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MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Data scaling has revolutionized research fields like natural language processing, computer vision, and robotics control, providing foundation models with remarkable multi-task and generalization capabilities. In this paper, we investigate…

Systems and Control · Electrical Eng. & Systems 2025-03-27 Shaohuai Liu , Lin Dong , Chao Tian , Le Xie

Model-based Bayesian reinforcement learning has generated significant interest in the AI community as it provides an elegant solution to the optimal exploration-exploitation tradeoff in classical reinforcement learning. Unfortunately, the…

Artificial Intelligence · Computer Science 2012-06-18 Stephane Ross , Joelle Pineau

Deep learning models trained on large data sets have been widely successful in both vision and language domains. As state-of-the-art deep learning architectures have continued to grow in parameter count so have the compute budgets and times…

A protein's function depends critically on its conformational ensemble, a collection of energy weighted structures whose balance depends on temperature and environment. Though recent deep learning (DL) methods have substantially advanced…

Biomolecules · Quantitative Biology 2026-01-09 Myeongsang Lee , Lauren L. Porter

We present scalable hybrid-parallel algorithms for training large-scale 3D convolutional neural networks. Deep learning-based emerging scientific workflows often require model training with large, high-dimensional samples, which can make…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-07-28 Yosuke Oyama , Naoya Maruyama , Nikoli Dryden , Erin McCarthy , Peter Harrington , Jan Balewski , Satoshi Matsuoka , Peter Nugent , Brian Van Essen

Most uses of machine learning today involve training a model from scratch for a particular task, or sometimes starting with a model pretrained on a related task and then fine-tuning on a downstream task. Both approaches offer limited…

Machine Learning · Computer Science 2022-05-26 Andrea Gesmundo , Jeff Dean

The customizable nature of deep learning models have allowed them to be successful predictors in various disciplines. These models are often trained with respect to thousands or millions of instances for complicated problems, but the…

Machine Learning · Computer Science 2019-12-24 Drimik Roy Chowdhury , Muhammad Firmansyah Kasim

Deep neural networks have shown great success in many diverse fields. The training of these networks can take significant amounts of time, compute and energy. As datasets get larger and models become more complex, the exploration of model…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-08 Siddharth Samsi , Michael Jones , Mark M. Veillette

Predictive coding networks are neural models that perform inference through an iterative energy minimization process, whose operations are local in space and time. While effective in shallow architectures, they suffer significant…

Machine Learning · Computer Science 2025-10-13 Chang Qi , Matteo Forasassi , Thomas Lukasiewicz , Tommaso Salvatori

Value-oriented forecasts for two-stage power system operational problems have been demonstrated to reduce cost, but prove to be computationally challenging for large-scale systems because the underlying optimization problem must be…

Optimization and Control · Mathematics 2025-05-20 Mehrnoush Ghazanfariharandi , Robert Mieth

Predicting material properties is crucial for designing better batteries, semiconductors, and medical devices. Deep learning helps scientists quickly find promising materials by predicting their energy, forces, and stresses. Companies scale…

Machine Learning · Computer Science 2025-09-29 Akshay Trikha , Kyle Chu , Advait Gosai , Parker Szachta , Eric Weiner

Scaling model capacity has been vital in the success of deep learning. For a typical network, necessary compute resources and training time grow dramatically with model size. Conditional computation is a promising way to increase the number…

Machine Learning · Computer Science 2018-11-14 Louis Kirsch , Julius Kunze , David Barber

Deep structured models are widely used for tasks like semantic segmentation, where explicit correlations between variables provide important prior information which generally helps to reduce the data needs of deep nets. However, current…

Machine Learning · Computer Science 2018-11-02 Colin Graber , Ofer Meshi , Alexander Schwing

Currently the only techniques for sharing governance of a deep learning model are homomorphic encryption and secure multiparty computation. Unfortunately, neither of these techniques is applicable to the training of large neural networks…

Machine Learning · Computer Science 2018-12-17 Miljan Martic , Jan Leike , Andrew Trask , Matteo Hessel , Shane Legg , Pushmeet Kohli

Model merging is a technique that combines multiple large pretrained models into a single model with enhanced performance and broader task adaptability. It has gained popularity in large pretrained model development due to its ability to…

Machine Learning · Computer Science 2024-09-30 Yu Zhou , Xingyu Wu , Jibin Wu , Liang Feng , Kay Chen Tan

Over the last couple of years, machine learning parameterizations have emerged as a potential way to improve the representation of sub-grid processes in Earth System Models (ESMs). So far, all studies were based on the same three-step…

Atmospheric and Oceanic Physics · Physics 2020-03-25 Stephan Rasp

Neural Networks (NNs) are effective models for refining the accuracy of molecular dynamics, opening up new fields of application. Typically trained bottom-up, atomistic NN potential models can reach first-principle accuracy, while…

Chemical Physics · Physics 2025-05-19 Paul Fuchs , Stephan Thaler , Sebastien Röcken , Julija Zavadlav

In forecasting multiple time series, accounting for the individual features of each sequence can be challenging. To address this, modern deep learning methods for time series analysis combine a shared (global) model with local layers,…

Machine Learning · Computer Science 2025-02-14 Luca Butera , Giovanni De Felice , Andrea Cini , Cesare Alippi

Gradient-based optimization has been critical to the success of machine learning, updating a single set of parameters to minimize a single loss. A growing number of applications rely on a generalization of this, where we have a bilevel or…

Machine Learning · Computer Science 2024-07-02 Jonathan Lorraine