Related papers: Vanishing parameter for an optimal control problem…
This article discusses an optimal control problem for a phase field model of two immiscible incompressible fluid flow, incorporating surface tension effects. The optimal control problem is defined with a $L^2$-cost functional and subject to…
In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…
The uncontrolled proliferation of cancer cells and their interaction with healthy tissue poses a major challenge in oncology. This manuscript develops and analyzes mathematical models that describe tumor response to radiotherapy by…
In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…
We study an optimal distributed control problem associated to a stochastic Cahn-Hilliard equation with a classical double-well potential and Wiener multiplicative noise, where the control is represented by a source-term in the definition of…
We consider the inverse problem of parameter estimation in a diffuse interface model for tumour growth. The model consists of a fourth-order Cahn-Hilliard system and contains three phenomenological parameters: the tumour proliferation rate,…
This paper is concerned with a boundary control problem for the Cahn--Hilliard equation coupled with dynamic boundary conditions. In order to handle the control problem, we restrict our analysis to the case of regular potentials defined on…
In the present contribution we study the sliding mode control (SMC) problem for a diffuse interface tumor growth model coupling a viscous Cahn-Hilliard type equation for the phase variable with a reaction-diffusion equation for the…
Background: The vast computational resources that became available during the past decade enabled the development and simulation of increasingly complex mathematical models of cancer growth. These models typically involve many free…
Mean field optimal control problems are a class of optimization problems that arise from optimal control when applied to the many body setting. In the noisy case one has a set of controllable stochastic processes and a cost function that is…
In this paper we consider an optimal control problem arising from a chemotherapeutic drug treatment for tumor cells in a living tissue. The mathematical model for the interaction of chemotherapeutic drug and the normal, tumor and immune…
We study some optimal control problems associated to the evolution of two isothermal, incompressible, immisible fluids in a two-dimensional bounded domain. The Cahn- Hilliard-Navier-Stokes model consists of a Navier-Stokes equation…
In this paper, we study an optimal control problem for a viscous Cahn--Hilliard system with zero Neumann boundary conditions in which a hyperbolic relaxation term involving the second time derivative of the chemical potential has been added…
We propose and analyze an optimal control problem associated with a Keller-Segel type parabolic system with chemoattraction, modeling the glioblastoma growth in a bi-dimensional bounded domain, influenced by the presence of oxygen where the…
We investigate a control process described by a linear system of ordinary differential equations with a noise of special type acting to the control parameter. As the cost functional the probability of the final state vector to enter to a…
In this paper we present a method for estimating unknown parameters that appear on an avascular, spheric tumour growth model. The model for the tumour is based on nutrient driven growth of a continuum of live cells, whose birth and death…
The purpose of this work is the formulation of optimality conditions for phase-field optimal control problems. The forward problem is first stated as an abstract nonlinear optimization problem, and then the necessary optimality conditions…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…
In this paper we study optimal control problem for non local Cahn-Hilliard-Brinkman system which models phase separation of binary fluids in porous media. We consider the system in two dimensional bounded domain with regular potential. We…
We address an optimal control problem governed by a system coupling a Brinkman-type momentum equation for the velocity field with a sixth-order Cahn-Hilliard equation for the phase variable, incorporating curvature effects in the free…