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Understanding the timing of the peak of a disease outbreak forms an important part of epidemic forecasting. In many cases, such information is essential for planning increased hospital bed demand and for designing of public health…

Populations and Evolution · Quantitative Biology 2023-11-27 Jacob Curran-Sebastian , Lorenzo Pellis , Ian Hall , Thomas House

Doubly intractable distributions arise in many settings, for example in Markov models for point processes and exponential random graph models for networks. Bayesian inference for these models is challenging because they involve intractable…

Computation · Statistics 2019-04-03 Jaewoo Park , Murali Haran

Emerging infectious diseases and climate change are two of the major challenges in 21st century. Although over the past decades, highly-resolved mathematical models have contributed in understanding dynamics of infectious diseases and are…

Populations and Evolution · Quantitative Biology 2025-10-13 Julia Bicker , René Schmieding , Michael Meyer-Hermann , Martin J. Kühn

We present a parsimonious stochastic model for valuation of options on the fraction of infected individuals during an epidemic. The underlying stochastic dynamical system is a stochastic differential version of the SIR model of mathematical…

Computational Finance · Quantitative Finance 2020-03-26 Andrew Lesniewski , Nicholas Lesniewski

Traditional epidemic detection algorithms make decisions using only local information. We propose a novel approach that explicitly models spatial information fusion from several metapopulations. Our method also takes into account…

Computation · Statistics 2015-09-15 Michael Ludkovski , Katherine Shatskikh

This paper considers the problem of forecasting mortality rates. A large number of models have already been proposed for this task, but they generally have the disadvantage of either estimating the model in a two-step process, possibly…

Applications · Statistics 2023-05-26 Patrik Andersson , Mathias Lindholm

Genomic surveillance of infectious diseases allows monitoring circulating and emerging variants and quantifying their epidemic potential. However, due to the high costs associated with genomic sequencing, only a limited number of samples…

The spatial scan statistic is widely used to detect disease clusters in epidemiological surveillance. Since the seminal work by~\cite{kulldorff1997}, numerous extensions have emerged, including methods for defining scan regions, detecting…

Methodology · Statistics 2025-02-11 Takayuki Kawashima , Daisuke Yoneoka , Yuta Tanoue , Akifumi Eguchi , Shuhei Nomura

The Time Since Infection (TSI) models, which use disease surveillance data to model infectious diseases, have become increasingly popular due to their flexibility and capacity to address complex disease control questions. However, a notable…

Methodology · Statistics 2025-01-10 Jiasheng Shi , Yizhao Zhou , Jing Huang

This study aims to estimate the parameters of a stochastic exposed-infected epidemiological model for the transmission dynamics of notifiable infectious diseases, based on observations related to isolated cases counts only. We use the…

Applications · Statistics 2024-04-15 Ibrahim Bouzalmat , Benoîte de Saporta , Solym M. Manou-Abi

Network epidemiology has become a core framework for investigating the role of human contact patterns in the spreading of infectious diseases. In network epidemiology represents the contact structure as a network of nodes (individuals)…

Populations and Evolution · Quantitative Biology 2014-06-10 Petter Holme

This paper is concerned with a contemporary Bayesian approach to the effect of temperature on developmental rates. We develop statistical methods using recent computational tools to model four commonly used ecological non-linear…

Applications · Statistics 2021-05-03 Marios Kondakis , Nikolaos Demiris , Ioannis Ntzoufras , Nikos E. Papanikolaou

The dynamics of infection spread in populations has received popular attention since the outbreak of Covid-19 and many statistical models have been developed. One of the interesting areas of research is short-time dynamics in confined,…

Physics and Society · Physics 2025-01-22 Rahul Sheshanarayana , Prateek K. Jha

Approximating complex probability densities is a core problem in modern statistics. In this paper, we introduce the concept of Variational Inference (VI), a popular method in machine learning that uses optimization techniques to estimate…

Machine Learning · Computer Science 2021-11-23 Ankush Ganguly , Samuel W. F. Earp

We propose a numerical method for approximating integro-differential equations arising in age-of-infection epidemic models. The method is based on a non-standard finite differences approximation of the integral term appearing in the…

Numerical Analysis · Mathematics 2024-07-22 Eleonora Messina , Mario Pezzella , Antonia Vecchio

An individual-based model of the infectious disease spread among the urban population is considered. A system of stochastic equations, which describes changes in quantities of four population groups, susceptible, exposed, infected…

Populations and Evolution · Quantitative Biology 2011-11-11 Vasiliy Leonenko

Mechanistic mathematical models of within-host viral dynamics are tools for understanding how a virus' biology and its interaction with the immune system shape the infectivity of a host. The biology of the process is encoded by the…

Applications · Statistics 2025-12-11 Dylan J. Morris , Lauren Kennedy , Andrew J. Black

Neuroscience has recently made much progress, expanding the complexity of both neural-activity measurements and brain-computational models. However, we lack robust methods for connecting theory and experiment by evaluating our new big…

Quantitative Methods · Quantitative Biology 2023-07-06 Heiko H. Schütt , Alexander D. Kipnis , Jörn Diedrichsen , Nikolaus Kriegeskorte

The past decades have seen enormous improvements in computational inference based on statistical models, with continual enhancement in a wide range of computational tools, in competition. In Bayesian inference, first and foremost, MCMC…

Computation · Statistics 2015-05-12 Peter J. Green , Krzysztof Łatuszyński , Marcelo Pereyra , Christian P. Robert

Network models are increasingly used to study infectious disease spread. Exponential Random Graph models have a history in this area, with scalable inference methods now available. An alternative approach uses mechanistic network models.…

Methodology · Statistics 2024-01-11 Octavious Smiley , Till Hoffmann , Jukka-Pekka Onnela