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Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical…

Clinical text classification is an important problem in medical natural language processing. Existing studies have conventionally focused on rules or knowledge sources-based feature engineering, but only a few have exploited effective…

Computation and Language · Computer Science 2018-07-23 Liang Yao , Chengsheng Mao , Yuan Luo

Recruiting patients to participate in clinical trials can be challenging and time-consuming. Usually, participation in a clinical trial is initiated by a healthcare professional and proposed to the patient. Promoting clinical trials…

Computation and Language · Computer Science 2025-03-21 Mathilde Aguiar , Pierre Zweigenbaum , Nona Naderi

Automatic extraction of clinical concepts is an essential step for turning the unstructured data within a clinical note into structured and actionable information. In this work, we propose a clinical concept extraction model for automatic…

Computation and Language · Computer Science 2018-11-28 Henghui Zhu , Ioannis Ch. Paschalidis , Amir Tahmasebi

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

Objective: The n2c2/UW SDOH Challenge explores the extraction of social determinant of health (SDOH) information from clinical notes. The objectives include the advancement of natural language processing (NLP) information extraction…

Computation and Language · Computer Science 2023-02-15 Kevin Lybarger , Meliha Yetisgen , Özlem Uzuner

Benchmarking drug efficacy is a critical step in clinical trial design and planning. The challenge is that much of the data on efficacy endpoints is stored in scientific papers in free text form, so extraction of such data is currently a…

Objective: to provide a scoping review of papers on clinical natural language processing (NLP) tasks that use publicly available electronic health record data from a cohort of patients. Materials and Methods: We searched six databases,…

Clinical trials are central to medical progress because they help improve understanding of human health and the healthcare system. They play a key role in discovering new ways to detect, prevent, or treat diseases, and it is essential that…

Computation and Language · Computer Science 2025-10-16 Surya Tejaswi Yerramsetty , Almas Fathimah

Clinical trial eligibility matching is a critical yet often labor-intensive and error-prone step in medical research, as it ensures that participants meet precise criteria for safe and reliable study outcomes. Recent advances in Natural…

Machine Learning · Computer Science 2025-03-04 Muhammad Talha Sharif , Abdul Rehman

Identification of key variables such as medications, diseases, relations from health records and clinical notes has a wide range of applications in the clinical domain. n2c2 2022 provided shared tasks on challenges in natural language…

Computation and Language · Computer Science 2025-07-01 Shouvon Sarker , Xishuang Dong , Lijun Qian

We present the motivation, experience and learnings from a data challenge conducted at a large pharmaceutical corporation on the topic of subgroup identification. The data challenge aimed at exploring approaches to subgroup identification…

Matching patients to clinical trials demands a systematic and reasoned interpretation of documents which require significant expert-level background knowledge, over a complex set of well-defined eligibility criteria. Moreover, this…

Computation and Language · Computer Science 2024-10-01 Mael Jullien , Alex Bogatu , Harriet Unsworth , Andre Freitas

Objective: Identifying study-eligible patients within clinical databases is a critical step in clinical research. However, accurate query design typically requires extensive technical and biomedical expertise. We sought to create a system…

Computation and Language · Computer Science 2023-08-16 Nicholas J Dobbins , Bin Han , Weipeng Zhou , Kristine Lan , H. Nina Kim , Robert Harrington , Ozlem Uzuner , Meliha Yetisgen

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

Clinical patient notes are critical for documenting patient interactions, diagnoses, and treatment plans in medical practice. Ensuring accurate evaluation of these notes is essential for medical education and certification. However, manual…

Computation and Language · Computer Science 2024-01-25 Jingyu Xu , Yifeng Jiang , Bin Yuan , Shulin Li , Tianbo Song

Large Language Models (LLMs) are at the forefront of NLP achievements but fall short in dealing with shortcut learning, factual inconsistency, and vulnerability to adversarial inputs.These shortcomings are especially critical in medical…

Computation and Language · Computer Science 2024-04-09 Mael Jullien , Marco Valentino , André Freitas

Objective: The aim of this study was to build an effective co-reference resolution system tailored for the biomedical domain. Materials and Methods: Experiment materials used in this study is provided by the 2011 i2b2 Natural Language…

Computation and Language · Computer Science 2025-03-14 Ping Chen , David Hinote , Guoqing Chen

Psychiatric intake is a sequential, high-stakes information-gathering process in which clinicians must decide what to ask, in what order, and how to interpret incomplete or ambiguous responses under limited time. Despite growing interest in…

Computation and Language · Computer Science 2026-04-29 Guan Gui , Peter Zandi , Jacob Taylor , Ananya Joshi