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Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local…

Quantitative Methods · Quantitative Biology 2026-03-17 Sazan Mahbub , Souvik Kundu , Eric P. Xing

Non-Volatile Memories (NVMs) have attracted the attentions of academia and industry, which is expected to become the next-generation memory. However, due to the nonvolatile property, NVMs become vulnerable to attacks and require security…

Cryptography and Security · Computer Science 2019-12-11 Jianming Huang , Yu Hua

Most data intensive applications often access only a few fields of the objects they are operating on. Since NVM provides fast, byte-addressable access to durable memory, it is possible to access various fields of an object stored in NVM…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-07-18 Johnu George , Ramdoot Pydipaty , Xinyuan Huang , Amit Saha , Debo Dutta , Gary Wang , Uma Gangumalla

Memristive in-memory sorting has been proposed recently to improve hardware sorting efficiency. Using iterative in-memory min computations, data movements between memory and external processing units can be eliminated for improved latency…

Hardware Architecture · Computer Science 2022-02-22 Lianfeng Yu , Zhaokun Jing , Yuchao Yang , Yaoyu Tao

Recent developments in large language models (LLMs) have introduced new requirements for efficient and robust training. As LLM clusters scale, node failures, lengthy recoveries, and bulky checkpoints erode efficiency. Infrequent…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-04 Bohan Zhao , Yuanhong Wang , Chenglin Liu , Jiagi Pan , Guang Yang , Ruitao Liu , Tingrui Zhang , Kai Luo , Wei Xu

We present a fully lock-free variant of the recent Montage system for persistent data structures. Our variant, nbMontage, adds persistence to almost any nonblocking concurrent structure without introducing significant overhead or blocking…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-11-12 Wentao Cai , Haosen Wen , Vladimir Maksimovski , Mingzhe Du , Rafaello Sanna , Shreif Abdallah , Michael L. Scott

Model checkpoints are critical Deep Learning (DL) artifacts that enable fault tolerance for training and downstream applications, such as inference. However, writing checkpoints to persistent storage, and other I/O aspects of DL training,…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-21 Guanhua Wang , Olatunji Ruwase , Bing Xie , Yuxiong He

The design of the buffer manager in database management systems (DBMSs) is influenced by the performance characteristics of volatile memory (DRAM) and non-volatile storage (e.g., SSD). The key design assumptions have been that the data must…

Databases · Computer Science 2019-01-31 Joy Arulraj , Andy Pavlo , Krishna Teja Malladi

The next-generation non-volatile memory (NVM) is striding into computer systems as a new tier as it incorporates both DRAM's byte-addressability and disk's persistency. Researchers and practitioners have considered building persistent…

Data Structures and Algorithms · Computer Science 2021-06-02 Chongnan Ye , Chundong Wang

Distributed training of large deep-learning models often leads to failures, so checkpointing is commonly employed for recovery. State-of-the-art studies focus on frequent checkpointing for fast recovery from failures. However, it generates…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-25 Chenxuan Yao , Yuchong Hu , Feifan Liu , Zhengyu Liu , Lin Wang , Mingqi Li , Dan Feng

At the end of Silicon roadmap, keeping the leakage power in tolerable limit and bridging the bandwidth gap between processor and memory have become some of the biggest challenges. Several promising Non-Volatile Memories (NVMs) such as,…

Cryptography and Security · Computer Science 2021-05-14 Mohammad Nasim Imtiaz Khan , Swaroop Ghosh

The advent of non-volatile memory (NVM) technologies like PCM, STT, memristors and Fe-RAM is believed to enhance the system performance by getting rid of the traditional memory hierarchy by reducing the gap between memory and storage. This…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-12-15 Ajay Singh , Marc Shapiro , Gael Thomas

Compute in-memory (CIM) is a promising technique that minimizes data transport, the primary performance bottleneck and energy cost of most data intensive applications. This has found wide-spread adoption in accelerating neural networks for…

Signal Processing · Electrical Eng. & Systems 2021-02-16 Brian Crafton , Samuel Spetalnick , Arijit Raychowdhury

Emerging non-volatile main memory (NVRAM) technologies provide byte-addressability, low idle power, and improved memory-density, and are likely to be a key component in the future memory hierarchy. However, a critical challenge in achieving…

Data Structures and Algorithms · Computer Science 2019-08-22 Guy E. Blleloch , Yan Gu

Non-Volatile Memory (NVM) can deliver higher density and lower cost per bit when compared with DRAM. Its main drawback is that it is slower than DRAM. On the other hand, DRAM has scalability problems due to its cost and energy consumption.…

Performance · Computer Science 2024-12-18 Diego Moura , Vinicius Petrucci , Daniel Mosse

The recent emergence of fast, dense, nonvolatile main memory suggests that certain long-lived data might remain in its natural pointer-rich format across program runs and hardware reboots. Operations on such data must be instrumented with…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-30 Haosen Wen , Wentao Cai , Mingzhe Du , Louis Jenkins , Benjamin Valpey , Michael L. Scott

Iterative methods are commonly used approaches to solve large, sparse linear systems, which are fundamental operations for many modern scientific simulations. When the large-scale iterative methods are running with a large number of ranks…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-30 Dingwen Tao , Sheng Di , Xin Liang , Zizhong Chen , Franck Cappello

Persistent memory provides high-performance data persistence at main memory. Memory writes need to be performed in strict order to satisfy storage consistency requirements and enable correct recovery from system crashes. Unfortunately,…

Hardware Architecture · Computer Science 2017-05-11 Youyou Lu , Jiwu Shu , Long Sun , Onur Mutlu

Persistent Memory (PMEM), also known as Non-Volatile Memory (NVM), can deliver higher density and lower cost per bit when compared with DRAM. Its main drawback is that it is typically slower than DRAM. On the other hand, DRAM has…

Machine Learning · Computer Science 2022-11-07 Diego Moura , Vinicius Petrucci , Daniel Mosse

Deep neural networks (DNNs) have revolutionized the field of artificial intelligence and have achieved unprecedented success in cognitive tasks such as image and speech recognition. Training of large DNNs, however, is computationally…