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Evaluating intervention effects on multiple outcomes is a central research goal in a wide range of quantitative sciences. It is thereby common to compare interventions among each other and with a control across several, potentially highly…

Heteroskedasticity poses several methodological challenges in designing valid and powerful procedures for simultaneous testing of composite null hypotheses. In particular, the conventional practice of standardizing or re-scaling…

Methodology · Statistics 2025-09-04 Bowen Gang , Trambak Banerjee

Covariance and Hessian matrices have been analyzed separately in the literature for classification problems. However, integrating these matrices has the potential to enhance their combined power in improving classification performance. We…

Machine Learning · Computer Science 2024-10-10 Agus Hartoyo , Jan Argasiński , Aleksandra Trenk , Kinga Przybylska , Anna Błasiak , Alessandro Crimi

In many problems involving generalized linear models, the covariates are subject to measurement error. When the number of covariates p exceeds the sample size n, regularized methods like the lasso or Dantzig selector are required. Several…

Methodology · Statistics 2018-01-23 Øystein Sørensen , Arnoldo Frigessi , Magne Thoresen

A Bayesian multivariate model with a structured covariance matrix for multi-way nested data is proposed. This flexible modeling framework allows for positive and for negative associations among clustered observations, and generalizes the…

Methodology · Statistics 2024-08-27 Stef Baas , Richard J. Boucherie , Jean-Paul Fox

Multivariate time series present many challenges, especially when they are high dimensional. The paper's focus is twofold. First, we address the subject of consistently estimating the autocovariance sequence; this is a sequence of matrices…

Statistics Theory · Mathematics 2015-06-03 Carsten Jentsch , Dimitris N. Politis

Regression models with both high-dimensional responses and covariates have attracted growing attention. Standard multivariate regression models become inadequate when the response variables depend not only on observed covariates but also on…

Methodology · Statistics 2026-05-01 Jing Ouyang , Chengyu Cui , Yunxiao Chen , Kean Ming Tan , Gongjun Xu

In practice, observations are often contaminated by noise, making the resulting sample covariance matrix to be an information-plus-noise-type covariance matrix. Aiming to make inferences about the spectra of the underlying true covariance…

Statistics Theory · Mathematics 2015-08-25 Ningning Xia , Xinghua Zheng

Many inference techniques for multivariate data analysis assume that the rows of the data matrix are realizations of independent and identically distributed random vectors. Such an assumption will be met, for example, if the rows of the…

Statistics Theory · Mathematics 2015-12-31 Peter D. Hoff

Latent variable models are popularly used to measure latent factors (e.g., abilities and personalities) from large-scale assessment data. Beyond understanding these latent factors, the covariate effect on responses controlling for latent…

Methodology · Statistics 2026-01-12 Jing Ouyang , Chengyu Cui , Kean Ming Tan , Gongjun Xu

The multivariate linear regression model is an important tool for investigating relationships between several response variables and several predictor variables. The primary interest is in inference about the unknown regression coefficient…

Statistics Theory · Mathematics 2017-09-13 Daniel J. Eck

Estimation of covariance matrices or their inverses plays a central role in many statistical methods. For these methods to work reliably, estimated matrices must not only be invertible but also well-conditioned. In this paper we present an…

Methodology · Statistics 2014-08-06 Eric C. Chi , Kenneth Lange

We propose a new testing procedure of heteroskedasticity in high-dimensional linear regression, where the number of covariates can be larger than the sample size. Our testing procedure is based on residuals of the Lasso. We demonstrate that…

Statistics Theory · Mathematics 2022-11-01 Akira Shinkyu

Frequently, clinical trials and observational studies involve complex event history data with multiple events. When the observations are independent, the analysis of such studies can be based on standard methods for multi-state models.…

Methodology · Statistics 2020-06-30 Giorgos Bakoyannis

Multivariate meta-analysis of test accuracy studies when tests are evaluated in terms of sensitivity and specificity at more than one threshold represents an effective way to synthesize results by fully exploiting the data, if compared to…

Methodology · Statistics 2019-01-29 Annamaria Guolo , Duc Khanh To

In many practical situations we would like to estimate the covariance matrix of a set of variables from an insufficient amount of data. More specifically, if we have a set of $N$ independent, identically distributed measurements of an $M$…

Probability · Mathematics 2010-10-05 Thomas L. Marzetta , Gabriel H. Tucci , Steven H. Simon

Tens of thousands of simultaneous hypothesis tests are routinely performed in genomic studies to identify differentially expressed genes. However, due to unmeasured confounders, many standard statistical approaches may be substantially…

Methodology · Statistics 2025-03-18 Jin-Hong Du , Larry Wasserman , Kathryn Roeder

Analysis of covariance is a crucial method for improving precision of statistical tests for factor effects in randomized experiments. However, existing solutions suffer from one or more of the following limitations: (i) they are not…

Methodology · Statistics 2024-12-24 Konstantin Emil Thiel , Paavo Sattler , Arne C Bathke , Georg Zimmermann

The covariance matrix plays a fundamental role in many modern exploratory and inferential statistical procedures, including dimensionality reduction, hypothesis testing, and regression. In low-dimensional regimes, where the number of…

Methodology · Statistics 2024-11-12 Philippe Boileau , Nima S. Hejazi , Mark J. van der Laan , Sandrine Dudoit

In this work, we consider a multivariate regression model with one-sided errors. We assume for the regression function to lie in a general H\"{o}lder class and estimate it via a nonparametric local polynomial approach that consists of…

Statistics Theory · Mathematics 2021-02-11 Leonie Selk , Charles Tillier , Orlando Marigliano