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Nuclear Magnetic Resonance (NMR) spectroscopy is the cornerstone of small-molecule structure elucidation. While deep learning has demonstrated significant potential in automating structure elucidation and spectral simulation, current…

Computational Engineering, Finance, and Science · Computer Science 2026-01-23 Zheng Fang , Chen Yang , Hai-tao Yu , Haoming Luo , Haitao He , Jiaqing Xie , Zhuo Yang , Jun Xia

Scanning probe microscopy using nitrogen vacancy (NV) centers in diamond has become a versatile tool with applications in physics, chemistry, life sciences and earth and planetary sciences. However, the fabrication of diamond scanning…

Mesoscale and Nanoscale Physics · Physics 2017-11-28 Tony X. Zhou , Rainer J. Stöhr , Amir Yacoby

Quantum sensors based on optically active defects in diamond such as the nitrogen vacancy (NV) centre represent a promising platform for nanoscale sensing and imaging of magnetic, electric, temperature and strain fields. Enhancing the…

Nitrogen-vacancy (NV) centers in diamond are a leading modality for magnetic sensing and imaging under ambient conditions. However, these sensors suffer from degraded performance due to paramagnetic impurities and regions of stress in the…

Quantum Physics · Physics 2024-04-22 Connor Roncaioli , Connor Hart , Ronald Walsworth , Donald P. Fahey

Sensitive nanoscale magnetic resonance imaging (MRI) of target spins using nitrogen-vacancy (NV) centers in diamond will require a quantitative understanding of dominant noise at the surface. We probe this noise by applying dynamical…

Mesoscale and Nanoscale Physics · Physics 2014-07-11 Bryan A. Myers , Matthieu C. Dartiailh , Kenichi Ohno , Ananda Das , David D. Awschalom , Ania C. Bleszynski Jayich

A diamond-based sensor utilizing nitrogen-vacancy (NV) center ensembles permits the analysis of micron-sized samples through NMR techniques at room temperature. Current efforts are directed towards extending the operating range of NV…

Quantum Physics · Physics 2024-10-07 P. Alsina-Bolívar , A. Biteri-Uribarren , C. Munuera-Javaloy , J. Casanova

The confluence of quantum physics and biology is driving a new generation of quantum-based sensing and imaging technology capable of harnessing the power of quantum effects to provide tools to understand the fundamental processes of life.…

Quantum Physics · Physics 2015-06-05 D. Maclaurin , L. T. Hall , A. M. Martin , L. C. L. Hollenberg

Magnetometers based on quantum mechanical processes enable high sensitivity and long-term stability without the need for re-calibration, but their integration into fieldable devices remains challenging. This paper presents a CMOS quantum…

Applied Physics · Physics 2020-07-23 Mohamed I. Ibrahim , Christopher Foy , Dirk R. Englund , Ruonan Han

Nitrogen-vacancy (NV) centers in diamond are a versatile quantum sensing platform for high sensitivity measurements of magnetic fields, temperature and strain with nanoscale spatial resolution. A common bottleneck is the analysis of…

In diamond, nitrogen defects like the substitutional nitrogen defect (Ns) or the nitrogen-vacancy-hydrogen complex (NVH) outnumber the nitrogen vacancy (NV) defect by at least one order of magnitude creating a dense spin bath. While neutral…

Nuclear Magnetic Resonance (NMR) spectroscopy is a crucial analytical technique used for molecular structure elucidation, with applications spanning chemistry, biology, materials science, and medicine. However, the frequency resolution of…

We describe a scanning device where a single spin is used as an ultrasensitive, nanoscale magnetic field sensor. As this "probe spin" we consider a single nitrogen-vacancy defect center in a diamond nanocrystal, attached to the tip of the…

Mesoscale and Nanoscale Physics · Physics 2008-09-23 C. L. Degen

Nuclear magnetic resonance (NMR) at the single-molecule level with atomic resolution holds transformative potential for structural biology and surface chemistry. Near-surface solid-state spin sensors with optical readout ability offer a…

Quantum Physics · Physics 2025-12-12 Yu Chen , Qi Zhang , Yuanhong Teng , Chihang Luo , Zhijie Li , Jinpeng Liu , Ya Wang , Fazhan Shi , Jiangfeng Du

The NV center in a diamond is a quantum sensor with exceptional quality for highly sensitive nanoscale analysis of NMR spectra and thermometry. In this study, we investigate nanoscale phase change detection of lipid bilayers utilizing…

The nitrogen-vacancy (NV) centre in diamond has emerged as a candidate to non-invasively hyperpolarise nuclear spins in molecular systems to improve the sensitivity of nuclear magnetic resonance (NMR) experiments. Several promising proof of…

Mesoscale and Nanoscale Physics · Physics 2021-05-26 A. J. Healey , L. T. Hall , G. A. L. White , T. Teraji , M. -A. Sani , F. Separovic , J. -P. Tetienne , L. C. L. Hollenberg

Optically active spin defects in solids offer promising platforms to investigate nuclear spin clusters with high sensitivity and atomic-site resolution. To leverage near-surface defects for molecular structure analysis in chemical and…

Sensitive Radio-Frequency (RF) magnetometers that can detect oscillating magnetic fields at the femtotesla level are needed for demanding applications such as Nuclear Quadrupole Resonance (NQR) spectroscopy. RF magnetometers based on…

Nuclear magnetic resonance imaging (MRI) at the atomic scale offers exciting prospects for determining the structure and function of individual molecules and proteins. Quantum defects in diamond have recently emerged as a promising platform…

Quantum Physics · Physics 2022-04-06 K. S. Cujia , K. Herb , J. Zopes , J. M. Abendroth , C. L. Degen

Detecting and controlling nuclear spin nano-ensembles is crucial for the further development of nuclear magnetic resonance (NMR) spectroscopy and for the emerging solid state quantum technology. Here we present the fabrication of a…

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful and widely used tools for molecular structure elucidation in organic chemistry. However, the interpretation of NMR spectra to determine unknown molecular structures…

Chemical Physics · Physics 2025-09-03 Yongqi Jin , Jun-Jie Wang , Fanjie Xu , Xiaohong Ji , Zhifeng Gao , Linfeng Zhang , Guolin Ke , Rong Zhu , Weinan E