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Reconstruction of neuroanatomy is a fundamental problem in neuroscience. Stochastic expression of colors in individual cells is a promising tool, although its use in the nervous system has been limited due to various sources of variability…

Neurons and Cognition · Quantitative Biology 2017-01-24 Uygar Sümbül , Douglas Roussien , Fei Chen , Nicholas Barry , Edward S. Boyden , Dawen Cai , John P. Cunningham , Liam Paninski

Protein subcellular localization is an important factor in normal cellular processes and disease. While many protein localization resources treat it as static, protein localization is dynamic and heavily influenced by biological context.…

Molecular Networks · Quantitative Biology 2022-12-13 Chris S. Magnano , Anthony Gitter

Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging,…

With the success of deep learning, recent efforts have been focused on analyzing how learned networks make their classifications. We are interested in analyzing the network output based on the network structure and information flow through…

Machine Learning · Computer Science 2018-02-13 Sandeep Konam , Ian Quah , Stephanie Rosenthal , Manuela Veloso

Automatic segmentation of neuronal topology is critical for handling large scale neuroimaging data, as it can greatly accelerate neuron annotation and analysis. However, the intricate morphology of neuronal branches and the occlusions among…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Huayu Fu , Jiamin Li , Haozhi Qu , Xiaolin Hu , Zengcai Guo

Arbor is a software library designed for efficient simulation of large-scale networks of biological neurons with detailed morphological structures. It combines customizable neuronal and synaptic mechanisms with high-performance computing,…

Computational Engineering, Finance, and Science · Computer Science 2026-02-16 Jannik Luboeinski , Sebastian Schmitt , Shirin Shafiee , Thorsten Hater , Fabian Bösch , Christian Tetzlaff

Understanding the relation between cortical neuronal network structure and neuronal activity is a fundamental unresolved question in neuroscience, with implications to our understanding of the mechanism by which neuronal networks evolve…

Deep learning has led to significant advances in artificial intelligence, in part, by adopting strategies motivated by neurophysiology. However, it is unclear whether deep learning could occur in the real brain. Here, we show that a deep…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jordan Guergiuev , Timothy P. Lillicrap , Blake A. Richards

Graph neural networks have emerged as a specialized branch of deep learning, designed to address problems where pairwise relations between objects are crucial. Recent advancements utilize graph convolutional neural networks to extract…

Emerging Technologies · Computer Science 2024-04-29 Shay Snyder , Victoria Clerico , Guojing Cong , Shruti Kulkarni , Catherine Schuman , Sumedh R. Risbud , Maryam Parsa

Morphological neurons, that is morphological operators such as dilation and erosion with learnable structuring elements, have intrigued researchers for quite some time because of the power these operators bring to the table despite their…

Machine Learning · Computer Science 2022-12-15 Ranjan Mondal , Sanchayan Santra , Soumendu Sundar Mukherjee , Bhabatosh Chanda

Modern artificial neural networks, including convolutional neural networks and vision transformers, have mastered several computer vision tasks, including object recognition. However, there are many significant differences between the…

Computer Vision and Pattern Recognition · Computer Science 2023-01-26 Tiago Oliveira , Tiago Marques , Arlindo L. Oliveira

Real-world networks often benefit from capturing both local and global interactions. Inspired by multi-modal analysis in brain imaging, where structural and functional connectivity offer complementary views of network organization, we…

Neural and Evolutionary Computing · Computer Science 2025-08-11 Yang Li , Luopeiwen Yi , Tananun Songdechakraiwut

With the advances of data-driven machine learning research, a wide variety of prediction problems have been tackled. It has become critical to explore how machine learning and specifically deep learning methods can be exploited to analyse…

Machine Learning · Computer Science 2021-11-09 David Ahmedt-Aristizabal , Mohammad Ali Armin , Simon Denman , Clinton Fookes , Lars Petersson

In deep neural networks, better results can often be obtained by increasing the complexity of previously developed basic models. However, it is unclear whether there is a way to boost performance by decreasing the complexity of such models.…

Machine Learning · Computer Science 2021-09-07 Junran Wu , Jianhao Li , Yicheng Pan , Ke Xu

Graphs are general and powerful data representations which can model complex real-world phenomena, ranging from chemical compounds to social networks; however, effective feature extraction from graphs is not a trivial task, and much work…

Connected networks are a fundamental structure of neurobiology. Understanding these networks will help us elucidate the neural mechanisms of computation. Mathematically speaking these networks are `graphs' - structures containing objects…

Neurons and Cognition · Quantitative Biology 2020-10-20 Carl J. Nelson , Stephen Bonner

Understanding how brain structure and function interact is key to explaining intelligence yet modeling them jointly is challenging as the structural and functional connectome capture complementary aspects of organization. We introduced…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Badhan Mazumder , Sir-Lord Wiafe , Aline Kotoski , Vince D. Calhoun , Dong Hye Ye

The brain is likely the most complex organ, given the variety of functions it controls, the number of cells it comprises, and their corresponding diversity. Studying and identifying neurons, the brain's primary building blocks, is a crucial…

Machine Learning · Computer Science 2023-06-02 Ofek Ophir , Orit Shefi , Ofir Lindenbaum

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina

Shape information is crucial for human perception and cognition, and should therefore also play a role in cognitive AI systems. We employ the interdisciplinary framework of conceptual spaces, which proposes a geometric representation of…

Machine Learning · Computer Science 2021-11-17 Lucas Bechberger , Kai-Uwe Kühnberger