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The numerical analysis of the diffraction features rendered by transmission electron microscopy (TEM) typically relies either on classical approximations (Monte Carlo simulations) or quantum paraxial tomography (the multislice method and…

Materials Science · Physics 2017-03-20 Samantha Rudinsky , Angel S. Sanz , Raynald Gauvin

We study the direct and an inverse source problem for the radiative transfer equation arising in optical molecular imaging. We show that for generic absorption and scattering coefficients, the direct problem is well-posed and the inverse…

Analysis of PDEs · Mathematics 2008-03-31 Plamen Stefanov , Gunther Uhlmann

Scattering hinders the passage of light through random media and consequently limits the usefulness of optical techniques for sensing and imaging. Thus, methods for increasing the transmission of light through such random media are of…

Optics · Physics 2014-06-23 Curtis Jin , Raj Rao Nadakuditi , Eric Michielssen , Stephen Rand

We propose a method to reconstruct the optical absorption of a highly-scattering medium probed by diffuse light. The method consists of learning the optical detection system and then using this result to reconstruct the absorption. Our…

Optics · Physics 2025-10-08 Zijian Wang , Andreas Hauptmann , Lu Lu , John C. Schotland

Optical diffraction tomography (ODT) has emerged as a powerful label-free three-dimensional (3D) bioimaging techniques for observing living cells and thin tissue layers. We report a new reflection-mode ODT (rODT) method for imaging thick…

Inverse problems are of great importance in astrophysics for deriving information about the physical characteristics of hot optically thin plasma sources from their EUV and X-ray spectra. We describe and test an iterative method developed…

Solar and Stellar Astrophysics · Physics 2014-01-24 F. F. Goryaev , S. Parenti , A. M. Urnov , S. N. Oparin , J. -F. Hochedez , F. Reale

The Rytov approximation has been commonly used to obtain reconstructed images for optical tomography. However, the method requires linearization of the nonlinear inverse problem. Here, we demonstrate nonlinear Rytov approximations by…

Medical Physics · Physics 2024-11-26 Chi Zhang , Manabu Machida

Inverse scattering aims to infer information about a hidden object by using the received scattered waves and training data collected from forward mathematical models. Recent advances in computing have led to increasing attention towards…

Applications · Statistics 2023-05-03 Chih-Li Sung , Yao Song , Ying Hung

Optical diffraction tomography (ODT) is an interferometric microscopy technique capable of measuring 3-D refractive index (RI) distribution of transparent samples. Multiple 2-D holograms of a sample illuminated with various angles are…

We study the inverse problem in Optical Tomography of determining the optical properties of a medium $\Omega\subset\mathbb{R}^n$, with $n\geq 3$, under the so-called diffusion approximation. We consider the time-harmonic case where $\Omega$…

Analysis of PDEs · Mathematics 2021-11-16 Jason Curran , Romina Gaburro , Clifford J. Nolan , Erkki Somersalo

Optical Diffraction Tomography (ODT) is a powerful non-invasive imaging technique widely used in biological and medical applications. While significant progress has been made in transmission configuration, reflection ODT remains challenging…

Optics · Physics 2026-05-14 Thomas Wasik , Victor Barolle , Alexandre Aubry , Josselin Garnier

Based on diffraction theory and the propagation of the light, Fourier optics is a powerful tool allowing the estimation of a visible-range imaging system to transfer the spatial frequency components of an object. The analyses of the imaging…

General Physics · Physics 2018-06-05 Stephane Perrin , Paul Montgomery

The interest in using optical transition radiation (OTR) in high energy (multiGeV) beam diagnostics has motivated theoretical and experimental investigations on the limitations brought by diffraction on the attainable resolution. This paper…

Accelerator Physics · Physics 2007-05-23 X. Artru , R. Chehab , K. Honkavaara , A. Variola

The inverse radiative transfer problem finds broad applications in medical imaging, atmospheric science, astronomy, and many other areas. This problem intends to recover the optical properties, denoted as absorption and scattering…

Numerical Analysis · Mathematics 2017-08-08 Qin Li , Ruiwen Shu , Li Wang

It has been argued that in atomic-resolution transmission electron microscopy (TEM) of sparse weakly scattering structures, such as small biological molecules, multiple electron scattering usually has only a small effect, while the…

Optics · Physics 2021-11-16 T. E. Gureyev , H. M. Quiney , A. Kozlov , D. M. Paganin , G. Schmalz , L. J. Allen

Measurement of the optical transmission matrix (TM) of an opaque material is an advanced form of space-variant aberration correction. Beyond imaging, TM-based methods are emerging in a range of fields including optical communications,…

The optical transmission matrix (TM) characterizes the transmission properties of a sample. We show a novel experimental procedure for measuring the TM of light waves in a slab geometry based on sampling the light field on a hexagonal…

Optics · Physics 2020-03-11 Pritam Pai , Jeroen Bosch , Allard P. Mosk

Various imaging techniques have significantly enhanced our ability to visualize objects embedded within complex media such as biological tissues, fog, atmosphere, or various turbid media. Optical imaging, in particular, offers multiple…

Optics · Physics 2025-05-05 Mingwei He , Sujit K. Sahoo , Chengyuan Xiao , Cuong Dang

An ideal imaging system provides a spatial resolution that is ultimately dictated by the numerical aperture (NA) of the illumination and collection optics. In biological tissue, resolution is further affected by scattering limiting the…

High-resolution optical microscopy has transformed biological imaging, yet its resolution and contrast deteriorate with depth due to multiple light scattering. Conventional correction strategies typically approximate the medium as one or a…