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Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

The quantum approximate optimisation algorithm (QAOA) is a hybrid quantum-classical algorithm used to approximately solve combinatorial optimisation problems. It involves multiple iterations of a parameterised ansatz comprising a problem…

Quantum Physics · Physics 2024-02-16 V. Vijendran , Aritra Das , Dax Enshan Koh , Syed M. Assad , Ping Koy Lam

The Quantum Approximate Optimization Algorithm (QAOA) requires that circuit parameters are determined that allow one to sample from high-quality solutions to combinatorial optimization problems. Such parameters can be obtained using either…

Quantum Physics · Physics 2023-01-11 David Headley , Frank K. Wilhelm

Many quantum algorithms seek to output a specific bitstring solving the problem of interest--or a few if the solution is degenerate. It is the case for the quantum approximate optimization algorithm (QAOA) in the limit of large circuit…

Quantum Physics · Physics 2022-08-23 Maxime Dupont , Nicolas Didier , Mark J. Hodson , Joel E. Moore , Matthew J. Reagor

Although quantum approximate optimization algorithm (QAOA) has demonstrated its quantum supremacy, its performance on Noisy Intermediate-Scale Quantum (NISQ) devices would be influenced by complicated noises, e.g., quantum colored noises.…

Quantum Physics · Physics 2023-09-04 Bo Yue , Shibei Xue , Yu Pan , Min Jiang

The quantum approximate optimization algorithm (QAOA) is one of the most promising candidates for achieving quantum advantage through quantum-enhanced combinatorial optimization. A near-optimal solution to the combinatorial optimization…

Quantum Physics · Physics 2023-07-12 Alexey Galda , Eesh Gupta , Jose Falla , Xiaoyuan Liu , Danylo Lykov , Yuri Alexeev , Ilya Safro

Quadratic unconstrained binary optimization (QUBO) tasks are very important in chemistry, finance, job scheduling, and so on, which can be represented using graph structures, with the variables as nodes and the interaction between them as…

Quantum Physics · Physics 2024-04-10 Yuhan Huang , Ferris Prima Nugraha , Siyuan Jin , Yichi Zhang , Bei Zeng , Qiming Shao

The quantum approximate optimisation ansatz (QAOA) is one of the flagship algorithms used to tackle combinatorial optimisation on graphs problems using a quantum computer, and is considered a strong candidate for early fault-tolerant…

Quantum Physics · Physics 2025-06-24 Yann Beaujeault-Taudière

The quantum approximate optimization algorithm (QAOA) has become a cornerstone of contemporary quantum applications development. In QAOA, a quantum circuit is trained -- by repeatedly adjusting circuit parameters -- to solve a problem.…

Quantum Physics · Physics 2021-08-17 V. Akshay , D. Rabinovich , E. Campos , J. Biamonte

Establishing quantum advantage for variational quantum algorithms is an important direction in quantum computing. In this work, we apply the Quantum Approximate Optimisation Algorithm (QAOA) -- a popular variational quantum algorithm for…

Quantum Physics · Physics 2024-01-08 Andrew El-Kadi , Roberto Bondesan

The Quantum Approximate Optimization Algorithm (QAOA) is a promising algorithm for solving combinatorial optimization problems (COPs), with performance governed by variational parameters $\{\gamma_i, \beta_i\}_{i=0}^{p-1}$. While most prior…

Quantum Physics · Physics 2025-08-07 J. A. Montanez-Barrera , Kristel Michielsen

The present tutorial aims to provide a comprehensible and easily accessible introduction into the theory and implementation of the famous Quantum Approximate Optimization Algorithm (QAOA). We lay our focus on practical aspects and…

Quantum Physics · Physics 2023-01-24 Andreas Sturm

Quantum optimization algorithms (QOAs) have the potential to fundamentally transform the application of optimization methods in decision making. For certain classes of optimization problems, it is widely believed that QOA enables…

Quantum Physics · Physics 2024-01-15 Florian Klug

Quantum Amplitude Amplification (QAA), the generalization of Grover's algorithm, is capable of yielding optimal solutions to combinatorial optimization problems with high probabilities. In this work we extend the conventional 2-dimensional…

Quantum Physics · Physics 2026-01-16 Daniel Koch , Brian Pardo , Kip Nieman

The quantum approximate optimization algorithm (QAOA) is a method of approximately solving combinatorial optimization problems. While QAOA is developed to solve a broad class of combinatorial optimization problems, it is not clear which…

Quantum Physics · Physics 2020-08-13 James Ostrowski , Rebekah Herrman , Travis S. Humble , George Siopsis

We introduce a relax-and-round approach embedding the quantum approximate optimization algorithm (QAOA) with $p\geq 1$ layers. We show for many problems, including Sherrington-Kirkpatrick spin glasses, that at $p=1$, it is as accurate as…

Quantum Physics · Physics 2024-01-25 Maxime Dupont , Bhuvanesh Sundar

Many combinatorial optimization problems admit a maximin fairness variant, where the aim is to find a distribution over possible solutions which maximizes an expected worst-case outcome. However, the support for an optimal distribution may…

Quantum Physics · Physics 2026-04-17 Bao Bach , Cameron Ibrahim , Reuben Tate , Jad Salem , Stephan Eidenbenz , Ilya Safro

The quantum approximate optimization algorithm (QAOA) holds promise for combinatorial optimization but is constrained by limited qubits. While divide-and-conquer frameworks like QAOA$^{2}$ address scalability by partitioning graphs into…

Quantum Physics · Physics 2026-05-14 Zubin Zheng , Jiahao Wu , Shengcai Liu

In recent years, quantum computing has emerged as a transformative force in the field of combinatorial optimization, offering novel approaches to tackling complex problems that have long challenged classical computational methods. Among…

Optimization problems in disciplines such as machine learning are commonly solved with iterative methods. Gradient descent algorithms find local minima by moving along the direction of steepest descent while Newton's method takes into…

Quantum Physics · Physics 2018-08-20 Patrick Rebentrost , Maria Schuld , Leonard Wossnig , Francesco Petruccione , Seth Lloyd