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Investigation of cell structure is hardly imaginable without bright-field microscopy. Numerous modifications such as depth-wise scanning or videoenhancement make this method being state-of-the-art. This raises a question what maximal…

Image and Video Processing · Electrical Eng. & Systems 2020-10-29 Kirill Lonhus , Renata Rychtarikova , Ganna Platonova , Dalibor Stys

Formation of a bright-field microscopic image of a transparent phase object is described in terms of elementary geometrical optics. Our approach is based on the premise that image replicates the intensity distribution (real or virtual) at…

Optics · Physics 2018-02-14 A. K. Khitrin , M. A. Model

Light-field microscopy represents a promising solution for microscopic volumetric imaging, thanks to its capability to encode information on multiple planes in a single acquisition. This is achieved through its peculiar simultaneous capture…

Current biological and medical research is aimed at obtaining a detailed spatiotemporal map of a live cell's interior to describe and predict cell's physiological state. We present here an algorithm for complete 3-D modelling of cellular…

Quantitative Methods · Quantitative Biology 2017-04-03 Renata Rychtarikova , Tomas Nahlik , Kevin Shi , Daria Malakhova , Petr Machacek , Rebecca Smaha , Jan Urban , Dalibor Stys

It is generally assumed that a high spatial resolution of a microscope requires a large numerical aperture of the imaging lens or detector. In this study, the information limit of 15 pm is achieved in transmission electron microscopy using…

Materials Science · Physics 2024-01-08 Haozhi Sha , Jizhe Cui , Wenfeng Yang , Rong Yu

Optical stellar interferometers have demonstrated milli-arcsecond resolution with few apertures spaced hundreds of meters apart. To obtain rich direct images, many apertures will be needed, for a better sampling of the incoming wavefront.…

Instrumentation and Methods for Astrophysics · Physics 2014-09-17 Arun Surya , Swapan K. Saha , Antoine Labeyrie

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

Quantitative Methods · Quantitative Biology 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Low-light optical imaging refers to the use of cameras to capture images with minimal photon flux. This area has broad application to diverse fields, including optical microscopy for biological studies. In such studies, it is important to…

Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little better than…

Soft Condensed Matter · Physics 2017-10-18 Matthew Bierbaum , Brian D. Leahy , Alexander A. Alemi , Itai Cohen , James P. Sethna

Phase-contrast microscopy converts the optical phase introduced by transparent, unlabeled specimens into modulation in the intensity image. Modern phase imaging techniques are capable of quantifying phase shift at each point in the field of…

In conventional x-ray ptychography, diffraction data is collected by scanning a sample through a monochromatic, and spatially coherent, x-ray beam. A high-resolution image is then retrieved using an iterative algorithm. Combined with a scan…

Optics · Physics 2025-08-26 Wiebe Stolp , Silvia Cipiccia , Darren Batey , Matthieu Boone

Recent advances in snapshot multispectral (MS) imaging have enabled compact, low-cost spectral sensors for consumer and mobile devices. By capturing richer spectral information than conventional RGB sensors, these systems can enhance key…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Luca Cogo , Marco Buzzelli , Simone Bianco , Javier Vazquez-Corral , Raimondo Schettini

A blind compressive sensing algorithm is proposed to reconstruct hyperspectral images from spectrally-compressed measurements.The wavelength-dependent data are coded and then superposed, mapping the three-dimensional hyperspectral datacube…

Computer Vision and Pattern Recognition · Computer Science 2015-10-28 Xin Yuan , Tsung-Han Tsai , Ruoyu Zhu , Patrick Llull , David Brady , Lawrence Carin

Aberration-corrected scanning transmission electron microscopes (STEM) provide sub-angstrom lateral resolution; however, the large convergence angle greatly reduces the depth of field. For microscopes with a small depth of field,…

Materials Science · Physics 2011-12-15 Robert Hovden , Huolin L. Xin , David A. Muller

The expansion of telecommunications incurs increasingly severe crosstalk and interference, and a physical layer cognitive method, called blind source separation (BSS), can effectively address these issues. BSS requires minimal prior…

Signal Processing · Electrical Eng. & Systems 2023-03-22 Weipeng Zhang , Alexander Tait , Chaoran Huang , Thomas Ferreira de Lima , Simon Bilodeau , Eric Blow , Aashu Jha , Bhavin J. Shastri , Paul Prucnal

Information multiplexing is important for biomedical imaging and chemical sensing. In this paper, we report a microscopy imaging technique, termed state-multiplexed Fourier ptychography (FP), for information multiplexing and coherent-state…

Optics · Physics 2014-05-12 Siyuan Dong , Radhika Shiradkar , Pariksheet Nanda , Guoan Zheng

We use an empirical approach to characterize the effect of charge-transfer efficiency (CTE) losses in images taken with the Wide-Field Channel of the Advanced Camera for Surveys. The study is based on profiles of warm pixels in 168 dark…

Instrumentation and Methods for Astrophysics · Physics 2015-05-19 Jay Anderson , Luigi R. Bedin

Image simulation remains under-exploited for the most widely used biological phase microscopy methods, because of difficulties in simulating partially coherent illumination. We describe an open-source toolbox, microlith…

Optics · Physics 2014-05-14 Shalin B. Mehta , Rudolf Oldenbourg

Despite its broad availability, volumetric information acquisition from Bright-Field Microscopy (BFM) is inherently difficult due to the projective nature of the acquisition process. We investigate the prediction of 3D cell instances from a…

Computer Vision and Pattern Recognition · Computer Science 2022-06-10 Shervin Dehghani , Benjamin Busam , Nassir Navab , Ali Nasseri
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