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Sequences of neural activity arise in many brain areas, including cortex, hippocampus, and central pattern generator circuits that underlie rhythmic behaviors like locomotion. While network architectures supporting sequence generation vary…

Neurons and Cognition · Quantitative Biology 2022-08-16 Caitlyn Parmelee , Juliana Londono Alvarez , Carina Curto , Katherine Morrison

Complex networks evolve and vary their structure as time goes by. In particular, the links in those networks have both a sign and a directionality. To understand their structural principles, we measure the network motifs, which are patterns…

Physics and Society · Physics 2023-06-28 Youngjai Park , Mi Jin Lee , Seung-Woo Son

Spatio-temporal network dynamics is an emergent property of many complex systems which remains poorly understood. We suggest a new approach to its study based on the analysis of dynamical motifs -- small subnetworks with periodic and…

Disordered Systems and Neural Networks · Physics 2007-05-23 Valentin P. Zhigulin

Deep neural networks excel in mapping genomic DNA sequences to associated readouts (e.g., protein-DNA binding). Beyond prediction, the goal of these networks is to reveal to scientists the underlying motifs (and their syntax) which drive…

Genomics · Quantitative Biology 2024-10-10 Alex M. Tseng , Gokcen Eraslan , Tommaso Biancalani , Gabriele Scalia

A straight-line drawing of a graph is a monotone drawing if for each pair of vertices there is a path which is monotonically increasing in some direction, and it is called a strongly monotone drawing if the direction of monotonicity is…

Computational Geometry · Computer Science 2016-01-08 Stefan Felsner , Alexander Igamberdiev , Philipp Kindermann , Boris Klemz , Tamara Mchedlidze , Manfred Scheucher

We study a graph-theoretic property known as robustness, which plays a key role in certain classes of dynamics on networks (such as resilient consensus, contagion and bootstrap percolation). This property is stronger than other graph…

Social and Information Networks · Computer Science 2015-03-20 Haotian Zhang , Elaheh Fata , Shreyas Sundaram

Networks of neurons in some brain areas are flexible enough to encode new memories quickly. Using a standard firing rate model of recurrent networks, we develop a theory of flexible memory networks. Our main results characterize networks…

Neurons and Cognition · Quantitative Biology 2015-02-25 Carina Curto , Anda Degeratu , Vladimir Itskov

This paper, we explore the dynamics of threshold networks on undirected signed graphs. Much attention has been dedicated to understanding the convergence and long-term behavior of this model. Yet, an open question persists: How does the…

Discrete Mathematics · Computer Science 2024-12-23 Eric Goles , Pedro Montealegre , Martín Ríos-Wilson , Sylvain Sené

Great part of the interest in complex networks has been motivated by the presence of structured, frequently non-uniform, connectivity. Because diverse connectivity patterns tend to result in distinct network dynamics, and also because they…

Disordered Systems and Neural Networks · Physics 2009-11-13 Paulino R. Villas Boas , Francisco A. Rodrigues , Gonzalo Travieso , Luciano da F. Costa

One of the most important concepts in biological network analysis is that of network motifs, which are patterns of interconnections that occur in a given network at a frequency higher than expected in a random network. In this work we are…

Discrete Mathematics · Computer Science 2020-05-29 Diego P Rubert , Eloi Araujo , Marco A Stefanes , Jens Stoye , Fábio V Martinez

Networks are a fundamental tool for modeling complex systems in a variety of domains including social and communication networks as well as biology and neuroscience. Small subgraph patterns in networks, called network motifs, are crucial to…

Social and Information Networks · Computer Science 2018-01-08 Ashwin Paranjape , Austin R. Benson , Jure Leskovec

This paper introduces a generalization of Convolutional Neural Networks (CNNs) to graphs with irregular linkage structures, especially heterogeneous graphs with typed nodes and schemas. We propose a novel spatial convolution operation to…

Machine Learning · Computer Science 2019-07-23 Aravind Sankar , Xinyang Zhang , Kevin Chen-Chuan Chang

The study of motifs in networks can help researchers uncover links between the structure and function of networks in biology, sociology, economics, and many other areas. Empirical studies of networks have identified feedback loops,…

Physics and Society · Physics 2021-05-12 Alice C. Schwarze , Mason A. Porter

Let $\Lambda(T)$ denote the set of leaves in a tree $T$. One natural problem is to look for a spanning tree $T$ of a given graph $G$ such that $\Lambda(T)$ is as large as possible. This problem is called maximum leaf number, and it is a…

Combinatorics · Mathematics 2026-02-19 Peter Bradshaw , Tomáš Masařík , Jana Novotná , Ladislav Stacho

Robust heteroclinic networks are invariant sets that can appear as attractors in symmetrically coupled or otherwise constrained dynamical systems. These networks may have a very complicated structure that is poorly understood and determined…

Adaptation and Self-Organizing Systems · Physics 2015-06-12 Peter Ashwin , Claire Postlethwaite

Phylogenetic networks are becoming of increasing interest to evolutionary biologists due to their ability to capture complex non-treelike evolutionary processes. From a combinatorial point of view, such networks are certain types of rooted…

Combinatorics · Mathematics 2019-10-21 Katharina T. Huber , Guillaume E. Scholz

Multiplex networks are a powerful framework for representing systems with multiple types of interactions among a common set of entities. Understanding their structure requires statistical tools capturing higher-order cross-layer…

Statistics Theory · Mathematics 2026-03-30 Karl Sawaya , Sofia Olhede

Graphs can model complicated interactions between entities, which naturally emerge in many important applications. These applications can often be cast into standard graph learning tasks, in which a crucial step is to learn low-dimensional…

Machine Learning · Computer Science 2023-07-04 Xuexin Chen , Ruichu Cai , Yuan Fang , Min Wu , Zijian Li , Zhifeng Hao

Motifs are the fundamental components of complex systems. The topological structure of networks representing complex systems and the frequency and distribution of motifs in these networks are intertwined. The complexities associated with…

Social and Information Networks · Computer Science 2020-05-21 Ali Jazayeri , Christopher C. Yang

Network science can offer fundamental insights into the structural and functional properties of complex systems. For example, it is widely known that neuronal circuits tend to organize into basic functional topological modules, called…

Adaptation and Self-Organizing Systems · Physics 2022-08-03 Matteo Zambra , Alberto Testolin , Amos Maritan