deletion channel. In the relaxed problem of $approximate$ trace reconstruction, the…

Probability · Mathematics 2021-07-15 Zachary Chase , Yuval Peres

Network codes designed specifically for distributed storage systems have the potential to provide dramatically higher storage efficiency for the same availability. One main challenge in the design of such codes is the exact repair problem:…

Information Theory · Computer Science 2011-09-02 Dimitris S. Papailiopoulos , Jianqiang Luo , Alexandros G. Dimakis , Cheng Huang , Jin Li

Recent work by Smagloy et al. (ISIT 2020) shows that the redundancy of a single-deletion $s$-substitution correcting code is asymptotically at least $(s+1)\log n+o(\log n)$, where $n$ is the length of the codes. They also provide a…

Information Theory · Computer Science 2020-11-24 Wentu Song , Nikita Polyanskii , Kui Cai , Xuan He

DNA is emerging as an increasingly attractive medium for data storage due to a number of important and unique advantages it offers, most notably the unprecedented durability and density. While the technology is evolving rapidly, the…

Emerging Technologies · Computer Science 2022-05-03 Dehui Lin , Yasamin Tabatabaee , Yash Pote , Djordje Jevdjic

DNA synthesis is considered as one of the most expensive components in current DNA storage systems. In this paper, focusing on a common synthesis machine, which generates multiple DNA strands in parallel following a fixed supersequence,we…

Information Theory · Computer Science 2025-05-13 Yajuan Liu , Tolga M. Duman

We investigate the problem of encoding data into an $(n, t)$-break-resilient code ($(n, t)$-BRC), i.e., a collections of sequences of length~$n$ from which the original data can be reconstructed even if they are adversarially broken at up…

Information Theory · Computer Science 2025-09-23 Canran Wang , Jin Sima , Netanel Raviv

In this work, we investigate a challenging problem, which has been considered to be an important criterion in designing codewords for DNA computing purposes, namely secondary structure avoidance in single-stranded DNA molecules. In short,…

Information Theory · Computer Science 2023-02-28 Tuan Thanh Nguyen , Kui Cai , Han Mao Kiah , Duc Tu Dao , Kees A. Schouhamer Immink

In the usual trace reconstruction problem, the goal is to exactly reconstruct an unknown string of length $n$ after it passes through a deletion channel many times independently, producing a set of traces (i.e., random subsequences of the…

Data Structures and Algorithms · Computer Science 2020-12-17 Sami Davies , Miklos Z. Racz , Cyrus Rashtchian , Benjamin G. Schiffer

We consider an \emph{approximate} version of the trace reconstruction problem, where the goal is to recover an unknown string $s\in\{0,1\}^n$ from $m$ traces (each trace is generated independently by passing $s$ through a probabilistic…

Data Structures and Algorithms · Computer Science 2021-07-21 Diptarka Chakraborty , Debarati Das , Robert Krauthgamer

Erasure codes provide a storage efficient alternative to replication based redundancy in (networked) storage systems. They however entail high communication overhead for maintenance, when some of the encoded fragments are lost and need to…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-11-24 Frederique Oggier , Anwitaman Datta

In [1], the authors proposed a new model of DNA storage system that integrates all three steps of retrieval and introduced the concept of DNA-correcting codes, which guarantees that the output of the storage system can be decoded to the…

Information Theory · Computer Science 2023-11-17 Huawei Wu

We consider rate R = k/n causal linear codes that map a sequence of k-dimensional binary vectors {b_t} to a sequence of n-dimensional binary vectors {c_t}, such that each c_t is a function of {b_1,b_2,...,b_t}. Such a code is called anytime…

Information Theory · Computer Science 2011-06-02 Ravi Teja Sukhavasi , Babak Hassibi

Random quantum circuits have played a central role in establishing the computational advantages of near-term quantum computers over their conventional counterparts. Here, we use ensembles of low-depth random circuits with local connectivity…

Quantum Physics · Physics 2021-09-29 Michael J. Gullans , Stefan Krastanov , David A. Huse , Liang Jiang , Steven T. Flammia

Despite their significant advantages over competing technologies, nanopore sequencers are plagued by high error rates, due to physical characteristics of the nanopore and inherent noise in the biological processes. It is thus paramount not…

Information Theory · Computer Science 2025-10-27 Anisha Banerjee , Yonatan Yehezkeally , Antonia Wachter-Zeh , Eitan Yaakobi

With recent high-throughput technology we can synthesize large heterogeneous collections of DNA structures, and also read them all out precisely in a single procedure. Can we use these tools, not only to do things faster, but also to devise…

Data Structures and Algorithms · Computer Science 2021-12-07 Luca Cardelli

Distributed storage systems need to store data redundantly in order to provide some fault-tolerance and guarantee system reliability. Different coding techniques have been proposed to provide the required redundancy more efficiently than…

Information Theory · Computer Science 2016-11-15 Lluis Pamies-Juarez , Henk D. L. Hollmann , Frédérique Oggier

In the context of distributed storage systems, locally repairable codes have become important. In this paper we focus on codes that allow for multi-erasure pattern decoding with low computational effort. Different optimality requirements,…

Information Theory · Computer Science 2025-04-16 Margreta Kuijper , Julia Lieb , Diego Napp

In the trace reconstruction problem, an unknown bit string $x \in \{0,1\}^n$ is observed through the deletion channel, which deletes each bit of $x$ with some constant probability $q$, yielding a contracted string $\widetilde{x}$. How many…

Probability · Mathematics 2016-12-13 Fedor Nazarov , Yuval Peres
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