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The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations to the model have commonly been used for the analysis of time-resolved genome…

Populations and Evolution · Quantitative Biology 2016-11-21 Nuno R. Nené , Ville Mustonen , Christopher J. R. Illingworth

The purpose of this article is to study some asymptotic properties of the \Lambda-Wright-Fisher process with selection. This process represents the frequency of a disadvantaged allele. The resampling mechanism is governed by a finite…

Probability · Mathematics 2014-03-06 Clement Foucart

We investigate a new model for populations evolving in a spatial continuum. This model can be thought of as a spatial version of the Lambda-Fleming-Viot process. It explicitly incorporates both small scale reproduction events and large…

Probability · Mathematics 2010-03-22 N. H. Barton , A. M. Etheridge , A. Veber

In this paper we consider two continuous-mass population models as analogues of logistic branching random walks, one is supported on a finite trait space and the other one is supported on an infinite trait space. For the first model with…

Probability · Mathematics 2013-04-18 Anton Bovier , Shi-Dong Wang

In the context of Markov processes, we show a new scheme to derive dual processes and a duality function based on a boson representation. This scheme is applicable to a case in which a generator is expressed by boson creation and…

Statistical Mechanics · Physics 2015-05-14 Jun Ohkubo

We view sequential design as a model selection problem to determine which new observation is expected to be the most informative, given the existing set of observations. For estimating a probability distribution on a bounded interval, we…

Methodology · Statistics 2018-07-19 Madhurima Nath , Stephen Eubank

We introduce a new Gaussian process, a generalization of both fractional and subfractional Brownian motions, which could serve as a good model for a larger class of natural phenomena. We study its main stochastic properties and some…

Probability · Mathematics 2017-04-10 Mounir Zili

In subdivided populations, migration acts together with selection and genetic drift and determines their evolution. Building up on a recently proposed method, which hinges on the emergence of a time scale separation between local and global…

Populations and Evolution · Quantitative Biology 2015-03-24 Pierangelo Lombardo , Andrea Gambassi , Luca Dall'Asta

The formula for the probability of fixation of a new mutation is widely used in theoretical population genetics and molecular evolution. Here we derive a series of identities, inequalities and approximations for the exact probability of…

Populations and Evolution · Quantitative Biology 2015-03-10 David M. McCandlish , Charles L. Epstein , Joshua B. Plotkin

In this article, a biallelic reversible mutation model with linear and quadratic selection is analyzed. The approach reconnects to one proposed by Kimura ( Possibility of extensive neutral evolution under stabilizing selection with special…

Populations and Evolution · Quantitative Biology 2021-03-30 Claus Vogl , Lynette Caitlin Mikula

The survival of natural populations may be greatly affected by environmental conditions that vary in space and time. We look at a population residing in two locations (patches) coupled by migration, in which the local conditions fluctuate…

Statistical Mechanics · Physics 2021-08-11 Tal Agranov , Guy Bunin

Genetic data are often used to infer demographic history and changes or detect genes under selection. Inferential methods are commonly based on models making various strong assumptions: demography and population structures are supposed…

Populations and Evolution · Quantitative Biology 2020-07-28 Clotilde Lepers , Sylvain Billiard , Matthieu Porte , Sylvie Méléard , Viet Chi Tran

The appropriate description of fluctuations within the framework of evolutionary game theory is a fundamental unsolved problem in the case of finite populations. The Moran process recently introduced into this context [Nowak et al., Nature…

Statistical Mechanics · Physics 2007-05-23 Jens Christian Claussen , Arne Traulsen

We present a new model for seed banks, where direct ancestors of individuals may have lived in the near as well as the very far past. The classical Wright-Fisher model, as well as a seed bank model with bounded age distribution considered…

Probability · Mathematics 2013-07-02 Jochen Blath , Adrian González Casanova , Noemi Kurt , Dario Spanò

In this paper we present a variational technique that handles coarse-graining and passing to a limit in a unified manner. The technique is based on a duality structure, which is present in many gradient flows and other variational…

Analysis of PDEs · Mathematics 2017-03-06 Manh Hong Duong , Agnes Lamacz , Mark A. Peletier , Upanshu Sharma

The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit…

Populations and Evolution · Quantitative Biology 2015-06-30 Oskar Hallatschek , Lukas Geyrhofer

In genetics the Moran model describes the neutral evolution of a bi-allelic gene in a population of haploid individuals subjected to mutations. We show in this paper that this model can be mapped into an influence dynamical process on…

Populations and Evolution · Quantitative Biology 2015-03-17 Marcus A. M. de Aguiar , Yaneer Bar-Yam

In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and…

Populations and Evolution · Quantitative Biology 2009-11-13 Charles L. Epstein

Fundamental properties of macroscopic gene-mating dynamic evolutionary systems are investigated. We focus on a single locus, any number of alleles in a two-gender dioecious population, for a large class of systems within population…

Populations and Evolution · Quantitative Biology 2020-07-22 Juven Wang , Jiunn-Wei Chen

Widely used models in genetics include the Wright-Fisher diffusion and its moment dual, Kingman's coalescent. Each has a multilocus extension but under neither extension is the sampling distribution available in closed-form, and their…

Probability · Mathematics 2015-06-24 Paul A. Jenkins , Paul Fearnhead , Yun S. Song