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Early and accessible detection of Alzheimer's disease (AD) remains a critical clinical challenge, and cube-copying tasks offer a simple yet informative assessment of visuospatial function. This work proposes a multimodal framework that…

Machine Learning · Computer Science 2025-12-19 Jaeho Yang , Kijung Yoon

Background:Speech patterns have emerged as potential diagnostic markers for conditions with varying etiologies. Machine learning (ML) presents an opportunity to harness these patterns for accurate disease diagnosis. Objective: This review…

Computation and Language · Computer Science 2025-03-10 Birger Moell , Fredrik Sand Aronsson , Per Östberg , Jonas Beskow

Dementia is a syndrome, generally of a chronic nature characterized by a deterioration in cognitive function, especially in the geriatric population and is severe enough to impact their daily activities. Early diagnosis of dementia is…

Audio and Speech Processing · Electrical Eng. & Systems 2020-07-21 Rupayan Chakraborty , Meghna Pandharipande , Chitralekha Bhat , Sunil Kumar Kopparapu

Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression…

Machine Learning · Computer Science 2018-12-07 Vipul Satone , Rachneet Kaur , Faraz Faghri , Mike A Nalls , Andrew B Singleton , Roy H Campbell

The detection of heterogeneous mental disorders based on brain readouts remains challenging due to the complexity of symptoms and the absence of reliable biomarkers. This paper introduces CAM (Cortical Anomaly Detection through Masked Image…

Image and Video Processing · Electrical Eng. & Systems 2024-02-14 Hao-Chun Yang , Ole Andreassen , Lars Tjelta Westlye , Andre F. Marquand , Christian F. Beckmann , Thomas Wolfers

Understanding the biological and behavioral heterogeneity underlying psychiatric disorders is critical for advancing precision diagnosis, treatment, and prevention. This paper addresses the scientific question of how multimodal data,…

Methodology · Statistics 2025-11-10 Yinjun Zhao , Yuanjia Wang , Ying LIu

While the number of children with diagnosed autism spectrum disorder (ASD) continues to rise from year to year, there is still no universal approach to autism diagnosis and treatment. A great variety of different tools and approaches for…

Human-Computer Interaction · Computer Science 2020-08-25 Anna Solovyova , Sergiy Danylov , Shpenkov Oleksii , Aleksandr Kravchenko

Radiomics with deep learning models have become popular in computer-aided diagnosis and have outperformed human experts on many clinical tasks. Specifically, radiomic models based on artificial intelligence (AI) are using medical data…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Ahmad Chaddad , Jiali li , Qizong Lu , Yujie Li , Idowu Paul Okuwobi , Camel Tanougast , Christian Desrosiers , Tamim Niazi

Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the…

Machine Learning · Computer Science 2022-04-29 Houliang Zhou , Lifang He , Yu Zhang , Li Shen , Brian Chen

Alzheimer's disease (AD) is the most common form of dementia, which causes problems with memory, thinking and behavior. Growing evidence has shown that the brain connectivity network experiences alterations for such a complex disease.…

Methodology · Statistics 2020-05-29 Chen Hao , Guo Ying , He Yong , Ji Jiadong , Liu Lei , Shi Yufeng , Wang Yikai , Yu Long , Zhang Xinsheng

Mental health conditions cause a great deal of distress or impairment; depression alone will affect 11% of the world's population. The application of Artificial Intelligence (AI) and big-data technologies to mental health has great…

Alzheimer's disease (AD) is an irreversible, progressive neuro degenerative disorder that slowly destroys memory and thinking skills and eventually, the ability to carry out the simplest tasks. In this paper, a deep neural network based…

Image and Video Processing · Electrical Eng. & Systems 2021-05-17 Manu Subramoniam , Aparna T. R. , Anurenjan P. R. , Sreeni K. G

Speech-based automatic detection of Alzheimer's disease (AD) and depression has attracted increased attention. Confidence estimation is crucial for a trust-worthy automatic diagnostic system which informs the clinician about the confidence…

Computation and Language · Computer Science 2024-09-10 Wen Wu , Chao Zhang , Philip C. Woodland

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical brain maturation. However, the adaptation of transfer learning paradigms in machine learning for ASD research remains notably limited. In this study,…

Machine Learning · Computer Science 2025-09-16 Kush Gupta , Amir Aly , Emmanuel Ifeachor , Rohit Shankar

Recent advances in general-purpose AI systems with attention-based transformers offer a potential window into how the neocortex and cerebellum, despite their relatively uniform circuit architectures, give rise to diverse functions and,…

Neurons and Cognition · Quantitative Biology 2025-12-03 Shogo Ohmae , Keiko Ohmae

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Early and precise diagnosis of AD is crucial for timely intervention and treatment planning to alleviate the progressive neurodegeneration. However, most…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Wenlong Hou , Guangqian Yang , Ye Du , Yeung Lau , Lihao Liu , Junjun He , Ling Long , Shujun Wang

Alzheimer's disease (AD) is a neurodegenerative disease known to affect brain functional connectivity (FC). Linear FC measures have been applied to study the differences in AD by splitting neurophysiological signals such as…

Neurons and Cognition · Quantitative Biology 2022-06-14 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

Purpose: This study investigates whether a machine-learning-based system can predict the rate of cognitive decline in mildly cognitively impaired patients by processing only the clinical and imaging data collected at the initial visit.…

Quantitative Methods · Quantitative Biology 2020-10-07 Sema Candemir , Xuan V. Nguyen , Luciano M. Prevedello , Matthew T. Bigelow , Richard D. White , Barbaros S. Erdal

Automated Alzheimer's Disease (AD) screening has predominantly followed the inductive paradigm of pattern recognition, which directly maps the input signal to the outcome label. This paradigm sacrifices construct validity of clinical…

Multiagent Systems · Computer Science 2026-03-19 Jiawen Kang , Kun Li , Dongrui Han , Jinchao Li , Junan Li , Lingwei Meng , Xixin Wu , Helen Meng

Existing research has shown the potential of classifying Alzheimers Disease (AD) from eye-tracking (ET) data with classifiers that rely on task-specific engineered features. In this paper, we investigate whether we can improve on existing…

Computer Vision and Pattern Recognition · Computer Science 2023-09-25 Harshinee Sriram , Cristina Conati , Thalia Field
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