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The Segment Anything Model (SAM) marks a significant advancement in segmentation models, offering robust zero-shot abilities and dynamic prompting. However, existing medical SAMs are not suitable for the multi-scale nature of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hong Liu , Haosen Yang , Paul J. van Diest , Josien P. W. Pluim , Mitko Veta

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

Quantitative Methods · Quantitative Biology 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Thyroid cancer is the most common endocrine malignancy, and accurately distinguishing between benign and malignant thyroid tumors is crucial for developing effective treatment plans in clinical practice. Pathologically, thyroid tumors pose…

Image and Video Processing · Electrical Eng. & Systems 2024-01-04 Jia Dong , Yao Yao , Yang Dong , Hui Ma

Tumor segmentation stands as a pivotal task in cancer diagnosis. Given the immense dimensions of whole slide images (WSI) in histology, deep learning approaches for WSI classification mainly operate at patch-wise or superpixel-wise level.…

Computer Vision and Pattern Recognition · Computer Science 2024-02-22 Huaqian Wu , Clara Brémond-Martin , Kévin Bouaou , Cédric Clouchoux

Segmentation of nodules in thyroid ultrasound imaging plays a crucial role in the detection and treatment of thyroid cancer. However, owing to the diversity of scanner vendors and imaging protocols in different hospitals, the automatic…

Image and Video Processing · Electrical Eng. & Systems 2024-01-23 Xuewei Li , Yaqiao Zhu , Jie Gao , Xi Wei , Ruixuan Zhang , Yuan Tian , ZhiQiang Liu

Accurate survival prediction from histopathology whole-slide images (WSIs) remains challenging due to their gigapixel resolution, strong spatial heterogeneity, and complex survival distributions. We introduce a comprehensive computational…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Ardhendu Sekhar , Vasu Soni , Keshav Aske , Shivam Madnoorkar , Pranav Jeevan , Amit Sethi

Whole Slide Imaging (WSI) has become an important topic during the last decade. Even though significant progress in both medical image processing and computational resources has been achieved, there are still problems in WSI that need to be…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Wafa Chenni , Habib Herbi , Morteza Babaie , H. R. Tizhoosh

In digital pathology, the traditional method for deep learning-based image segmentation typically involves a two-stage process: initially segmenting high-resolution whole slide images (WSI) into smaller patches (e.g., 256x256, 512x512,…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Yucheng Tang , Yufan He , Vishwesh Nath , Pengfeig Guo , Ruining Deng , Tianyuan Yao , Quan Liu , Can Cui , Mengmeng Yin , Ziyue Xu , Holger Roth , Daguang Xu , Haichun Yang , Yuankai Huo

Convolutional neural networks, the state of the art for image segmentation, have been successfully applied to histology images by many computational researchers. However, the translatability of this technology to clinicians and biological…

Image and Video Processing · Electrical Eng. & Systems 2021-01-19 Brendon Lutnick , David Manthey , Pinaki Sarder

Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Ravi Kant Gupta , Shounak Das , Amit Sethi

Whole-slide images (WSIs) are fundamental for computational pathology, where accurate lesion segmentation is critical for clinical decision making. Existing methods partition WSIs into discrete patches, disrupting spatial continuity and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Yunheng Wu , Wenqi Huang , Liangyi Wang , Masahiro Oda , Yuichiro Hayashi , Daniel Rueckert , Kensaku Mori

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

The last decade has seen significant advances in computer-aided diagnostics for cytological screening, mainly through the improvement and integration of scanning techniques such as whole slide imaging (WSI) and the combination with deep…

Signal Processing · Electrical Eng. & Systems 2026-01-23 Philip Groult , Julia D. Sistermanns , Ellen Emken , Oliver Hayden , Wolfgang Utschick

The increasing prevalence of thyroid cancer globally has led to the development of various computer-aided detection methods. Accurate segmentation of thyroid nodules is a critical first step in the development of AI-assisted clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Mahmoud El Hussieni

Deep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate labeling. Additionally, these methods often…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Wangang Cheng , Guanghua He , Keli Hu , Mingyu Fang , Liang Dong , Zhong Li , Hancan Zhu

Automatic outlining of different tissue types in digitized histological specimen provides a basis for follow-up analyses and can potentially guide subsequent medical decisions. The immense size of whole-slide-images (WSI), however, poses a…

Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 André Pedersen , Erik Smistad , Tor V. Rise , Vibeke G. Dale , Henrik S. Pettersen , Tor-Arne S. Nordmo , David Bouget , Ingerid Reinertsen , Marit Valla

Whole-slide image analysis is essential for diagnostic tasks in pathology, yet existing deep learning methods primarily rely on flat classification, ignoring hierarchical relationships among class labels. In this study, we propose HiClass,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Keunho Byeon , Jinsol Song , Seong Min Hong , Yosep Chong , Jin Tae Kwak

Accurate liver segmentation in multi-phase MRI is vital for liver fibrosis assessment, yet labeled data is often scarce and unevenly distributed across imaging modalities and vendor systems. We propose a label-efficient segmentation…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Quang-Khai Bui-Tran , Minh-Toan Dinh , Thanh-Huy Nguyen , Ba-Thinh Lam , Mai-Anh Vu , Ulas Bagci

Accurate detection of thyroid lesions is a critical aspect of computer-aided diagnosis. However, most existing detection methods perform only one feature extraction process and then fuse multi-scale features, which can be affected by noise…

Computer Vision and Pattern Recognition · Computer Science 2023-05-25 Lingtao Wang , Jianrui Ding , Fenghe Tang , Chunping Ning