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A free boundary value problem related to the genesis of multispecies granular biofilms is presented. The granular biofilm is modelled as a spherical free boundary domain with radial symmetry. The proposed model is conceived in the framework…

Analysis of PDEs · Mathematics 2023-01-31 F. Russo , M. R. Mattei , A. Tenore , B. D'Acunto , V. Luongo , L. Frunzo

In this paper we focus the attention on free boundary problems ruled by partial differential equations with nonstandard growth, presenting in particular some recent results. The interest in these problems stems from the diverse applications…

Analysis of PDEs · Mathematics 2026-03-17 Fausto Ferrari , Monica Jacob , Claudia Lederman

In this paper, we study a free boundary problem for a class of nonlinear nonautonomous size structured population model. Using the comparison principle and upper lower solution methods, we establish the existence of the solution for such…

Analysis of PDEs · Mathematics 2017-11-10 Wenbin Lv , Shaohua Wu

We introduce a free boundary model to example the effect of vesicle transport onto neurite growth. It consists of systems of drift-diffusion equations describing the evolution of the density of antero- and retrograde vesicles in each…

Analysis of PDEs · Mathematics 2025-11-26 Greta Marino , Jan-Frederik Pietschmann , Max Winkler

In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…

Analysis of PDEs · Mathematics 2026-03-05 Maeve Wildes

This paper concerns the theoretical and numerical analysis of a free boundary problem for the Laplace equation, with a curvature condition on the free boundary. This boundary is described as the graph of a function, and contact angles are…

Numerical Analysis · Mathematics 2017-07-04 Ivan Fumagalli

In this paper we consider a free boundary tumor growth model with a time delay in cell proliferation and study how time delay affects the stability and the size of the tumor. The model is a coupled system of an elliptic equation, a…

Analysis of PDEs · Mathematics 2019-08-20 Xinyue Evelyn Zhao , Bei Hu

In this paper, we investigate the tumor instability by employing both analytical and numerical techniques to validate previous results and extend the analytical findings presented in a prior study by Feng et al 2023. Building upon the…

Analysis of PDEs · Mathematics 2024-01-11 Jian-Guo Liu , Thomas Witelski , Xiaoqian Xu , Jiaqi Zhang

In this paper we study the two-phase Bernoulli type free boundary problem arising from the minimization of the functional $$ J(u):=\int_{\Omega}|\nabla u|^p +\lambda_+^p\,\chi_{\{u>0\}} +\lambda_-^p\,\chi_{\{u\le 0\}}, \quad 1<p<\infty. $$…

Analysis of PDEs · Mathematics 2015-12-11 Serena Dipierro , Aram L. Karakhanyan

We consider a Hele-Shaw model that describes tumor growth subject to nutrient supply. The model is derived by taking the incompressible limit of porous medium type equations, and the boundary instability of this model was recently studied…

Analysis of PDEs · Mathematics 2025-05-13 Yu Feng , Qingyou He , Jian-Guo Liu , Zhennan Zhou

In this work, we derive asymptotic interface models for an elastic Muskat free boundary problem describing Darcy flow beneath an elastic membrane. In a weakly nonlinear regime of small interface steepness, we obtain nonlocal evolution…

Analysis of PDEs · Mathematics 2026-02-12 Diego Alonso-Orán , Rafael Granero-Belinchón

Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

We consider a one-dimensional free boundary problem governed by a nonlinear diffusion - convection equation with a Neumann condition at fixed face $x=0$, which is variable in time and a like Stefan convective condition on the free boundary.…

Analysis of PDEs · Mathematics 2024-10-07 Adriana C. Briozzo

In this paper a macroscopic model of tumor cord growth is developed, relying on the mathematical theory of deformable porous media. Tumor is modeled as a saturated mixture of proliferating cells, extracellular fluid and extracellular…

Mathematical Physics · Physics 2010-11-09 Andrea Tosin

We prove an existence result for a free boundary problem inspired by the modelization of accretive growth. The growth process is formulated through a level-set approach, leading to a boundary-value problem for a Hamilton-Jacobi equation…

Analysis of PDEs · Mathematics 2026-02-17 Ulisse Stefanelli

This paper provides a unified mathematical analysis of a family of non-local diffuse interface models for tumor growth describing evolutions driven by long-range interactions. These integro-partial differential equations model cell-to-cell…

Analysis of PDEs · Mathematics 2021-07-07 Luca Scarpa , Andrea Signori

We study the regularity of the "free surface" in boundary obstacle problems. We show that near a non-degenerate point the free boundary is a $C^{1,\alpha}$ $(n-2)$-dimensional surface in $\real^{n-1}$.

Analysis of PDEs · Mathematics 2007-05-23 I. Athanasopoulos , L. A. Caffarelli , S. Salsa

In this work we will study the dynamics of a thin layer of a viscous fluid which is embedded in the interior of another viscous fluid. The resulting flow can be approximated by means of the solutions of a free boundary problem for the…

Analysis of PDEs · Mathematics 2020-10-30 Tania Pernas-Castaño , Juan J. L. Velázquez

We propose a model for describing the growth on an untreated tumor, which is characterized in a simple way by a minimal number of parameters with a well-defined physical interpretation. The model is motivated by invoking the Master Equation…

Populations and Evolution · Quantitative Biology 2007-05-23 José F. Nieves , Marcelo R. Ubriaco

Tumor growth has long been a target of investigation within the context of mathematical and computer modelling. The objective of this study is to propose and analyze a two-dimensional probabilistic cellular automata model to describe…

Tissues and Organs · Quantitative Biology 2009-11-13 E. A. Reis , L. B. L. Santos , S. T. R. Pinho