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Structured illumination microscopy (SIM) provides images of fluorescent objects at an enhanced resolution greater than that of conventional epifluorescence wide-field microscopy. Initially demonstrated in 1999 to enhance the lateral…

Optics · Physics 2022-03-09 James D. Manton

Imaging techniques such as functional near-infrared spectroscopy (fNIRS) and diffuse optical tomography (DOT) achieve deep, non-invasive sensing in turbid media, but they are constrained by the photon budget. Wavefront shaping (WFS) can…

Optics · Physics 2026-04-21 Pablo Jara , Arthur Goetschy , Hui Cao , Alexey Yamilov

Fluorescence lifetime imaging microscopy (FLIM) is an important technique to understand the chemical micro-environment in cells and tissues since it provides additional contrast compared to conventional fluorescence imaging. When two…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Varun Mannam , Xiaotong Yuan , Scott Howard

Sub-diffraction resolution, gentle sample illumination, and the possibility to image in multiple colors make Structured Illumination Microscopy (SIM) an imaging technique which is particularly well suited for live cell observations. Here,…

We describe an experimental system that allows one to easily access the dispersion curve of exciton-polaritons in a microcavity. Our approach is based on two spatial light modulators (SLM), one for changing the excitation angles (momenta),…

Mesoscale and Nanoscale Physics · Physics 2015-06-03 P. Mai , B. Pressl , M. Sassermann , Z. Vörös , G. Weihs , C. Schneider , A. Löffler , S. Höfling , A. Forchel

We propose a triply-resonant electro-optic modulator architecture which maximizes modulation efficiency using simultaneous resonant enhancement of the RF drive signal, the optical pump, and the generated optical sideband. Optical…

Optics · Physics 2020-05-20 Hayk Gevorgyan , Anatol Khilo , Yossef Ehrlichman , Miloš Popović

This research will examine the computational methods to calculate the nonlinear optical process of second harmonic generation (SHG) that will be hypothesized to be present during lithium ion insertion into silicon nanowires. First it will…

Optics · Physics 2021-10-19 Donald C. Boone

Spatial light modulators enable arbitrary control of the intensity of optical light fields and facilitate a variety of applications in biology, astronomy and atomic, molecular and optical physics. For coherent light fields, holography,…

A double-ridge waveguide is designed for efficient and robust second-harmonic generation (SHG) using the thin-film lithium-niobate-on-insulator (LNOI) platform. Perfect phase matching (PhM) is achieved between the fundamental waveguide mode…

Quantum spectroscopy seeks to probe chemical systems using nonclassical light, which has properties that are qualitatively and quantitatively different than conventional light sources. One promising technique uses intensity-correlated twin…

Dynamical control of the nonlinear optical properties of solids -- with light itself -- will be essential for future ultrafast photonic technologies. Previously, methods to modulate nonlinear processes including second-harmonic generation…

High-numerical-aperture (NA) oblique plane microscopy enables noninvasive fluorescence imaging of subcellular dynamics without requiring radical sample modification. However, performance degrades at depth in multicellular specimens as…

Digital micromirror devices are a popular type of spatial light modulators for wavefront shaping applications. While they offer several advantages when compared to liquid crystal modulators, such as polarization insensitivity and…

Optics · Physics 2023-11-29 R. Gutiérrez-Cuevas , S. M. Popoff

We demonstrate a significant resolution enhancement beyond the conventional limit in multiphoton microscopy (MPM) using saturated excitation of fluorescence. Our technique achieves super-resolved imaging by temporally modulating the…

Fluorescence lifetime imaging microscopy (FLIM) is a well-established technique with numerous imaging applications. Yet, one of the limitations of FLIM is that it provides information about the emitting state only. Here, we present an…

Biological Physics · Physics 2023-10-27 Pavel Malý , Dita Strachotová , Aleš Holoubek , Petr Heřman

Time-invariant photonic structures amplify or absorb light based on their intrinsic material gain or loss. The coherent interference of multiple beams in space, e.g., in a resonator, can be exploited to tailor the wave interaction with…

The nonlinear optical radiation of an integrated lithium niobate microcavity is demonstrated, which has been neglected in previous studies of nonlinear photonic devices. We find that the nonlinear coupling between confined optical modes on…

Performing linear operations using optical devices is a crucial building block in many fields ranging from telecommunication to optical analogue computation and machine learning. For many of these applications, key requirements are…

Silicon photonics provides a versatile platform for large-scale integration of optical functions, but its weak intrinsic nonlinear response limits the realization of active, intensity-dependent functionalities. Hybrid integration of…

In second harmonic generation, the phase of the optical field is doubled which has important implication. Here the phase doubling effect is utilized to solve a long-standing challenge in power scaling of single frequency laser. When a…

Optics · Physics 2022-01-19 Xin Zeng , Shuzhen Cui , Xin Cheng , Yan Feng