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The epidemic spreading has been studied for years by applying the mean-field approach in both homogeneous case, where each node may get infected by an infected neighbor with the same rate, and heterogeneous case, where the infection rates…

Physics and Society · Physics 2016-09-06 Bo Qu , Huijuan Wang

This article is devoted to the analysis of a particle system model for epidemics among a finite population with susceptible, infective and removed individuals (SIR). The infection mechanism depends on the relative distance between…

Probability · Mathematics 2020-03-10 Monia Capanna

We study the relative importance of two key control measures for epidemic spreading: endogenous social self-distancing and exogenous imposed quarantine. We use the framework of adaptive networks, moment-closure, and ordinary differential…

Populations and Evolution · Quantitative Biology 2020-10-22 Leonhard Horstmeyer , Christian Kuehn , Stefan Thurner

Understanding how to effectively control an epidemic spreading on a network is a problem of paramount importance for the scientific community. The ongoing COVID-19 pandemic has highlighted the need for policies that mitigate the spread,…

Populations and Evolution · Quantitative Biology 2021-09-14 Carlo Cenedese , Lorenzo Zino , Michele Cucuzzella , Ming Cao

The coronavirus disease 2019 (COVID-19) pandemic is changing and impacting lives on a global scale. In this paper, we introduce a mean-field game model in controlling the propagation of epidemics on a spatial domain. The control variable,…

Optimization and Control · Mathematics 2020-11-12 Wonjun Lee , Siting Liu , Hamidou Tembine , Wuchen Li , Stanley Osher

We study the influence of heterogeneous mobility patterns in a population on the SIS epidemic model. In particular, we consider a patchy environment in which each patch comprises individuals belonging the different classes, e.g.,…

Systems and Control · Electrical Eng. & Systems 2020-03-31 Vishal Abhishek , Vaibhav Srivastava

Infectious disease superspreading caused by heterogeneity in contact behavior has been observed to be an important determinant of epidemic dynamics and size in both empirical and theoretical settings. However, it has also been observed that…

Populations and Evolution · Quantitative Biology 2026-01-27 Ari S. Freedman , Bjarke F. Nielsen , Maximillian M. Nguyen , Laurent Hébert-Dufresne , Simon A. Levin

We study a coupled epidemic-mobility model in which, at each time, individuals move in a network of spatially-distributed regions (sub-populations) according to a Continuous Time Markov Chain (CTMC) and subsequently interact with the local…

Systems and Control · Electrical Eng. & Systems 2019-09-30 Vishal Abhishek , Vaibhav Srivastava

Contagious diseases can spread quickly in human populations, either through airborne transmission or if some other spreading vectors are abundantly accessible. They can be particularly devastating if the impact on individuals' health has…

Physics and Society · Physics 2022-07-20 Bram A. Siebert , James P. Gleeson , M. Asllani

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

Systems and Control · Electrical Eng. & Systems 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

We consider the problem of controlling an SIR-model epidemic by temporarily reducing the rate of contact within a population. The control takes the form of a multiplicative reduction in the contact rate of infectious individuals. The…

Optimization and Control · Mathematics 2021-06-29 David I. Ketcheson

We study the critical effect of an intermittent social distancing strategy on the propagation of epidemics in adaptive complex networks. We characterize the effect of our strategy in the framework of the susceptible-infected-recovered…

Physics and Society · Physics 2012-04-02 L. D. Valdez , P. A. Macri , L. A. Braunstein

We derive a Maximum Principle for optimal control problems with constraints given by the coupling of a system of ODEs and a PDE of Vlasov-type. Such problems arise naturally as ${\Gamma}$-limits of optimal control problems subject to ODE…

Optimization and Control · Mathematics 2015-04-10 Mattia Bongini , Massimo Fornasier , Francesco Rossi , Francesco Solombrino

We consider a model for an epidemic in a population that occupies geographically distinct locations. The disease is spread within subpopulations by contacts between infective and susceptible individuals, and is spread between subpopulations…

Probability · Mathematics 2016-02-15 R. McVinish , P. K. Pollett , A. Shausan

Incorporating social interactions is essential to an accurate modeling of epidemic spreading. This work proposes a novel local mean-field density functional theory model by using the sum-of-exponential approximation of convolution kernels…

Physics and Society · Physics 2025-09-09 Ziheng Xu , Shenggao Zhou

Higher-order interactions play an important role in complex contagion processes. Mean-field approximations have been used to characterize the onset of spreading in the presence of group interactions. However, individual-based mean-field…

Physics and Society · Physics 2024-10-02 Federico Malizia , Luca Gallo , Mattia Frasca , István Z. Kiss , Vito Latora , Giovanni Russo

In this paper, we present a discrete-time networked SEIR model using population flow, its derivation, and assumptions under which this model is well defined. We identify properties of the system's equilibria, namely the healthy states. We…

Systems and Control · Electrical Eng. & Systems 2021-04-16 Brooks Butler , Ciyuan Zhang , Ian Walter , Nishant Nair , Raphael Stern , Philip E. Paré

We develop a feedback control method for networked epidemic spreading processes. In contrast to most prior works which consider mean field, open-loop control schemes, the present work develops a novel framework for feedback control of…

Optimization and Control · Mathematics 2017-03-23 Nicholas J. Watkins , Cameron Nowzari , George J. Pappas

Metapopulation models have been a powerful tool for both theorizing and simulating epidemic dynamics. In a metapopulation model, one considers a network composed of subpopulations and their pairwise connections, and individuals are assumed…

Physics and Society · Physics 2021-12-28 Lingqi Meng , Naoki Masuda

In this paper, we investigate a parabolic-ODE SIS epidemic model with no-flux boundary conditions in a heterogeneous environment. The model incorporates a saturated infection mechanism \({SI}/(m(x) + S + I)\) with \(m \geq,\,\not\equiv 0\).…

Analysis of PDEs · Mathematics 2025-03-28 Rui Peng , Rachidi Salako , Yixiang Wu