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Different cell types aggregate and sort into hierarchical architectures during the formation of animal tissues. The resulting spatial organization depends (in part) on the strength of adhesion of one cell type to itself relative to other…

Quantitative Methods · Quantitative Biology 2023-08-02 Dhananjay Bhaskar , William Y. Zhang , Alexandria Volkening , Björn Sandstede , Ian Y. Wong

In this paper, we apply persistent entropy, a novel topological statistic, for characterization of images of epithelial tissues. We have found out that persistent entropy is able to summarize topological and geometric information encoded by…

Image and Video Processing · Electrical Eng. & Systems 2021-05-19 N. Atienza , L. M. Escudero , M. J. Jimenez , M. Soriano-Trigueros

Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Interacting, self-propelled particles such as epithelial cells can dynamically self-organize into complex multicellular patterns, which are challenging to classify without a priori information. Classically, different phases and phase…

Quantitative Methods · Quantitative Biology 2021-01-19 Dhananjay Bhaskar , William Y. Zhang , Ian Y. Wong

We start with a simple introduction to topological data analysis where the most popular tool is called a persistent diagram. Briefly, a persistent diagram is a multiset of points in the plane describing the persistence of topological…

Statistics Theory · Mathematics 2017-06-28 Christophe Biscio , Jesper Møller

Topological data analysis (TDA) uses persistent homology to quantify loops and higher-dimensional holes in data, making it particularly relevant for examining the characteristics of images of cells in the field of cell biology. In the…

Methodology · Statistics 2024-05-06 Susan Glenn , Jessi Cisewski-Kehe , Jun Zhu , William M. Bement

Persistent homology provides information about the lifetime of homology classes along a filtration of cell complexes. Persistence barcode is a graphical representation of such information. A filtration might be determined by time in a set…

Computer Vision and Pattern Recognition · Computer Science 2018-01-04 Rocio Gonzalez-Diaz , Maria-Jose Jimenez , Belen Medrano

Topological data analysis (TDA) is a rising branch in modern applied mathematics. It extracts topological structures as features of a given space and uses these features to analyze digital data. Persistent homology, one of the central tools…

Algebraic Topology · Mathematics 2025-05-26 Chuan-Shen Hu

Persistent homology is a common technique in topological data analysis providing geometrical and topological information about the sample space. All this information, known as topological features, is summarized in persistence diagrams, and…

Methodology · Statistics 2022-04-05 Asael Fabian Martínez

This paper aims to discuss a method of quantifying the 'shape' of data, via a methodology called topological data analysis. The main tool within topological data analysis is persistent homology; this is a means of measuring the shape of…

Algebraic Topology · Mathematics 2022-09-14 Tristan Gowdridge , Nikolaos Devilis , Keith Worden

A topos theoretic generalisation of the category of sets allows for modelling spaces which vary according to time intervals. Persistent homology, or more generally, persistence is a central tool in topological data analysis, which examines…

Rings and Algebras · Mathematics 2015-06-23 João Pita Costa , Mikael Vejdemo Johansson , Primož Škraba

Finding an optimal parameter of a black-box function is important for searching stable material structures and finding optimal neural network structures, and Bayesian optimization algorithms are widely used for the purpose. However, most of…

Machine Learning · Computer Science 2019-02-27 Tatsuya Shiraishi , Tam Le , Hisashi Kashima , Makoto Yamada

This paper is a survey of persistent homology, primarily as it is used in topological data analysis. It includes the theory of persistence modules, as well as stability theorems for persistence barcodes, generalized persistence,…

Algebraic Topology · Mathematics 2020-04-03 Gunnar Carlsson

Topological data analysis provides a set of tools to uncover low-dimensional structure in noisy point clouds. Prominent amongst the tools is persistence homology, which summarizes birth-death times of homological features using data objects…

Methodology · Statistics 2024-02-05 James Matuk , Sebastian Kurtek , Karthik Bharath

Topological data analysis can extract effective information from higher-dimensional data. Its mathematical basis is persistent homology. The persistent homology can calculate topological features at different spatiotemporal scales of the…

Algebraic Topology · Mathematics 2023-09-29 Dinghua Shi , Zhifeng Chen , Chuang Ma , Guanrong Chen

One of the primary areas of interest in applied algebraic topology is persistent homology, and, more specifically, the persistence diagram. Persistence diagrams have also become objects of interest in topological data analysis. However,…

Methodology · Statistics 2018-04-06 Eric Berry , Yen-Chi Chen , Jessi Cisewski-Kehe , Brittany Terese Fasy

While branching network structures abound in nature, their objective analysis is more difficult than expected because existing quantitative methods often rely on the subjective judgment of branch structures. This problem is particularly…

Algebraic Topology · Mathematics 2024-02-13 Haruhisa Oda , Mayuko Kida , Yoichi Nakata , Hiroki Kurihara

We study distributions of persistent homology barcodes associated to taking subsamples of a fixed size from metric measure spaces. We show that such distributions provide robust invariants of metric measure spaces, and illustrate their use…

Computational Geometry · Computer Science 2014-01-20 Andrew J. Blumberg , Itamar Gal , Michael A. Mandell , Matthew Pancia

The geometry of neurons is known to be important for their functions. Hence, neurons are often classified by their morphology. Two recent methods, persistent homology and the topological morphology descriptor, assign a morphology descriptor…

Neurons and Cognition · Quantitative Biology 2022-04-08 David Beers , Despoina Goniotaki , Diane P. Hanger , Alain Goriely , Heather A. Harrington

In medical image analysis, feature engineering plays an important role in the design and performance of machine learning models. Persistent homology (PH), from the field of topological data analysis (TDA), demonstrates robustness and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-05 Dashti A. Ali , Richard K. G. Do , William R. Jarnagin , Aras T. Asaad , Amber L. Simpson
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