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Understanding the (de)mixing behavior of multicomponent lipid bilayers is an important step towards unraveling the nature of spatial composition heterogeneities in cellular membranes and their role in biological function. We use…

Soft Condensed Matter · Physics 2018-05-17 Shushan He , Lutz Maibaum

Liquid mixtures can separate into phases with distinct composition. This phenomenon has recently come back to prominence due to its role in complex biological liquids, such as the cytoplasm, which contain thousands of components. For simple…

Statistical Mechanics · Physics 2025-12-11 Rodrigo Braz Teixeira , Izaak Neri , Pablo Sartori

We study the theoretical phase behavior of an asymmetric binary mixture of hard spheres, of which the smaller component is monodisperse and the larger component is polydisperse. The interactions are modeled in terms of the second virial…

Statistical Mechanics · Physics 2019-12-09 Luka Sturtewagen , Erik van der Linden

Computational determination of the equilibrium state of heterogeneous phospholipid mem-branes is a significant challenge. We wish to explore the rich phase diagram of these multi-component systems. However, the diffusion and mixing times in…

Biological Physics · Physics 2020-10-28 Yevhen K. Cherniavskyi , Arman Fathizadeh , Ron Elber , D. Peter Tieleman

As a generic model system of an asymmetric binary fluid mixture, hexadecane dissolved in carbon dioxide is considered, using a coarse-grained bead-spring model for the short polymer, and a simple spherical particle with Lennard-Jones…

Soft Condensed Matter · Physics 2009-11-13 K. Bucior , L. Yelash , K. Binder

A multi-phase-field model for the description of the discontinuous precipitation reaction is formulated which takes into account surface diffusion along grain boundaries and interfaces as well as volume diffusion. Simulations reveal that…

Materials Science · Physics 2008-09-04 Lynda Amirouche , Mathis Plapp

Spontaneous phase separation, or demixing, is important in biological phenomena such as cell sorting. In particle-based models, an open question is whether differences in diffusivity can drive such demixing. While…

Soft Condensed Matter · Physics 2023-07-10 Erin McCarthy , Ojan Damavandi , Raj Kumar Manna , M. Lisa Manning

Differences in activities in colloidal particles are sufficient to drive phase separation between active and passive (or less active) particles, even if they have only excluded volume interactions. In this paper, we study the phase…

Soft Condensed Matter · Physics 2020-05-27 Efe Ilker , Jean-François Joanny

A class of models of driven diffusive systems which is shown to exhibit phase separation in $d=1$ dimensions is introduced. Unlike all previously studied models exhibiting similar phenomena, here the phase separated state is fluctuating in…

Statistical Mechanics · Physics 2009-11-07 Y. Kafri , E. Levine , D. Mukamel , G. M. Schutz , R. D. Willmann

We introduce a coupled Cahn-Hilliard Navier-Stokes model that governs the two-phase dynamics of a system that consists of a fluid and a solid phase and prove its thermodynamic consistency. Moreover, we present an associated fully-discrete…

Numerical Analysis · Mathematics 2026-01-15 Cedric Riethmüller , Lars von Wolff , Dominik Göddeke , Christian Rohde

We present results from a comprehensive numerical study of {\it morphological phase separation} (MPS) in unstable thin liquid films on a 2-dimensional substrate. We study the quantitative properties of the evolution morphology via several…

Soft Condensed Matter · Physics 2017-09-13 Prabhat K. Jaiswal , Manish Vashishtha , Sanjay Puri , Rajesh Khanna

A theoretical scheme for the calculation of the full phase diagram (including cloud and shadow curves, binodals and distribution functions of the coexisting phases) for colloid-polymer mixtures with polymer chain length polydispersity and…

Soft Condensed Matter · Physics 2009-11-13 Y. V. Kalyuzhnyi , P. T. Cummings

Within this work, we develop a phase-field description for simulating fractures in incompressible materials. Standard formulations are subject to volume-locking when the solid is (nearly) incompressible. We propose an approach that builds…

Numerical Analysis · Mathematics 2024-12-20 Katrin Mang , Thomas Wick , Winnifried Wollner

Liquid-liquid phase separation is key to understanding aqueous two-phase systems (ATPS) arising throughout cell biology, medical science, and the pharmaceutical industry. Controlling the detailed morphology of phase-separating compound…

Soft Condensed Matter · Physics 2023-10-27 Eric W. Hester , Sean P. Carney , Vishwesh Shah , Alyssa Arnheim , Bena Patel , Dino Di Carlo , Andrea L. Bertozzi

A thermodynamic approach to rapid phase transformations within a diffuse interface in a binary system is developed. Assuming an extended set of independent thermodynamic variables formed by the union of the classic set of slow variables and…

Materials Science · Physics 2009-11-10 Peter Galenko , David Jou

We review understanding of kinetics of fluid phase separation in various space dimensions. Morphological differences, percolating or disconnected, based on overall composition in a binary liquid or density in a vapor-liquid system, have…

Statistical Mechanics · Physics 2020-06-05 Subir K. Das , Sutapa Roy , Jiarul Midya

We study dynamic heterogeneities in a model glass-former whose overlap with a reference configuration is constrained to a fixed value. The system phase-separates into regions of small and large overlap, so that dynamical correlations remain…

Disordered Systems and Neural Networks · Physics 2012-07-19 C. Cammarota , A. Cavagna , I. Giardina , G. Gradenigo , T. S. Grigera , G. Parisi , P. Verrocchio

A phase-separation front will leave in its wake a phase-separated morphology that differs markedly from homogeneous phase-separation morphologies. For a purely diffusive system such a front, moving with constant velocity, will generate very…

Soft Condensed Matter · Physics 2013-05-30 E. M. Foard , A. J. Wagner

Liquid-liquid phase separation plays a major role in the formation and maintenance of various membrane-less subcellular structures in the cytoplasm and nucleus of cells. Biological condensates contain enhanced concentrations of proteins and…

Soft Condensed Matter · Physics 2023-10-03 Paul C Bressloff

The phase behavior is investigated for systems composed of a large number of macromolecular components N, with N greater or equal to 2. Liquid-liquid phase separation is modelled using a virial expansion up to the second order of the…

Soft Condensed Matter · Physics 2024-05-29 Arjen Bot , Erik van der Linden , Paul Venema