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We apply three optical coherence tomography (OCT) image analysis techniques to extract morphometric information from OCT images obtained on peripheral nerves of rat. The accuracy of each technique is evaluated against histological…

Tissues and Organs · Quantitative Biology 2019-01-09 J. Hope , B. Brauer , S. Amirapu , A. McDaid , F. Vanholsbeeck

Advances in optical coherence tomography (OCT) have enabled noninvasive imaging of substructures of the human retina with high spatial resolution. OCT examinations are now a standard procedure in clinics and an integral part of ophthalmic…

Human-Computer Interaction · Computer Science 2022-12-22 Martin Röhlig , Oliver Stachs , Heidrun Schumann

Optical coherence tomography (OCT) is a non-invasive 3D modality widely used in ophthalmology for imaging the retina. Achieving automated, anatomically coherent retinal layer segmentation on OCT is important for the detection and monitoring…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Botond Fazekas , Guilherme Aresta , Dmitrii Lachinov , Sophie Riedl , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunovic

Due to its noninvasive character, optical coherence tomography (OCT) has become a popular diagnostic method in clinical settings. However, the low-coherence interferometric imaging procedure is inevitably contaminated by heavy speckle…

Image and Video Processing · Electrical Eng. & Systems 2020-07-08 Yongqiang Huang , Wenjun Xia , Zexin Lu , Yan Liu , Hu Chen , Jiliu Zhou , Leyuan Fang , Yi Zhang

Purpose: Middle ear infection is the most prevalent inflammatory disease, especially among the pediatric population. Current diagnostic methods are subjective and depend on visual cues from an otoscope, which is limited for otologists to…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Peng Liu , Jonas Golde , Joseph Morgenstern , Sebastian Bodenstedt , Chenpan Li , Yujia Hu , Zhaoyu Chen , Edmund Koch , Marcus Neudert , Stefanie Speidel

Using spectrally correlated photon pairs instead of classical laser light and coincidence detection instead of light intensity detection, Quantum Optical Coherence Tomography (Q-OCT) outperforms classical OCT in several experimental terms.…

Quantum Physics · Physics 2025-10-06 Sylwia M. Kolenderska , Crislane Vieira de Brito , Piotr Kolenderski

Ultrabroadband frequency combs coherently unite distant portions of the electromagnetic spectrum. They underpin discoveries in ultrafast science and serve as the building blocks of modern photonic technologies. Despite tremendous progress…

We present an experimental demonstration of quantum optical coherence tomography (QOCT). The technique makes use of an entangled twin-photon light source to carry out axial optical sectioning. QOCT is compared to conventional optical…

Quantum Physics · Physics 2019-10-18 Magued B. Nasr , Bahaa E. A. Saleh , Alexander V. Sergienko , Malvin C. Teich

Optical frequency combs are indispensable links between the optical and microwave domains, enabling a wide range of applications including precision spectroscopy, ultrastable frequency generation, and timekeeping. Chip-scale integration…

Optics · Physics 2024-02-20 Yunxiang Song , Yaowen Hu , Marko Lončar , Kiyoul Yang

A device based on Polarization sensitive optical coherence tomography is developed to monitor blood glucose levels in human subjects. The device was initially tested with tissue phantom. The measurements with human subjects for various…

Biological Physics · Physics 2015-06-04 Jitendra Solanki , OM Prakash Choudhury , Pratima Sen , Joseph Thomas Andrews

Optical Projection Tomography (OPT) is a powerful tool for 3D imaging of mesoscopic samples, thus of great importance to image whole organs for the study of various disease models in life sciences. OPT is able to achieve resolution at a few…

We review mathematical models describing how Optical Coherence Tomography works. Hereby, we focus on models based on Maxwell's equations and their simplifications. We highlight especially the effects of different modeling assumptions for…

Optics · Physics 2025-03-25 Peter Elbau , Leonidas Mindrinos , Leopold Veselka

Optical Deflectometric Tomography (ODT) provides an accurate characterization of transparent materials whose complex surfaces present a real challenge for manufacture and control. In ODT, the refractive index map (RIM) of a transparent…

Computer Vision and Pattern Recognition · Computer Science 2013-10-31 Adriana Gonzalez , Laurent Jacques , Christophe De Vleeschouwer , Philippe Antoine

Large-volume optical coherence tomography (OCT)-setups employ scanning mirrors and suffer from non-linear geometric distortion artifacts in which the degree of distortion is determined by the maximum angles over which the mirrors rotate. In…

Dispersion is a common phenomenon in optics due to the frequency dependence of the refractive index in polychromatic light. This issue, if left untreated in optical coherence tomography (OCT) imaging, leads to signal broadening of the…

Image and Video Processing · Electrical Eng. & Systems 2022-01-03 Shangbang Luo , Guy Holland , Eric Mikula , Samantha Bradford , Reza Khazaeinezhad , James V Jester , Tibor Juhasz

We demonstrate a different scheme to perform optical sectioning of a sample based on the concept of induced coherence [Zou et al., Phys. Rev. Lett. 67, 318 (1991)]. This can be viewed as a different type of optical coherence tomography…

Quantum Physics · Physics 2018-02-19 Adam Vallés , Gerard Jiménez , Luis José Salazar-Serrano , Juan P. Torres

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

Non-destructive testing (NDT) is crucial for ensuring product quality and safety across various industries. Conventional methods such as ultrasonic, terahertz, and X-ray imaging have limitations in terms of probe-contact requirement, depth…

Optical frequency comb, as a spectrum made of discrete and equally spaced spectral lines, is a light source with essential applications in modern technology. Cavity optomechanical systems were found to be a feasible candidate for realizing…

Optics · Physics 2024-08-13 Xin Gu , Jinlian Zhang , Shulin Ding , Xiaoshun Jiang , Bing He , Qing Lin

Spatial resolution in optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its…

Optics · Physics 2021-10-22 Nichaluk Leartprapun , Steven G. Adie
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