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Structure-based drug design (SBDD) is crucial for developing specific and effective therapeutics against protein targets but remains challenging due to complex protein-ligand interactions and vast chemical space. Although language models…

Biomolecules · Quantitative Biology 2024-08-20 Cong Fu , Xiner Li , Blake Olson , Heng Ji , Shuiwang Ji

Drug discovery represents a time-consuming and financially intensive process, and virtual screening can accelerate it. Scoring functions, as one of the tools guiding virtual screening, have their precision closely tied to screening…

Machine Learning · Computer Science 2026-01-13 Haotian Gao , Xiangying Zhang , Jingyuan Li , Xinchong Chen , Haojie Wang , Yifei Qi , Renxiao Wang

Verifying an identity claim by fingerprint recognition is a commonplace experience for millions of people in their daily life, e.g. for unlocking a tablet computer or smartphone. The first processing step after fingerprint image acquisition…

Computer Vision and Pattern Recognition · Computer Science 2016-05-16 Duy Hoang Thai , Carsten Gottschlich

We present a novel end-to-end partially supervised deep learning approach for video anomaly detection and localization using only normal samples. The insight that motivates this study is that the normal samples can be associated with at…

Computer Vision and Pattern Recognition · Computer Science 2018-05-30 Yaxiang Fan , Gongjian Wen , Deren Li , Shaohua Qiu , Martin D. Levine

This letter proposes a method of global localization on a map with semantic object landmarks. One of the most promising approaches for localization on object maps is to use semantic graph matching using landmark descriptors calculated from…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Shigemichi Matsuzaki , Kazuhito Tanaka , Kazuhiro Shintani

We push the boundaries of electronic structure-based \textit{ab-initio} molecular dynamics (AIMD) beyond 100 million atoms. This scale is otherwise barely reachable with classical force-field methods or novel neural network and machine…

Virtual Screening (VS) of vast compound libraries guided by Artificial Intelligence (AI) models is a highly productive approach to early drug discovery. Data splitting is crucial for better benchmarking of such AI models. Traditional random…

Quantitative Methods · Quantitative Biology 2024-07-02 Qianrong Guo , Saiveth Hernandez-Hernandez , Pedro J Ballester

Superpixel segmentation algorithms are to partition an image into perceptually coherence atomic regions by assigning every pixel a superpixel label. Those algorithms have been wildly used as a preprocessing step in computer vision works, as…

Computer Vision and Pattern Recognition · Computer Science 2017-02-22 Zhihua Ban , Jianguo Liu , Li Cao

In the field of Simultaneous Localization and Mapping (SLAM), researchers have always pursued better performance in terms of accuracy and time cost. Traditional algorithms typically rely on fundamental geometric elements in images to…

Robotics · Computer Science 2024-03-05 Zhang Zhihe

Molecular docking is an important tool for structure-based drug design, accelerating the efficiency of drug development. Complex and dynamic binding processes between proteins and small molecules require searching and sampling over a wide…

Chemical Physics · Physics 2024-02-23 Runqiu Shu , Bowen Liu , Zhaoping Xiong , Xiaopeng Cui , Yunting Li , Wei Cui , Man-Hong Yung , Nan Qiao

In the expanding field of generative artificial intelligence, integrating robust watermarking technologies is essential to protect intellectual property and maintain content authenticity. Traditionally, watermarking techniques have been…

Machine Learning · Computer Science 2024-10-15 Renyi Yang

Computational validation is vital for all large-scale quantum computers. One needs computers that are both fast and accurate. Here we apply precise, scalable, high order statistical tests to data from large Gaussian boson sampling (GBS)…

Quantum Physics · Physics 2023-08-02 Alexander S. Dellios , Bogdan Opanchuk , Margaret D. Reid , Peter D. Drummond

Geometric Machine Learning (GML) has shown that respecting non-Euclidean geometry in data spaces can significantly improve performance over naive Euclidean assumptions. In parallel, Quantum Machine Learning (QML) has emerged as a promising…

Recently, medical vision-language pre-training (VLP) has reached substantial progress to learn global visual representation from medical images and their paired radiology reports. However, medical imaging tasks in real world usually require…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Che Liu , Cheng Ouyang , Sibo Cheng , Anand Shah , Wenjia Bai , Rossella Arcucci

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Partial tomography, which focuses on reconstructing reduced density matrices (RDMs), has emerged as a promising approach for characterizing complex quantum systems, particularly when full state tomography is impractical. Recently,…

Quantum Physics · Physics 2024-10-18 Chao Wei , Tao Xin

Differentiable particle-based simulation can produce physically plausible motion, but target-driven volumetric shape morphing remains underconstrained: physics-only mass matching captures coarse global structure yet struggles with fine…

Graphics · Computer Science 2026-04-22 Chang-Yong Song , David Hyde

Pre-trained Language Models have emerged as promising tools for predicting molecular properties, yet their development is in its early stages, necessitating further research to enhance their efficacy and address challenges such as…

Machine Learning · Computer Science 2023-10-24 Eduardo Soares , Akihiro Kishimoto , Emilio Vital Brazil , Seiji Takeda , Hiroshi Kajino , Renato Cerqueira

3D Gaussian Splatting (3DGS) has shown its ability in rapid rendering and high-fidelity mapping. In this paper, we introduce LVI-GS, a tightly-coupled LiDAR-Visual-Inertial mapping framework with 3DGS, which leverages the complementary…

Robotics · Computer Science 2024-11-06 Huibin Zhao , Weipeng Guan , Peng Lu

Quantum computing can empower machine learning models by enabling kernel machines to leverage quantum kernels for representing similarity measures between data. Quantum kernels are able to capture relationships in the data that are not…

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