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Centrality metrics aim to identify the most relevant nodes in a network. In literature, a broad set of metrics exists, either measuring local or global centrality characteristics. Nevertheless, when networks exhibit a high spectral gap, the…
This paper proposes a uniqueness Shapley measure to compare the extent to which different variables are able to identify a subject. Revealing the value of a variable on subject $t$ shrinks the set of possible subjects that $t$ could be. The…
The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness. Using the individual based model of Wright and Fisher, we…
Capture-recapture methods aim to estimate the size of a closed population on the basis of multiple incomplete enumerations of individuals. In many applications, the individual probability of being recorded is heterogeneous in the…
Pedigree data contain family history information that is used to analyze hereditary diseases. These clinical data sets may contain duplicate records due to the same family visiting a clinic multiple times or a clinician entering multiple…
Diversities have recently been developed as multiway metrics admitting clear and useful notions of hyperconvexity and tight span. In this note we consider the analytic properties of diversities, in particular the generalizations of uniform…
We study how the Shannon entropy of sequences produced by an information source converges to the source's entropy rate. We synthesize several phenomenological approaches to applying information theoretic measures of randomness and memory to…
Identifying disease-associated genes enables the development of precision medicine and the understanding of biological processes. Genome-wide association studies (GWAS), gene expression data, biological pathway analysis, and protein network…
Dimension reduction, widely used in science, maps high-dimensional data into low-dimensional space. We investigate a basic mathematical model underlying the techniques of stochastic neighborhood embedding (SNE) and its popular variant…
Observed differences in mean phenotypic values across human groups have attracted renewed interest with the rise of large-scale genomic studies and polygenic risk prediction. However, the genetic basis of these differences is far more…
Motivated by applications in neuroanatomy, we propose a novel methodology for estimating the heritability which corresponds to the proportion of phenotypic variance which can be explained by genetic factors. Estimating this quantity for…
The sequential hypothesis testing problem is a class of statistical analyses where the sample size is not fixed in advance. Instead, the decision-process takes in new observations sequentially to make real-time decisions for testing an…
Despite the celebrated popularity of Graph Neural Networks (GNNs) across numerous applications, the ability of GNNs to generalize remains less explored. In this work, we propose to study the generalization of GNNs through a novel…
Recent works have demonstrated that the convergence rate of a nonparametric density estimator can be greatly improved by using a low-rank estimator when the target density is a convex combination of separable probability densities with…
I extend the traditional SAR, which has achieved status of ecological law and plays a critical role in global biodiversity assessment, to the general (alpha- or beta-diversity in Hill numbers) diversity area relationship (DAR). The…
Graph Neural Networks (GNNs) have shown remarkable performance in structured data modeling tasks such as node classification. However, mainstream approaches generally rely on a large number of trainable parameters and fixed aggregation…
The Matrix-based Renyi's entropy enables us to directly measure information quantities from given data without the costly probability density estimation of underlying distributions, thus has been widely adopted in numerous statistical…
A topological approach to the study of genetic recombination, based on persistent homology, was introduced by Chan, Carlsson, and Rabad\'an in 2013. This associates a sequence of signatures called barcodes to genomic data sampled from an…
Clinical adoption of human genome sequencing requires methods with known accuracy of genotype calls at millions or billions of positions across a genome. Previous work showing discordance amongst sequencing methods and algorithms has made…
Signal-to-Noise Ratios (SNRs) and the Shannon-Hartley channel capacity are metrics that help define the loss of known information while transferring data through a noisy channel. These metrics cannot be used for quantifying the opposite…