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By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium Falciparum on…

Optics · Physics 2016-05-17 Juan Sebastian Totero Gongora , Andrea Fratalocchi

Low-scattering, deep-penetration light transport in biological media remains a pivotal challenge for biophotonic technologies, including biomedical imaging, optical diagnostics, and photodynamic therapy. This review builds upon and extends…

We investigate the physics of an optically-driven micromotor of biological origin. A single, live red blood cell, when placed in an optical trap folds into a rod-like shape. If the trapping laser beam is circularly polarized, the folded RBC…

Biological Physics · Physics 2009-11-11 A. Ghosh , Supurna Sinha , J. A. Dharmadhikari , S. Roy , A. K. Dharmadhikari , J. Samuel , S. Sharma , D. Mathur

We measure the dynamical mechanical properties of human red blood cells. Single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation, and the effect of varying the strain…

Soft Condensed Matter · Physics 2009-11-13 Young-Zoon Yoon , Jurij Kotar , Gilwon Yoon , Pietro Cicuta

The deformability of human red blood cells (RBCs), which comprise almost 99% of the cells in whole blood, is largely related not only to pathophysiological blood flow but also to the levels of intracellular compounds. Therefore, statistical…

The dynamics of red blood cells (RBCs) in oscillatory shear flow was studied using differential equations of three variables: a shape parameter, the inclination angle $\theta$, and phase angle $\phi$ of the membrane rotation. In steady…

Soft Condensed Matter · Physics 2010-06-24 Hiroshi Noguchi

Red blood cells (RBCs) sustain mechanical stresses associated with microcirculatory flow through ATP-driven plasma membrane flickering. This is an active phenomenon driven by motor proteins that regulate interactions between the spectrin…

The functions and elasticities of the cell are largely related to the structures of the cytoskeletons underlying the lipid bi-layer. Among various cell types, the Red Blood Cell (RBC) possesses a relatively simple cytoskeletal structure.…

Biological Physics · Physics 2016-01-20 Lipeng Lai , Xiaofeng Xu , Chwee Teck Lim , Jianshu Cao

Elastic light scattering by mature red blood cells (RBCs) was theoretically and experimentally analyzed with the discrete dipole approximation (DDA) and the scanning flow cytometry (SFC), respectively. SFC permits measurement of angular…

This study investigates the dynamics of red blood cells (RBCs) under the influence of evanescent waves generated by total internal reflection (TIR). Using a 1064 nm laser system and a dual-chamber prism setup, we quantified the mobility of…

We investigate the dynamics of the Red Blood Cell (RBC) in microfluidic channels under oscillatory flows. The simulations employ a hybrid continuum-particle approach, in which the cell membrane and cytosol fluid are modeled using…

Fluid Dynamics · Physics 2023-07-18 Lahcen Akerkouch , Trung Bao Le

The linear viscoelastic behavior of the red blood cell membrane of mammal and human was studied in previous works proposing different experimental methods to determine their viscoelastic parameters. In the present work the nonlinear…

Chaotic Dynamics · Physics 2007-05-23 Horacio Castellini , Bibiana Riquelme , Patricia Foresto

Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…

Medical Physics · Physics 2023-09-28 Yu-Hsiang Chang , Yang-Hsien Lin , Kung-Bin Sung

The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may…

Cell Behavior · Quantitative Biology 2015-06-03 Maria Zeitz , Pierre Sens

We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between the {\it loading} (L) dynamics, following the…

Soft Condensed Matter · Physics 2021-06-01 Fabio Guglietta , Marek Behr , Giacomo Falcucci , Mauro Sbragaglia

The principle of optical trapping is conventionally based on the interaction of optical fields with linear induced polarizations. However, the optical force originating from the nonlinear polarization becomes significant when nonlinear…

Optics · Physics 2017-09-22 Liping Gong , Bing Gu , Guanghao Rui , Yiping Cui , Zhuqing Zhu , Qiwen Zhan

Motivated by the complex rheological behaviors observed in small/micro scale blood vessels, such as the Fahraeus effect, plasma-skimming, shear-thinning, etc., we develop a non-linear suspension model for blood. The viscosity is assumed to…

Fluid Dynamics · Physics 2018-12-26 Wei-Tao Wu , Nadine Aubry , James F. Antaki , Mehrdad Massoudi

Red blood cells (RBCs) are responsible for transporting oxygen and various metabolites to tissues and organs, as well as removing waste. Several cardiovascular diseases can impair these functions. For instance, in diabetes, increased RBC…

Biological Physics · Physics 2025-01-08 Mehdi Abbasi , Chaouqi Misbah

A transparent material exhibits ultra-fast optical nonlinearity and is subject to optical pressure if irradiated by a laser beam. However, the effect of nonlinearity on optical pressure is often overlooked, even if a nonlinear optical…

Optics · Physics 2015-06-19 Claudio Conti , Robert Boyd

It is shown that optomechanical forces can cause nonlinear self-channelling of light in a planar dual-slab waveguide. A system of two parallel silica nanowebs, spaced ~100 nm and supported inside a fibre capillary, is studied theoretically…

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