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Until recently, transcriptomics was limited to bulk RNA sequencing, obscuring the underlying expression patterns of individual cells in favor of a global average. Thanks to technological advances, we can now profile gene expression across…

Quantitative Methods · Quantitative Biology 2018-11-30 Miriam Shiffman , William T. Stephenson , Geoffrey Schiebinger , Jonathan Huggins , Trevor Campbell , Aviv Regev , Tamara Broderick

In order to survive, reproduce and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Aleksandra M. Walczak , William Bialek

This work deals with the reconstruction of dynamic images that incorporate characteristic dynamics in certain subregions, as arising for the kinetics of many tracers in emission tomography (SPECT, PET). We make use of a basis function…

Numerical Analysis · Mathematics 2016-08-24 Martin Burger , Carolin Rossmanith , Xiaoqun Zhang

We propose a physics-aware Consistency Training (CT) method that accelerates sampling in Diffusion Models with physical constraints. Our approach leverages a two-stage strategy: (1) learning the noise-to-data mapping via CT, and (2)…

Machine Learning · Computer Science 2025-02-12 Che-Chia Chang , Chen-Yang Dai , Te-Sheng Lin , Ming-Chih Lai , Chieh-Hsin Lai

The state space dynamics representation is the most general approach for nonlinear systems and often chosen for system identification. During training, the state trajectory can deform significantly leading to poor data coverage of the state…

Machine Learning · Computer Science 2025-07-11 Hermann Klein , Max Heinz Herkersdorf , Oliver Nelles

Analyzing the dynamic changes of cellular morphology is important for understanding the various functions and characteristics of live cells, including stem cells and metastatic cancer cells. To this end, we need to track all points on the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Junbong Jang , Kwonmoo Lee , Tae-Kyun Kim

This paper addresses the problem of recovering tracer kinetic parameters from multi-region measurement data in quantitative PET imaging using the reversible two tissue compartment model. Its main result is an extension of our previous work…

Optimization and Control · Mathematics 2025-04-15 Martin Holler , Erion Morina , Georg Schramm

All-in-one image restoration tackles different types of degradations with a unified model instead of having task-specific, non-generic models for each degradation. The requirement to tackle multiple degradations using the same model can…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Akshay Dudhane , Omkar Thawakar , Syed Waqas Zamir , Salman Khan , Fahad Shahbaz Khan , Ming-Hsuan Yang

Deep image prior (DIP) has been successfully applied to positron emission tomography (PET) image restoration, enabling represent implicit prior using only convolutional neural network architecture without training dataset, whereas the…

Medical Physics · Physics 2024-04-23 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Keisuke Matsubara , Masanobu Ibaraki

Recent advances in MRI reconstruction have demonstrated remarkable success through deep learning-based models. However, most existing methods rely heavily on large-scale, task-specific datasets, making reconstruction in data-limited…

Computer Vision and Pattern Recognition · Computer Science 2025-02-20 Guoyao Shen , Yancheng Zhu , Mengyu Li , Ryan McNaughton , Hernan Jara , Sean B. Andersson , Chad W. Farris , Stephan Anderson , Xin Zhang

We introduce Dynamic Dropout, a novel regularization technique designed to enhance the training efficiency of Transformer models by dynamically adjusting the dropout rate based on training epochs or validation loss improvements. This…

Machine Learning · Computer Science 2024-11-06 Hanrui Yan , Dan Shao

A human watching a video of closely-packed cells can generally identify every individual cell, regardless of density and noise, but most currently-available cell-tracking software cannot. This is because the human brain automatically builds…

Cell Behavior · Quantitative Biology 2017-09-27 Huy Pham , Emile Ramez Shehada , Shawna Stahlheber , Wayne B. Hayes

In dynamic positron emission tomography (PET) reconstruction, the importance of leveraging the temporal dependence of the data has been well appreciated. Current deep-learning solutions can be categorized in two groups in the way the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Yubo Ye , Huafeng Liu , Linwei Wang

U-Net and its variants have been demonstrated to work sufficiently well in biological cell tracking and segmentation. However, these methods still suffer in the presence of complex processes such as collision of cells, mitosis and…

Image and Video Processing · Electrical Eng. & Systems 2019-10-22 Deepak K. Gupta , Nathan de Bruijn , Andreas Panteli , Efstratios Gavves

Positron emission tomography(PET) image reconstruction is an ill-posed inverse problem and suffers from high level of noise due to limited counts received. Recently deep neural networks especially convolutional neural networks(CNN) have…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Rui Hu , Huafeng Liu

The kernel reconstruction is a method that reduces noise in dynamic positron emission tomography (PET) by exploiting spatial correlations in the PET image. Although this method works well for large anatomical regions with relatively slow…

Medical Physics · Physics 2025-07-31 Alan Miranda , Steven Staelens

Randomly moving active particles can be herded into directed motion by asymmetric geometric structures. Although such a rectification process has been extensively studied due to its fundamental, biological, and technological relevance, a…

Soft Condensed Matter · Physics 2026-03-31 Satyam Anand , Xiaolei Ma , Shuo Guo , Stefano Martiniani , Xiang Cheng

Automated animal behavior analysis relies on long-term, interpretable individual trajectories; however, multi-animal tracking in space science experimental videos remains highly challenging due to weak appearance cues, low-quality imaging,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Jianing You , Han Wang , Kang Liu , Jiale Ding , Fengjie Chu , Zihan Guo , Shengyang Li

Kinect skeleton tracker is able to achieve considerable human body tracking performance in convenient and a low-cost manner. However, The tracker often captures unnatural human poses such as discontinuous and vibrated motions when…

Computer Vision and Pattern Recognition · Computer Science 2016-04-18 Youngbin Park , Sungphill Moon , Il Hong Suh

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Shaoyan Pan , Elham Abouei , Junbo Peng , Joshua Qian , Jacob F Wynne , Tonghe Wang , Chih-Wei Chang , Justin Roper , Jonathon A Nye , Hui Mao , Xiaofeng Yang