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Despite the massive costs and widespread harms of substance use, most individuals with substance use disorders (SUDs) receive no treatment at all. Digital therapeutics platforms are an emerging low-cost and low-barrier means of extending…

Systems and Control · Electrical Eng. & Systems 2025-04-03 Eric Pulick , Yonatan Mintz

A key challenge in satisficing planning is to use multiple heuristics within one heuristic search. An aggregation of multiple heuristic estimates, for example by taking the maximum, has the disadvantage that bad estimates of a single…

Artificial Intelligence · Computer Science 2021-04-13 David Speck , André Biedenkapp , Frank Hutter , Robert Mattmüller , Marius Lindauer

We consider the problem of optimally allocating a limited number of resources across time to maximize revenue under stochastic demands. This formulation is relevant in various areas of control, such as supply chain, ticket revenue…

Optimization and Control · Mathematics 2025-10-01 Alexandros E. Tzikas , Nazim Kemal Ure , Mansur Arief , Mykel J. Kochenderfer , Stephen P. Boyd

In this paper we propose a method for sparse dynamic allocation of resources to bound the risk of spreading processes, such as epidemics and wildfires, using convex optimization and dynamic programming techniques. Here, risk is defined as…

Systems and Control · Electrical Eng. & Systems 2021-10-18 Vera L. J. Somers , Ian R. Manchester

Platform trials are randomized clinical trials that allow simultaneous comparison of multiple interventions, usually against a common control. Arms to test experimental interventions may enter and leave the platform over time. This implies…

Methodology · Statistics 2024-04-12 Marta Bofill Roig , Ekkehard Glimm , Tobias Mielke , Martin Posch

Urban water distribution systems hold a critical and strategic position in preserving public health and industrial growth. Despite the ubiquity of these urban systems, aging infrastructure, and increased risk of terrorism, decision support…

Other Computer Science · Computer Science 2014-07-03 Amin Rasekh , Kelly Brumbelow

Most recommender systems (RS) research assumes that a user's utility can be maximized independently of the utility of the other agents (e.g., other users, content providers). In realistic settings, this is often not true---the dynamics of…

Machine Learning · Computer Science 2020-08-20 Martin Mladenov , Elliot Creager , Omer Ben-Porat , Kevin Swersky , Richard Zemel , Craig Boutilier

This study develops and analyzes an extended Susceptible, Infected, Hospitalized and Recovered (SIHR) model incorporating time dependent control functions to capture preventive measures (e.g., distancing, mask use) and resource limited…

Populations and Evolution · Quantitative Biology 2025-10-01 Liban Ismail , Yahyeh Souleiman , Saraless Nadarajah , Abdisalam Hassan

We propose a reinforcement learning method for estimating an optimal dynamic treatment regime for survival outcomes with dependent censoring. The estimator allows the failure time to be conditionally independent of censoring and dependent…

Methodology · Statistics 2022-05-13 Hunyong Cho , Shannon T. Holloway , David J. Couper , Michael R. Kosorok

Modelling epidemics via classical population-based models suffers from shortcomings that so-called individual-based models are able to overcome, as they are able to take heterogeneity features into account, such as super-spreaders, and…

Optimization and Control · Mathematics 2022-05-16 C. Courtès , E. Franck , K. Lutz , L. Navoret , Y. Privat

In survival contexts, substantial literature exists on estimating optimal treatment regimes, where treatments are assigned based on personal characteristics to maximize the survival probability. These methods assume that a set of covariates…

Methodology · Statistics 2025-07-24 Junwen Xia , Zishu Zhan , Jingxiao Zhang

For a general optimal control problem for dynamical systems with hybrid dynamics, we study the dependency of the optimal cost and of the value function on the initial conditions, parameters, and perturbations. We show that upper and lower…

Optimization and Control · Mathematics 2021-12-22 Berk Altın , Ricardo G. Sanfelice

Individualized treatment rules can lead to better health outcomes when patients have heterogeneous responses to treatment. Very few individualized treatment rule estimation methods are compatible with a multi-treatment observational study…

Recently there has been a lot of interest in monitoring and identifying changes in dynamic networks, which has led to the development of a variety of monitoring methods. Unfortunately, these methods have not been systematically compared;…

Computation · Statistics 2019-05-27 Lisha Yu , Inez M. Zwetsloot , Nathaniel T. Stevens , James D. Wilson , Kwok Leung Tsui

The increasing recognition of the association between adverse human health conditions and many environmental substances as well as processes has led to the need to monitor them. An important problem that arises in environmental statistics…

Applications · Statistics 2020-02-05 Yu Wang , Nhu D. Le , James V. Zidek

Dynamic treatment regimes (DTRs) are critical to precision medicine, optimizing long-term outcomes through personalized, real-time decision-making in evolving clinical contexts, but require careful supervision for unsafe treatment risks.…

Machine Learning · Computer Science 2025-06-10 Yishan Shen , Yuyang Ye , Hui Xiong , Yong Chen

Efficient sampling in biomolecular simulations is critical for accurately capturing the complex dynamical behaviors of biological systems. Adaptive sampling techniques aim to improve efficiency by focusing computational resources on the…

Biomolecules · Quantitative Biology 2024-10-22 Hassan Nadeem , Diwakar Shukla

We propose novel resource allocation algorithms that have the objective of finding a good tradeoff between resource reuse and interference avoidance in wireless networks. To this end, we first study properties of functions that relate the…

Signal Processing · Electrical Eng. & Systems 2018-01-19 Qi Liao , R. L. G. Cavalcante

In this article, we focus on a periodic resource allocation problem applied to a dynamical system which comes from a biological system. More precisely, we consider a system with $N$ resources and $N$ activities, each activity use the…

Numerical Analysis · Mathematics 2022-06-01 Olivier Bernard , Liu-Di Lu , Julien Salomon

Randomized clinical trials (RCTs) are widely considered the gold standard for evaluating the effectiveness of new treatments or interventions in drug development. Still, they may not be feasible in certain cases, such as with rare diseases…

Methodology · Statistics 2025-08-05 Di Ran , Fanni Zhang , Sima Shahsavari , Kristine Broglio , Alasdair Henderson , Binbing Yu
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