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We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of…

Molecular Networks · Quantitative Biology 2015-11-12 Matteo Polettini , Artur Wachtel , Massimiliano Esposito

We perform a fully self-consistent 3-D numerical simulation for a compressible, dissipative magneto-plasma driven by large-scale perturbations, that contain a fairly broader spectrum of characteristic modes, ranging from largest scales to…

Space Physics · Physics 2015-05-13 Dastgeer Shaikh , B. Dasgupta , Q. Hu , G. P. Zank

The adaptive and surprising emergent properties of biological materials self-assembled in far-from-equilibrium environments serve as an inspiration for efforts to design nanomaterials and their properties. In particular, controlling the…

Statistical Mechanics · Physics 2023-07-07 Shriram Chennakesavalu , Sreekanth K. Manikandan , Frank Hu , Grant M. Rotskoff

We develop a framework describing the dynamics and thermodynamics of open non-ideal reaction-diffusion systems, which embodies Flory-Huggins theories of mixtures and chemical reaction network theories. Our theory elucidates the mechanisms…

Molecular Networks · Quantitative Biology 2024-12-05 Francesco Avanzini , Timur Aslyamov , Étienne Fodor , Massimiliano Esposito

Life is commonly described as a self-organized, far-from-equilibrium process that maintains internal order by consuming free energy and exporting entropy. This thermodynamic view underlies diverse theoretical frameworks -- from autopoiesis…

Biological Physics · Physics 2025-12-23 Didier Sornette , Virgile Troude

The study of spreading processes often analyzes networks at different resolutions, e.g., at the level of individuals or countries, but it is not always clear how properties at one resolution can carry over to another. Accordingly, in this…

Physics and Society · Physics 2024-12-04 Baike She , Matthew Hale

Microscopic machines utilize free energy to create and maintain out-of-equilibrium organization in virtually all living things. Often this takes the form of converting the free energy stored in nonequilibrium chemical potential differences…

Statistical Mechanics · Physics 2019-08-23 Steven J. Large , David A. Sivak

This thesis focuses on three fundamental aspects of biological systems; namely, entropy production, Bayesian mechanics, and the free-energy principle. The contributions are threefold: 1) We compute the entropy production for a greater class…

Mathematical Physics · Physics 2024-10-16 Lancelot Da Costa

We demonstrate and characterize a first-principles approach to modeling the mass action dynamics of metabolism. Starting from a basic definition of entropy expressed as a multinomial probability density using Boltzmann probabilities with…

Chemical Physics · Physics 2024-07-10 William R. Cannon , Samuel Britton , Mikahl Banwarth-Kuhn , Mark Alber

Active systems, which are driven out of equilibrium by local non-conservative forces, can adopt unique behaviors and configurations. An important challenge in the design of novel materials which utilize such properties is to precisely…

Soft Condensed Matter · Physics 2022-08-09 Gregory Rassolov , Laura Tociu , Étienne Fodor , Suriyanarayanan Vaikuntanathan

Active networks made of biopolymers and motor proteins are valuable bioinspired systems that have been used in the last decades to study the cytoskeleton and its self-organization under mechanical stimulation. Different techniques are…

Soft Condensed Matter · Physics 2023-05-15 Vahid Nasirimarekani , Olinka Ramìrez-Soto , Stefan Karpitschka , Isabella Guido

Inspired by natural cooling processes, dissipation has become a promising approach for preparing low-energy states of quantum systems. However, the potential of dissipative protocols remains unclear beyond certain commuting Hamiltonians.…

Quantum Physics · Physics 2026-02-27 Yongtao Zhan , Zhiyan Ding , Jakob Huhn , Johnnie Gray , John Preskill , Garnet Kin-Lic Chan , Lin Lin

Active materials take advantage of their internal sources of energy to self-organize in an automated manner. This feature provides a novel opportunity to design micron-scale machines with minimal required control. However, self-organization…

Soft Condensed Matter · Physics 2021-01-22 Zijie Qu , Jialong Jiang , Heun Jin Lee , Rob Phillips , Shahriar Shadkhoo , Matt Thomson

It is proposed that the spatial (and temporal) patterns spontaneously appearing in dissipative systems maximize the energy flow through the pattern forming interface. In other words - the patterns maximize the entropy growth rate in an…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Kestutis Staliunas

Chemical processes in closed systems are poorly controllable since they always relax to equilibrium. Living systems avoid this fate and give rise to a much richer diversity of phenomena by operating under nonequilibrium conditions. Recent…

Chemical Physics · Physics 2019-09-11 Emanuele Penocchio , Riccardo Rao , Massimiliano Esposito

Active matter and driven systems exhibit statistical fluctuations in density and particle positions, providing an indirect indicator of dissipation across multiple length and time scales. Here, we quantitatively relate these measurable…

Statistical Mechanics · Physics 2024-12-19 Aishani Ghosal , Jason R. Green

Thanks to a constant energy input, active matter can self-assemble into phases with complex architectures and functionalities such as living clusters that dynamically form, reshape and break-up, which are forbidden in equilibrium materials…

Soft Condensed Matter · Physics 2019-03-27 Falko Schmidt , Benno Liebchen , Hartmut Löwen , Giovanni Volpe

The actin cytoskeleton is remarkably adaptable and multifunctional. It often organizes into nematic bundles such as contractile rings or stress fibers. However, how a uniform and isotropic actin gel self-organizes into dense nematic bundles…

This paper presents a distributed voltage regulation method based on multi-agent system control and network self-organization for a large distribution network. The network autonomously organizes itself into small subnetworks through the…

Systems and Control · Electrical Eng. & Systems 2022-02-02 Badr Al Faiya , Dimitrios Athanasiadis , Minjiang Chen , Stephen McArthur , Ivana Kockar , Haowei Lu , Francisco de Leon

It is well known that many biochemical processes in the cell such as gene regulation, growth signals and activation of ion channels, rely on mechanical stimuli. However, the mechanism by which mechanical signals propagate through cells is…

Soft Condensed Matter · Physics 2017-04-05 Adar Sonn-Segev , Anne Bernheim-Groswasser , Yael Roichman