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Objective: Association between acute ambient fine particulate matter (PM2.5, aerodynamic diameter less than 2.5 and cardiovascular events are well documented. However, it remains unclear whether acute exposure to PM2.5 acts as a trigger for…

Numerous studies have examined the associations between long-term exposure to fine particulate matter (PM2.5) and adverse health outcomes. Recently, many of these studies have begun to employ high-resolution predicted PM2.5 concentrations,…

Methodology · Statistics 2022-11-29 Kevin P. Josey , Priyanka deSouza , Xiao Wu , Danielle Braun , Rachel Nethery

Tobacco use remains a leading preventable contributor to serious health conditions in the United States, notably chronic obstructive pulmonary disease (COPD) and severe COVID-19 complications. Within Louisiana's Medicaid population, tobacco…

Quantitative Methods · Quantitative Biology 2025-03-20 Yead Rahman , Prerna Dua

We evaluated the sensitivity of estimated PM2.5 and NO2 health impacts to varying key input parameters and assumptions including: 1) the spatial scale at which impacts are estimated, 2) using either a single concentration-response function…

Laboratory experiments have shown that cardiovascular diseases are positively correlated to the concentration of ambient air pollutants, such as SO2, NO2, PM10, etc. It has also been repeatedly reported in many countries that increased…

Applications · Statistics 2013-08-08 Menghui Li , Dasheng Luo , Chenghua Cao , Xiaochuan Pan , Qixin Wang

Air pollution is a major risk factor for global health, with both ambient and household air pollution contributing substantial components of the overall global disease burden. One of the key drivers of adverse health effects is fine…

In 2017 an estimated 3 billion people used polluting fuels and technologies as their primary cooking solution, with 3.8 million deaths annually attributed to household exposure to the resulting fine particulate matter air pollution.…

We develop a causal inference approach to estimate the number of adverse health events prevented by large-scale air quality regulations via changes in exposure to multiple pollutants. This approach is motivated by regulations that impact…

Applications · Statistics 2019-09-23 Rachel C. Nethery , Fabrizia Mealli , Jason D. Sacks , Francesca Dominici

Cardiovascular diseases (CVD) remain one of the leading causes of hospitalization in Brazil. Exposure to air pollutants such as PM$_{10}$ $\mu$m, NO$_2$, and SO$_2$ has been associated with the worsening of these diseases, especially in…

The harmful relationship between heatwaves and health has been extensively documented in medical and epidemiological literature. However, most evidence is associational and cannot be interpreted causally unless strong assumptions are made.…

The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels…

Methodology · Statistics 2020-01-09 Georgia Papadogeorgou , Francesca Dominici

In this paper, we undertake a case study to estimate a causal exposure-response function (ERF) for long-term exposure to fine particulate matter (PM$_{2.5}$) and respiratory hospitalizations in socioeconomically disadvantaged children using…

Methodology · Statistics 2024-07-15 Jenny J. Lee , Xiao Wu , Francesca Dominici , Rachel C. Nethery

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in the presence of i) high correlation between the predictors…

Applications · Statistics 2016-02-24 Silvia Liverani , Aurore Lavigne , Marta Blangiardo

While human mobility plays a crucial role in determining air pollution exposures and health risks, research to-date has assessed risks based solely on residential location. Here we leveraged a database of ~ 130 million workers in the US and…

Motivated by analyzing a national data base of annual air pollution and cardiovascular disease mortality rate for 3100 counties in the U.S. (areal data), we develop a novel statistical framework to automatically detect spatially varying…

Applications · Statistics 2015-11-19 Shuo Chen , Chengsheng Jiang , Lance Waller

We propose a new approach for estimating causal effects when the exposure is measured with error and confounding adjustment is performed via a generalized propensity score (GPS). Using validation data, we propose a regression calibration…

Investigating the health impacts of wildfire smoke requires data on people's exposure to fine particulate matter (PM$_{2.5}$) across space and time. In recent years, it has become common to use machine learning models to fill gaps in…

Forest fires impact on soil, water and biota resources has been widely researched. Although forest fires profoundly impact the atmosphere and air quality across the ecosystems, much less research has been developed to examine its impact on…

Flooding is one of the most disruptive and costliest climate-related disasters and presents an escalating threat to population health due to climate change and urbanization patterns. Previous studies have investigated the consequences of…

Applications · Statistics 2023-09-26 Sarika Aggarwal , Jie K. Hu , Jonathan A. Sullivan , Robbie M. Parks , Rachel C. Nethery