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Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language…

Computational Engineering, Finance, and Science · Computer Science 2025-09-16 Liuzhenghao Lv , Zongying Lin , Hao Li , Yuyang Liu , Jiaxi Cui , Calvin Yu-Chian Chen , Li Yuan , Yonghong Tian

The feature matching is a basic step in matching different datasets. This article proposes shows a new hybrid model of a pretrained Natural Language Processing (NLP) based model called BERT used in parallel with a statistical model based on…

Databases · Computer Science 2023-03-24 Muhammad Danial Khilji

Physiological signals are high-dimensional time series of great practical values in medical and healthcare applications. However, previous works on its classification fail to obtain promising results due to the intractable data…

Machine Learning · Computer Science 2023-02-13 Wenqiang He , Mingyue Cheng , Qi Liu , Zhi Li

Recent advances in computational methods for designing biological sequences have sparked the development of metrics to evaluate these methods performance in terms of the fidelity of the designed sequences to a target distribution and their…

This paper conducts a comprehensive investigation into applying large language models, particularly on BioBERT, in healthcare. It begins with thoroughly examining previous natural language processing (NLP) approaches in healthcare, shedding…

Artificial Intelligence · Computer Science 2023-10-13 Shyni Sharaf , V. S. Anoop

This paper details the efforts of the WisPerMed team in the BioLaySumm2024 Shared Task on automatic lay summarization in the biomedical domain, aimed at making scientific publications accessible to non-specialists. Large language models…

Computation and Language · Computer Science 2024-09-24 Tabea M. G. Pakull , Hendrik Damm , Ahmad Idrissi-Yaghir , Henning Schäfer , Peter A. Horn , Christoph M. Friedrich

We introduce PPL Bench, a new benchmark for evaluating Probabilistic Programming Languages (PPLs) on a variety of statistical models. The benchmark includes data generation and evaluation code for a number of models as well as…

Accurate information about protein content in the organism is instrumental for a better understanding of human biology and disease mechanisms. While the presence of certain types of proteins can be life-threatening, the abundance of others…

Quantitative Methods · Quantitative Biology 2022-01-19 Dmytro Fishman

The rise of large language models (LLMs) has significantly advanced various natural language processing (NLP) tasks. However, the resource demands of these models pose substantial challenges. Structured pruning is an effective approach to…

Machine Learning · Computer Science 2024-12-17 Changhai Zhou , Yuhua Zhou , Shijie Han , Qian Qiao , Hongguang Li

Unlocking the next generation of biotechnology and therapeutic innovation demands overcoming the inherent complexity and resource-intensity of conventional protein engineering methods. Recent GenAI-powered computational techniques often…

In this thesis, we introduce Bayesian filtering as a principled framework for tackling diverse sequential machine learning problems, including online (continual) learning, prequential (one-step-ahead) forecasting, and contextual bandits. To…

Machine Learning · Statistics 2025-05-13 Gerardo Duran-Martin

Motivation: A perennial challenge for biomedical researchers and clinical practitioners is to stay abreast with the rapid growth of publications and medical notes. Natural language processing (NLP) has emerged as a promising direction for…

Computation and Language · Computer Science 2021-12-16 Robert Tinn , Hao Cheng , Yu Gu , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , Hoifung Poon

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Scientific software is often driven by multiple parameters that affect both accuracy and performance. Since finding the optimal configuration of these parameters is a highly complex task, it extremely common that the software is used…

Computational Engineering, Finance, and Science · Computer Science 2016-08-17 Diego Fabregat-Traver , Ahmed E. Ismail , Paolo Bientinesi

Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained…

Computation and Language · Computer Science 2019-10-21 Jinhyuk Lee , Wonjin Yoon , Sungdong Kim , Donghyeon Kim , Sunkyu Kim , Chan Ho So , Jaewoo Kang

Large language models (LLMs) have achieved remarkable progress in natural language processing, but their high computational and memory costs hinder deployment on resource-constrained devices. Binarization represents the most extreme form of…

Machine Learning · Computer Science 2025-09-30 Xianglong Yan , Tianao Zhang , Zhiteng Li , Haotong Qin , Yulun Zhang

Large language models (LLMs) are typically aligned to a universal set of safety and usage principles intended for broad public acceptability. Yet, real-world applications of LLMs often take place within organizational ecosystems shaped by…

Computation and Language · Computer Science 2025-11-10 Prasoon Varshney , Makesh Narsimhan Sreedhar , Liwei Jiang , Traian Rebedea , Christopher Parisien

The purpose of this study is to introduce software technologies and models and artificial intelligence algorithms to improve the weaknesses of CBT (Cognitive Behavior Therapy) method in psychotherapy. The presentation method for this…

Software Engineering · Computer Science 2021-08-17 Omid Shokrollahi

Model-based testing (MBT) is a method that supports the design and execution of test cases by models that specify the intended behaviors of a system under test. While systematic literature reviews on MBT in general exist, the state of the…

Software Engineering · Computer Science 2024-03-04 Waleed Abdeen , Xingru Chen , Michael Unterkalmsteiner

Neural Machine Translation (NMT) has become a significant technology in natural language processing through extensive research and development. However, the deficiency of high-quality bilingual language pair data still poses a major…

Computation and Language · Computer Science 2024-01-17 Soon-Jae Hwang , Chang-Sung Jeong